📜3-Benzoylimino-N-Phenyl-5,6-Dihydroimidazo[2,1-C][1,2,4]Dithiazol-4-Ium-7-Carboximidothioate 以 乙醇,苯 作为反应溶剂,化学反应 1.17H,反应生成 1-苯酰基-3-苯基硫脲 参考文献:Synthesis And Transformations Of 3-Benzoylimino-5,6-Dihydro-3H-(Imidazo[2,1-C][1,2,4]Dithiazole) 标题:Synthesis And Transformations Of 3-Benzoylimino-5,6-Dihydro-3H-(Imidazo[2,1-C][1,2,4]Dithiazole) 摘要: DOI:10.1055/s-1986-33422
专利号:US-2016194279-A1 优先权日:2012-12-09 标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas 发明人:CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR 权利人:COUNCIL SCIENT IND RES 摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.
专利号:US-8372971-B2 优先权日:2004-08-25 标 题:Heterocyclic compounds and methods of use 发明人:WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA 权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA 摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
1. Singh, R.K., Cho, K., Padi, S.K., et al. Mechanism of N-Acylthiourea-mediated activation of human histone deacetylase 8 (HDAC8) at molecular and cellular levels. The Journal of Biological Chemisty 290(10), 6607-6619 (2015). 2. Singh, R.K., Mandal, T., Balsubramanian, N., et al. Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate. Bioorg. Med. Chem. Lett. 21(19), 5920-5923 (2011). 3. Wang, L., Bai, X., Zhang, X., et al. Activation of HDAC8 can suppress the proliferation of osteosarcoma cells via TP53 and STAT3/ERK signaling pathways. Ann. Clin. Lab. Sci. 53(6), 920-930 (2023).
合成参考文献
摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#03316