CAS: 6317-37-9; 5-Nitrothiophene-2-Carboxylic Acid

该化合物是有机化合物,其特点是存在硫苯环,这是一种五人组成的芳香循环环,含有硫磺,该化合物的特点是硝基化合物(-NO2)和一个附于硫苯并环的箱状酸组(-COOH),具体地说,在5和2个位置上;硝基化合物组有助于化合物的电子提取特性,这种特性可影响该化合物在各种化学环境中的再活动与相互作用;氨基酸组具有酸性特性,使该化合物能够参与酸基反应;该物质通常用于有机合成,并可作为生产药品,农用化学品或其他功能材料的中间体;其溶剂和稳定性可因溶剂和条件而异,因此在实际应用中必须考虑到这些因素;

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

5-nitro-2-thiophenecarboxaldehyde 5-nitro-2-thienyl cyanide 2-acetyl-5-nitrothiophene 2-thiophenylcarboxylic acid 5-nitro-2-thiophenecarboxylic acid ethyl ester 5-aminopentanoic acid methyl 5-nitrothiophene-2-carboxylate 5-acetylaminothiophene-2-carboxylic acid

合成工艺路线路线简述

  • 合成目标产物 5-Nitrothiophene-2-Carboxylic Acid 主要起始原料 5-Nitrothiophene-2-Carboxaldehyde
  • (文献来源)合成步骤主要原料 5-Nitrothiophene-2-Carboxaldehyde
2-噻吩甲酸 反应生成 5-硝基噻吩-2-甲酸
参考文献:Heterocyclic Amides With Anti-Tuberculosis Activity
标题:Heterocyclic Amides With Anti-Tuberculosis Activity
摘要:具有一般结构的化合物:其中a从氧,硫和nr15组成的群体中选择,R15从h,烷基,芳基,取代烷基和取代芳基组成的群体中选择;b,D和e分别独立地从ch,氮,硫和氧组成的群体中选择;r1从硝基,卤素,烷基酯,芳基硫醚,芳基亚砜,芳基砜基和磺酸中选择;t为1到3的整数;x为取代酰胺,并且使用这些新化合物治疗由微生物引起的感染的方法,包括结核分枝杆菌.

海关参考信息

专利信息


专利号:US-2004254162-A1
优先权日:2001-07-16
标 题 :Oxazolidinone derivatives as antimicrobials
发明人:MEHTA ANITA; ARORA SUDERSHAN R; DAS BISJAWIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK
摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharma-ceutical compositions containing the compounds of the present invention as anti-microbials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:US-6956040-B2
优先权日:2001-07-16
标题:Oxazolidinone piperazinyl derivatives as potential antimicrobials
发明人:MEHTA ANITA; ARORA SUDERSHAN K; DAS BISWAJIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK
权利人:RANBAXY LAB LTD
摘要:The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula I n n nwith the variables as defined within, and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:US-4093622-A
优先权日:1975-05-19
标题 :Pyridine esters of cyclopropane-carboxylic acid
发明人:HENRICK CLIVE A; STAAL GERARDUS B
权利人:ZOECON CORP
摘要:Heterocyclic organic esters and thioesters characterized by the presence of one or two cyclopropane moieties, synthesis thereof, and compositions thereof for the control of mites and ticks.

专利号:US-6734307-B2
优先权日:2000-07-17
标 题:Oxazolidinone derivatives as antimicrobials
发明人:MEHTA ANITA; SUDERSHAN ARORA K; DAS BISWAJIT; RAY ABHIJIT; RUDRA SONALI; RATTAN ASHOK
权利人:RANBAXY LAB LTD
摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:WO-2004069816-A1
优先权日:2003-02-07
标 题:Oxazolidinone derivatives as antimicrobials
发明人:MEHTA ANITA; RUDRA SONALI; RAO AJJARAPU VENKATA SUBRAHMAN; YADAV AJAY SINGH; RATTAN ASHOK
权利人:RANBAXY LAB LTD; MEHTA ANITA; RUDRA SONALI; RAO AJJARAPU VENKATA SUBRAHMAN; YADAV AJAY SINGH; RATTAN ASHOK
摘要:The present invention relates to certain substituted phenyl oxazolidinones of the formula h wherein T is a ring and to the processes for the synthesis of the same. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bactericides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:CN-102127063-A
优先权日:2011-01-06
标题:New synthesis technology of anti-cancer drug Raltitrexed
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合成参考文献


摘要:E. Imoto and R. Motoyama, Bull. Naniwa Univ. 2A, 127 (1954); CA 49, 9614.
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