CAS: 10111-08-7; 1H-Imidazole-2-Carbaldehyde

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16042-25-4 33543-78-1 17334-09-7

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2-(1,3-Dibenzoylimidazolidin-2-yl)Imidazole Hydrochloride置于盐酸,水体系中,化学反应生成2-咪唑甲醛
参考文献:Schiff's Base Imidazole Derivatives Synthesis And Evaluation For Their Anti-Inflammatory Activity
标题:Schiff's Base Imidazole Derivatives Synthesis And Evaluation For Their Anti-Inflammatory Activity
摘要:This Study Is Focused On The Synthesis And Exploration Of Schiff's Base Imidazole Derivatives With The Aim Of Assessing Their Anti-Inflammatory Activity. A Series Of Compounds Were Synthesized And Characterized Using Spectroscopic Techniques. In-Silico Docking Analysis Was Employed To Identify Potential Active Ingredients. The Anti-Inflammatory Properties Of These Derivatives Were Then Investigated Using Paw Edema Model Induced By Carrageenan Followed By Assessment Of Tnf-α And Il-1β As Inflammatory Cytokines. Results Showed That Specific Schiff's Base Imidazole Derivatives,Notably C1In,C2In,C4In,C5In,And C11In,Demonstrate Significant Effectiveness In Alleviating Paw Edema And Reducing The Level Of Il-1β And Tnf-α. The Findings Emphasize The Potential Of These Developed Derivatives As Viable Options For Anti-Inflammatory Intervention. The Observed Reduction In Paw Edema And Cytokine Levels Signifies A Promising Anti-Inflammatory Profile,Positioning These Compounds As Candidates For Further Exploration And Development. The Study Contributes Valuable Insights Into The Anti-Inflammatory Properties Of Imidazole Derivatives,Suggesting Their Potential Therapeutic Applications In Inflammatory Conditions. Future Research Should Delve Deeper Into Mechanistic Aspects And Conduct Additional Preclinical Studies To Validate The Translational Potential Of These Derivatives In Anti-Inflammatory Pharmacotherapy. This Research Opens Avenues For The Development Of Novel Anti-Inflammatory Agents With Potential Clinical Relevance.
Doi:10.13005/ojc/400119

专利信息

专利号:US-11891351-B2
优先权日:2020-03-20
标 题 :Synthesis of capsaicin derivatives
发明人：LAGER ERIK
权利人:AXICHEM AS
摘要:The present invention relates to the synthesis of capsaicin derivatives, specifically to the synthesis of 6-heptyne derivatives of capsaicin.

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:US-2024116890-A1
优先权日:2022-09-28
标 题 :Large scale synthesis of cannabinol
发明人：COLLINS ARIANNA C; CRUCES IVAN; RAY KYLE; CRUCES WESTLEY
权利人:COLORADO CHROMATOGRAPY LLC
摘要:Methods for producing cannabinol, cannabivarin, or derivatives thereof are disclosed. The methods disclosed herein can be employed for large scale synthesis or semi-synthesis of the compounds, including multi-kilogram quantities of the compounds.

专利号:US-11512303-B2
优先权日:2017-05-27
标 题 :Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
发明人：CHEN HAIBIN; BONG YONG KOY; XU QING; ZHOU AMENG; SHEN TIANRAN; YANG JIADONG; YANG ZHUHONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

专利号:US-2008125587-A1
优先权日:2006-05-25
标 题 :Synthesis of triazole compounds that modulate HSP90 activity
发明人：CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

专利号:WO-2017089470-A1
优先权日:2015-11-27
标 题:Process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases
发明人：HOFMANN DAGMAR; HOFMANN JOSEFA; HEINRICH MARKUS
权利人:Friedrich-Alexander-Universität Erlangen-Nürnberg
摘要:The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.