CAS: 62391-99-5; 2-Isopropylpentanoic Acid

相似化合物

20225-24-5 74322-93-3 27610-89-5

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CAS号503-74-2 异戊酸 | CAS号107-08-4 1-碘丙烷 | CAS号66730-62-9 monolithium mon... | CAS号75-30-9 2-碘代丙烷 | CAS号109-52-4 正戊酸 | CAS号62391-98-4 diethyl 2-propa... | CAS号2163-48-6 丙基丙二酸二乙酯 | CAS号62391-97-3 [cyano-(3-pheno...

📜异戊酸乙酯置于sodium Hydroxide,Lithium Diisopropyl Amide体系中,用 甲醇,正己烷 作为反应溶剂,化学反应 1.0H,反应生成 丙戊酸杂质b 2,2-二-正丙基乙酸
参考文献:钯催化未激活的c(sp 3)-h键的位点选择性氟化
标题:钯催化未激活的c(sp 3)-h键的位点选择性氟化
摘要:过渡金属催化的直接c-h键氟化是制备有机氟的有吸引力的合成工具.尽管存在许多直接进行sp 3 C-h官能化的方法,但未活化的sp 3碳的位点选择性氟化仍然是一个挑战.据报道,通过钯催化的双齿配体定向的c-h键官能化过程,可以在未活化的sp 3碳上进行直接,高度位点选择性和非对映选择性的氟化.用这种方法,以乙酸钯为催化剂,Selectfluor为氟源,制备了多种在医学和农业化学中重要的基序的β-氟化氨基酸衍生物和脂族酰胺.
DOI:10.1021/acs.Orglett.5B01710

专利信息

专利号:US-6630602-B1
优先权日:1998-04-16
标题 :Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them
发明人：BIALER MEIR; SPIGELSTEIN OFER; YAGEN BORIS
权利人:YISSUM RES DEV CO
摘要:The present invention relates to racemic propylisopropyl acetic acid and propylisopropyl acetamide and their isomers in their racemic and stereospecific forms, for use in treatment of neurological and psychotic disorders, and affective disorders and to treat pain, headaches and migraines. The isomers are of the compound formula I:wherein R1 is a methyl or ethyl group; R2 is H, methyl or an ethyl group; R3 is ethyl or a propyl group; and R4 is a hydroxyl or amide group; and the total number of carbon atoms in said compound is 8, provided that when R1 is a methyl group and R4 is an amide group, R2 and R3 are not ethyl, further provided that when R1 is an ethyl and R4 a hydroxyl group, only stereoisomers of the compound are referred to. The present invention further relates to a method for the stereoselective synthesis of the 2S and 2R stereoisomer of PID and PIA. The present invention also relates to pharmaceutical compositions containing as an active ingredient a racemic mixture or stereoisomers of the compounds of the general formula (I), which are useful for the treatment of neurological and psychotic disorders, and affective disorders and to treat pain, headaches and migraines.

专利号:US-6969732-B2
优先权日:1999-04-12
标 题 :Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them
发明人：BIALER MEIR; SPIGELSTEIN OFER; YAGEN BORIS
权利人:YISSUM RES DEV CO
摘要:The present invention relates to racemic propylisopropyl acetic acid and propylisopropyl acetamide and their isomers in their racemic and stereospecific forms, for use in treatment of neurological and psychotic disorders, and affective disorders and to treat pain, headaches and migraines. The isomers are of the compound formula I n n R 1 is a methyl or ethyl group; R 2 is H, methyl or an ethyl group; R 3 is ethyl or a propyl group; and R 4 is a hydroxyl or amide group,n nand the total number of carbon atoms in said compound is 8, provided that when R1 is a methyl group and R4 is an amide group, R2 and R3 are not ethyl, further provided that when R1 is an ethyl and R4 a hydroxyl group, only stereoisomers of the compound are referred to.n nn The present invention further relates to a method for the stereoselective synthesis of the 2R stereoisomer of PID and PIA. The present invention also relates to pharmaceutical compositions containing as an active ingredient a racemic mixture or stereoisomers of the compounds of the general formula (I), which are useful for the treatment of neurological and psychotic disorders, and affective disorders and to treat pain, headaches and migraines.

专利号:WO-9630393-A1
优先权日:1995-03-27
标 题:A method for the synthesis of mixtures of compounds
发明人：BECKER KATHERINE; DEWITT SHEILA HOBBS
权利人:WARNER LAMBERT CO
摘要:Described is a method of synthesizing a plurality of compounds in a plurality of wells comprising the steps of: (a) providing a plurality of test wells in a plurality of arrays of the wells; (b) reacting in at least a one step reaction a first reagent with a plurality of reagents called building blocks in the test well to obtain a unique product designed to be the same in each array; and (c) continuing to react reagents such that there are multiple reagents resulting in mixtures of multiple different products in each well.

专利号:US-12280059-B2
优先权日:2019-02-21
标题 :Acyl-CoA synthetase 4 (ACSL4) inhibitory compound
发明人：PODESTÃ? ERNESTO J; MALOBERTI PAULA M; ORLANDO ULISES D; CASTILLO ANA F; SOLANO ANGELA R; LORENZANO MENNA PABLO; GOMEZ DANIEL E; SZAJNMAN SERGIO H; PRADA JESSICA G; RODRIGUEZ JUAN B
权利人:CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECN CONICET; UNIV NACIONAL DE QUILMES; UNIV BUENOS AIRES
摘要:A new compound of formula A for the treatment of aggressive and/or resistant tumors expressing acyl-CoA synthetase 4 (ACSL4) and/or depending on steroids action. More particularly, the compound of the present invention inhibits tumor growth in ACSL4-expressing breast and prostate cancers, inhibits steroid synthesis and sensitizes cells towards chemotherapeutic and hormone therapy agents. Pharmaceutical compositions comprising the ACSL4-inhibitory compound of the invention, pharmaceutical combinations thereof with other anticancer agents and use in therapy.