CAS: 7651-82-3; Isoquinolin-6-Ol

相似化合物

7651-83-4 2439-04-5 3482-14-2

上下游产品

6-methoxyisoquinoline 6-bromo-isoquinoline methanol6-isoquinolinamine 6,6-Diphenyl-6H-5-oxa-2-aza-phenanthrene 5-chloro-6-hydroxyisoquinoline (S)-5-isoquinolin-6-yloxy-4-N-B°C-1-N'-Z-pentane-1,4-diamine

6-甲氧基异喹啉置于trimethylammonium Heptachlorodialuminate体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 6-羟基异喹啉
参考文献:氯铝酸盐离子液体试剂裂解芳香族甲基醚
标题:氯铝酸盐离子液体试剂裂解芳香族甲基醚
摘要:我们意外地发现氯铝酸盐离子液体可以在令人惊讶的温和条件下裂解芳香族甲基醚.三种离子液体,即.[tmah][al2Cl7],[bmim][al2Cl7],[emim][al2Cl6I] 和氯化铝在 4-甲氧基官能团的 4,5-二甲氧基茚满酮的选择性去甲基化中进行了比较.与氯化铝 (70:30) 相比,离子液体表现出非常高的选择性 (96:4).此外,当使用离子液体时,反应时间大大缩短.有趣的是,这三种离子液体在 4,5-二甲氧基茚满酮的去甲基化反应中表现出相同的反应性.考虑到 [tmah][al2Cl7] 前体的较低成本和大量可用性,我们得出结论,从工业角度来看,这是最具吸引力的离子液体.为了使 [tmah][al2Cl7] 的大规模应用可行,我们开发了一种安全的,可升级的制备方法.此外,研究了离子液体试剂[tmah][al2Cl7]对醚裂解的范围,发现芳香甲基-,烯丙基-和苄基-醚裂解适用于多种杂环化合物.(©
DOI:10.1002/ejoc.200210666

专利信息

专利号:US-2006287529-A1
优先权日:2003-02-20
标 题:Solid phase synthesis of antitumoral compounds
发明人：ALVAREZ MERCEDES; ALBERICIO FERNANDO; CIRONI PABLO; CUE VAS CARMEN; FRANCESCH ANDREAS; MARFIL MARTA
权利人:ALVAREZ MERCEDES; ALBERICIO FERNANDO; CIRONI PABLO; CUE VAS CARMEN; FRANCESCH ANDREAS; MARFIL MARTA
摘要:Lamellarins are prepared using a solid phase synthesis. In a first aspect, the process includes a step as follows: Formula (I) where R 1 to R 15 are as defined, and X is halogen, provided that one of R 2 , R 3 or R 4 is immobilised to a resin. In a second aspect, the process includes a step as follows: Formula (II) where R 1 ′ to R 5 ′, R 11 ′ and R 13 ′ are as defined, X 1 and X 2 are halogen, M is a metal function and PG is an amino protecting group, provided that one of that R 2 ′, R 3 ′ or R 4 ′ is immobilised to a resin.

专利号:EP-1613635-A2
优先权日:2003-02-20
标题 :Solid phase synthesis of antitumoral compounds

专利号:US-6482921-B1
优先权日:1999-01-28
标题:Uridyl peptide antibiotic (UPA) derivatives, their synthesis and use
发明人：BOOJAMRA CONSTANTINE G; LEMOINE REMY C; HECKER SCOTT; LEE VING J; LEGER ROGER
权利人:ESSENTIAL THERAPEUTICS INC
摘要:The present invention relates to dihydro derivatives of the uridyl peptide antibiotics mureidomycin, pacidimycin and napsamycin which have antibiotic activity against a number of bacterial strains including strains resistant to current therapeutic antibiotics.

专利号:AU-2004212762-A1
优先权日:2003-02-20
标 题:Solid phase synthesis of antitumoral compounds

专利号:CA-2515313-A1
优先权日:2003-02-20
标 题 :Solid phase synthesis of antitumoral compounds

专利号:EP-0772595-B1
优先权日:1994-07-22
标 题:Monomeric and dimeric naphthylisoquinoline alkaloids and synthesis methods thereof
发明人：BRINGMANN GERHARD; HARMSEN SVEN; GOTZ ROLAND; BOYD MICHAEL R
权利人:US HEALTH
摘要:The present invention provides methods of preparing monomeric naphthylisoquinoline alkaloids, including the antiparasitic korupensamines and related compounds, as well as non-korupensamines and other monomeric naphthylisoquinoline alkaloids. The present invention also provides methods of preparing dimeric naphthylisoquinoline alkaloids by coupling together two monomeric naphthylisoquinoline alkaloids, each of which may be the same or different, and one, both, or neither of which may possess a C-8' to C-5 naphthalene/isoquinoline linkage, to form homodimers or heterodimers, including the antiviral michellamines. The present invention further provides new, medically useful monomeric naphthylisoquinoline compounds and homodimeric and heterodimeric naphthylisoquinoline compounds and derivatives thereof.