CAS: 823-39-2; 3,4-Dimethylpyridin-2-Amine

该化合物是有机化合物,其特征为:环,是含有一个氮原子的六人芳香热循环,由六人组成;3和4个位置上的两个甲基组和一个氨基组,位于环的2个位置;黄色液体或固态无色,视温度和纯度而定;氨基基组的存在使它成为基本化合物,能够用酸盐形成盐类;在水和酒精等极地溶剂中溶解,但非极溶剂溶解较少.2-Amino-34-二甲基丙烯,在各种化学合成中使用,可以作为生产药物和农用化学物的建筑块;其再活性受氨基和甲基组的电饱和性影响,可参与电动机替代反应;安全数据表明,应谨慎处理,因为它可能导致皮肤和眼睛受到刺激.

结构式图片

相似化合物

57963-11-8 1603-40-3 41995-30-6

上下游产品

CAS号1233519-99-7 bis(1,1-dimethy... | CAS号583-58-4 3,4-二甲基吡啶 | CAS号121-69-7 N,N-二甲基苯胺 | CAS号1796-86-7 Pyridine,3,4-di... | CAS号179555-37-4 2-乙酰氨基-4,5-二甲基吡啶 | CAS号183736-47-2 7-(Butyryloxy)-... | CAS号583-58-4 3,4-二甲基吡啶 | CAS号65169-34-8 2-羟基-3,4-二甲基吡啶

合成工艺路线路线简述

  • 583-58-4 = 823-39-2 + 57963-11-8
    反应条件:1.1 Reagents: Sodium Amide Solvents: Toluene; 24 H,180 °C1.2 Reagents: Water; Rt
    标题:Synthesis Of Two Potential Heterocyclic Amine Food Mutagens
    作者:Tanga,Mary J.; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:2008 卷标:45(3) 页码:661-665]

    613-93-4 = 823-39-2 + 57963-11-8
    反应条件:1.1 Reagents: Thionyl Chloride; 2 H,Reflux2.1 Solvents: Trichloroethylene; 12 H,Reflux2.2 Reagents: Sodium Hydroxide Solvents: Water; 1 H,Reflux3.1 Reagents: Sodium Amide Solvents: Toluene; 24 H,180 °C3.2 Reagents: Water; Rt
    标题:Synthesis Of Two Potential Heterocyclic Amine Food Mutagens
    作者:Tanga,Mary J.; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:2008 卷标:45(3) 页码:661-665]

    57261-60-6 = 823-39-2
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Acetone,Water; 15 Min,Rt; 2 - 3 H,30 - 70 °C1.2 Reagents: Sodium Hydroxide,Bromine Solvents: Water; 0 °C; 0 °C -> 75 °C; 0.5 - 1.5 H,75 °C
    标题:Synthesis Of 2-Pyridinamines And Their Alkyl Derivatives From 2-Cyanopyridines
    作者:Dai,Liyan; Et Al
    参考文献:Huagong Xuebao (Chinese Edition) 日期:2007 卷标:58(3) 页码:670-672]

    583-58-4 = 823-39-2
    反应条件:1.1 Reagents: Sodium Amide
    标题:Metal-Chelating 1,3-Bis(2-Pyridylimino)Isoindolines
    作者:Siegl,Walter O.
    参考文献:Journal Of Heterocyclic Chemistry 日期:1981 卷标:18(8) 页码:1613-18]

    21737-87-1 + 1796-86-7 = 823-39-2 + 57963-11-8
    反应条件:1.1 Solvents: Trichloroethylene; 12 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water; 1 H,Reflux2.1 Reagents: Sodium Amide Solvents: Toluene; 24 H,180 °C2.2 Reagents: Water; Rt
    标题:Synthesis Of Two Potential Heterocyclic Amine Food Mutagens
    作者:Tanga,Mary J.; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:2008 卷标:45(3) 页码:661-665
📜3,4-二甲基-吡啶氮氧化物置于盐酸体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 2-氨基-3,4-二甲基吡啶
参考文献:Substituted 2-Aminopyridines As Inhibitors Of Nitric Oxide Synthases
标题:Substituted 2-Aminopyridines As Inhibitors Of Nitric Oxide Synthases
摘要:A Series Of Substituted 2-Aminopyridines Was Prepared And Evaluated As Inhibitors Of Human Nitric Oxide Synthases (Nos). 4,6-Disubstitution Enhanced Both Potency And Specificity For The Inducible Nos With The Most Potent Compound Having An Ic50 Of 28 Nm. (C) 2000 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(00)00389-9

