CAS: 611-35-8; 4-Chloroquinoline

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635-27-8 86-98-6 4964-77-6

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CAS号611-36-9 4-羟基喹啉 | CAS号4637-59-6 4-氯喹啉1-氧化物 | CAS号529-37-3 喹啉-4(1H)-酮 | CAS号56-57-5 4-硝基喹啉-N-氧化物 | CAS号875-66-1 4-羟基噌嗪 | CAS号34785-11-0 4-羟基喹啉-3-羧酸 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号5234-26-4 N-(2-乙酰苯基)乙酰胺 | CAS号23432-39-5 4-肼基-6-甲氧基喹啉 | CAS号6279-51-2 4-氨基-6-甲氧基喹啉 | CAS号104771-99-5 N,N'-di(quinoli... | CAS号4979-79-7 4-氯-2-苯基喹啉 | CAS号60814-30-4 1-(喹啉-4-基)乙-1-酮 | CAS号607-31-8 4-甲氧基喹啉 | CAS号4552-43-6 4-氯-2-氰基喹啉 | CAS号149429-24-3 13H-Benz[5,6]in... | CAS号14095-26-2 4-quinolin-4-yl... | CAS号491-35-0 4-甲基喹啉 | CAS号220844-45-1 喹啉-4-氨基甲酸叔丁酯 | CAS号91-22-5 喹啉

4-氯喹啉-N-氧化物置于zinc Trifluoromethanesulfonate体系中,用 乙腈 作为反应溶剂,化学反应 1.08H,以79%的收率获得产物4-氯喹啉
参考文献:An Efficient And General Method For The Deoxygenation Of Organic N-Oxides Using Zn(Otf)2 And Cu(Otf)2
标题:An Efficient And General Method For The Deoxygenation Of Organic N-Oxides Using Zn(Otf)2 And Cu(Otf)2
摘要:本文描述了一种温和且高效的通用方法,利用zn(Otf)2和cu(Otf)2对有机n-氧化物(如偶氮苯,N-芳基亚硝胺和n-杂环n-氧化物)进行脱氧反应,产率优异.
DOI:10.1055/s-2006-926269

专利信息

专利号:US-6472534-B2
优先权日:1999-10-21
标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
发明人：BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K
权利人:AGOURON PHARMA
摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.

专利号:US-6500955-B1
优先权日:2001-02-02
标 题:One pot synthesis of [2,8-Bis (trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, a mefloquine intermediate
发明人：CHAWLA HARMANDER PAL SINGH; JOHAR PERMINDER SINGH; MITTAL ALKA; MEENA RAM AVTAR; NEGI VILLENDRA SINGH
权利人:NAT INST OF PHARMACEUTICAL EDU
摘要:The present invention provides a simple single step process for the preparation of [2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, comprising the step of condensing a halo-quinoline with an alpha-picolyl derivatives in the presence of a solvent, a base and a phase transfer catalyst at −10° C. to +90° C.

专利号:WO-2010144434-A1
优先权日:2009-06-09
标题 :Derivatives of mefloquine and associated methods for making and using
发明人：DOW GEOFFREY S; MILNER ERIN E; WIPF PETER; MO TINGTING
权利人:US OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF U S; DOW GEOFFREY S; MILNER ERIN E; WIPF PETER; MO TINGTING
摘要:The present invention relates to new mefloquine derivatives and therapeutic compositions comprising one or more mefloquine derivatives. Mefloquine derivatives of the invention have a pentafluorosulfanyl moiety substitution at the 8-position. Certain mefloquine derivatives further include a quinoline methanol moiety substitution at the 4-position. The present invention also relates to new intermediate compounds useful in the synthesis of the mefloquine derivatives, which intermediates also have a pentafluorosulfanyl moiety substitution at the 8-position.

专利号:US-3989691-A
优先权日:1973-01-05
标 题 :Preparation of cinchona alkaloid intermediates
发明人：TAYLOR EDWARD C; MARTIN STEPHEN F
权利人:UNIV PRINCETON
摘要:4-[3-(3-vinyl-1-acetyl-4-piperidyl)-1-propenyl]-6-methoxyquinoline, the corresponding epoxide and related compounds, useful in the synthesis of Cinchona alkaloids, are prepared by introducing an ylid group in the 4-position of a suitably substituted quinoline and reacting this ylid with an N-acetyl-4-piperidineacetaldehyde.

专利号:US-2002038033-A1
优先权日:1999-10-21
标题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors

专利号:US-2003023092-A1
优先权日:1999-10-21
标题 :Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors