CAS: 911417-87-3; 2-(3-(4-((1H-Indazol-5-yl)Amino)Quinazolin-2-yl)Phenoxy)-N-Isopropylacetamide

上下游产品

2-(3-(4-((1H-吲唑-5-基)氨基)喹唑啉-2-基)苯氧基)乙酸 2-(3-(4-(1H-Indazol-5-Ylamino)Quinazolin-2-yl)Phenoxy)Acetic Acid 911417-62-4
Tert-Butyl 5-(2-(3-(2-Tert-Butoxy-2-Oxoethoxy)Phenyl)Quinazolin-4-Ylamino)-1H-Indazole-1-Carboxylate 911417-61-3
5-[[2-(3-羟基苯基)-4-喹唑啉]氨基]-1H-吲唑-1-羧酸1,1-二甲基乙酯 Tert-Butyl 5-(2-(3-Hydroxyphenyl)-Quinazolin-4-Ylamino)-1H-Indazole-1-Carboxylate 911417-26-0

2-溴-N-异丙基乙酰胺置于氯化亚砜,草酰氯,Potassium Carbonate,N,N-二异丙基乙胺,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,乙醇,二氯甲烷,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 8.17H,反应生成 2-[3-[4-[(1H-吲唑-5-基)氨基]喹唑啉-2-基]苯氧基]-N-异丙基乙酰胺
参考文献:Slx-2119的合成方法
标题:Slx-2119的合成方法
摘要:本发明属于药物合成领域,具体公开了一种slx‑2119的合成方法,首先以异丙胺和溴乙酰溴为起始原料制得2‑溴‑n‑异丙基乙酰胺ⅰ,然后再依次与3‑羟基苯甲酸甲酯发生亲核取代反应,酯水解反应,与2‑氨基苯甲胺酰发生胺化反应,环合反应和氯化反应,最后与5‑氨基吲唑发生亲核取代反应,制得slx‑2119.本发明避免了价格昂贵的二羟基苯基硼酸酯,Pd(Dppf)Cl2和2,4二氢喹唑啉等试剂的使用,降低了成本,同时也避免了重金属钯的使用,无重金属污染,环境友好且原药料无重金属残留,反应路线短,产率高,成本低,利于工业化生产.

专利信息

专利号:US-12358903-B2
优先权日:2016-06-13
标题 :FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; FARAND JULIE; GEGE CHRISTIAN; KROPF JEFFREY E; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-11739065-B2
优先权日:2016-06-13
标题 :FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; GEGE CHRISTIAN; KROPF JEFFREY E; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:CN-116874433-A
优先权日:2023-06-16
标 题:A kind of pyrimidine compound and its synthesis method and application