海关参考信息

专利信息


专利号:US-6022984-A
优先权日:1998-07-27
标 题:Efficient synthesis of furan sulfonamide compounds useful in the synthesis of new IL-1 inhibitors
发明人:URBAN FRANK J; JASYS VYTAUTAS J
权利人:PFIZER
摘要:An efficent synthesis of furan sulfonamide compounds of formula ##STR1## comprising reacting a compound of formula 11 with a Grignard reagent in a reaction inert solvent, wherein R' is (C 1 -C 6 )alkyl. The compound of formula II is prepared by reacting a compound of formula III with a compound of formula IV wherein R' is (C 1 -C 6 )alkyl with a chorinating reagent and an acid scaverger in an inert solvent. The invention also includes a novel compound of the formula ##STR2## wherein R' is (C 1 -C 6 )alkyl and Q is halo, hydroxy or amino.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人:HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:WO-2023099297-A1
优先权日:2021-12-02
标 题:Synthesis of hmo butyrate
发明人:BONRATH WERNER; DE-BOER CASPER; GEBHARD RONALD; GOETZINGER ALISSA; WUESTENBERG BETTINA
权利人:DSM IP ASSETS BV
摘要:The present invention relates to new specific butyrate compounds to a new and improved synthesis of specific butyrates as well their use. Butyrate compounds are very useful compounds.

专利号:US-7122693-B2
优先权日:1988-04-11
标题 :Acetaldehyde acetal compounds, their synthesis, and uses thereof
发明人:BELLEAU EXECUTRIX OF ESTATE PI; DIXIT DILIP M; NGUYEN-BA NGHE
权利人:SHIRE BIOCHEM INC
摘要:The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.

专利号:WO-2025122636-A1
优先权日:2023-12-04
标题:Method for the synthesis of acrylate derivatives
发明人:CAICEDO-CARVAJAL CARLOS; KATZ JORDAN; CHOI SEAN
权利人:ORTHOBOND CORP
摘要:The disclosure relates to the synthesis of quaternary salts of various acrylates in high yield and high purity.

专利号:US-5144034-A
优先权日:1990-04-06
标题 :Process for the synthesis of cyclopentene derivatives of purines
发明人:JOHNSON M ROSS; PEEL MICHAEL R; STERNBACH DANIEL D
权利人:GLAXO INC
摘要:This invention relates to a new process for preparing certain optically active cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1'R-cis isomer of carbovir, (1'R-cis)-2-amino-1,9-dihydro-9[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one, an antiviral agent.

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✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Synthesis Of Novel Intermediate(S) For Preparing Rivastigmine
摘要:The Present Invention Relates To Novel Intermediate(S), Which Are Useful For The Preparation Of Rivastigmine Compound Of Formula (I) And Its Pharmaceutically Acceptable Salts. The Present Invention Further Relates To The Processes For The Preparation Of Such Novel Intermediate(S) And Preparation Of Rivastigmine Using Such Novel Intermediate(S).

合成参考文献


参考文献:10.1016/s0939-6411(03)00151-6
摘要:Polnok A, Borchard G, Verhoef JC, Sarisuta N, Junginger HE. Influence of methylation process on the degree of quaternization of N-trimethyl chitosan chloride. European Journal of Pharmaceutics and Biopharmaceutics. 2004 Jan;57(1):77–83. doi: 10.1016/s0939-6411(03)00151-6.
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