CAS: 4921-82-8; N-(Phenylcarbamothioyl)Benzamide

该化合物是一种有机化合物,具有独特的结构特征,包括苯并胺碱和联苯氨基替代物所附的二氧甲基组,其典型特征与氨酰胺和硫化合物有关,例如有机溶剂中的潜在溶性,在标准条件下具有中度稳定性;二氧基组的存在可产生特定的反应性,特别是在核阴性替代反应或与电极的相互作用方面;此外,苯氨酸组可能影响化合物的电子特性,可能影响其再活动及与生物系统的互动;这种化合物可能对其潜在的生物活动,包括抗微生物或抗癌特性,具有药物化学化学化学作用,但需要进行详细研究,以充分阐明其化学行为,生物活动以及各个领域的潜在应用,包括药物和材料科学.

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CAS号532-55-8 苯甲酰基异硫氰酸酯 | CAS号98-88-4 苯甲酰氯 | CAS号540-72-7 硫氰酸钠 | CAS号1132-44-1 Acetamide,N-[(p... | CAS号108324-95-4 1-(N-Benzoylthi... | CAS号108306-65-6 3-Benzoylimino-... | CAS号142-04-1 苯胺盐酸盐 | CAS号93-98-1 N-苯甲酰替苯胺 | CAS号55-21-0 苯甲酰胺 | CAS号100-52-7 苯甲醛 | CAS号134-81-6 联苯甲酰 | CAS号103-85-5 N-苯基硫脲 | CAS号532-55-8 苯甲酰基异硫氰酸酯 | CAS号102-08-9 二苯基硫脲 | CAS号1821-33-6 Urea, 1-benzoyl... | CAS号6590-95-0 2,6-二氯苯基异硫氰酸酯

合成工艺路线路线简述

    📜3-Benzoylimino-N-Phenyl-5,6-Dihydroimidazo[2,1-C][1,2,4]Dithiazol-4-Ium-7-Carboximidothioate 以 乙醇,苯 作为反应溶剂,化学反应 1.17H,反应生成 1-苯酰基-3-苯基硫脲
    参考文献:Synthesis And Transformations Of 3-Benzoylimino-5,6-Dihydro-3H-(Imidazo[2,1-C][1,2,4]Dithiazole)
    标题:Synthesis And Transformations Of 3-Benzoylimino-5,6-Dihydro-3H-(Imidazo[2,1-C][1,2,4]Dithiazole)
    摘要:
    DOI:10.1055/s-1986-33422

    海关参考信息

    专利信息


    专利号:US-2016194279-A1
    优先权日:2012-12-09
    标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
    发明人:CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
    权利人:COUNCIL SCIENT IND RES
    摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

    专利号:US-8372971-B2
    优先权日:2004-08-25
    标 题:Heterocyclic compounds and methods of use
    发明人:WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
    权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
    摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    1. Singh, R.K., Cho, K., Padi, S.K., et al. Mechanism of N-Acylthiourea-mediated activation of human histone deacetylase 8 (HDAC8) at molecular and cellular levels. The Journal of Biological Chemisty 290(10), 6607-6619 (2015). 2. Singh, R.K., Mandal, T., Balsubramanian, N., et al. Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate. Bioorg. Med. Chem. Lett. 21(19), 5920-5923 (2011). 3. Wang, L., Bai, X., Zhang, X., et al. Activation of HDAC8 can suppress the proliferation of osteosarcoma cells via TP53 and STAT3/ERK signaling pathways. Ann. Clin. Lab. Sci. 53(6), 920-930 (2023).

    合成参考文献


    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#03316
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