CAS: 488-43-7; (2R,3R,4R,5S)-6-Aminohexane-1,2,3,4,5-Pentaol

上下游产品

CAS号50-99-7 D(+)-无水葡萄糖 | CAS号608-81-1 D-Glucose, oxime | CAS号14199-88-3 1-Deoxy-1-nitro... | CAS号74410-48-3 N-苄基-d-葡萄胺 | CAS号10323-20-3 D-阿拉伯糖 | CAS号3713-25-5 D-glucose pheny... | CAS号4429-04-3 (2R,3S,4R,5R)-2... | CAS号100-01-6 对硝基苯胺 | CAS号3646-57-9 bis(4-nitrophen... | CAS号97-02-9 2,4-二硝基苯胺 | CAS号75-47-8 三碘甲烷 | CAS号102-08-9 二苯基硫脲 | CAS号24808-42-2 Glucitol,1-deox... | CAS号111-26-2 正己胺 | CAS号5735-25-1 Glucitol,1-(ace...

葡萄糖置于ammonium Hydroxide,Ammonium Acetate,Sodium Cyanoborohydride体系中,用 乙醇 作为反应溶剂,以77%的收率获得产物d-萄糖胺
参考文献:Mr1配体糖类似物对粘膜相关不变t(mait)细胞活化的影响.
标题:Mr1配体糖类似物对粘膜相关不变t(mait)细胞活化的影响.
摘要:粘膜相关不变t(mait)细胞是最近鉴定的先天样t淋巴细胞的一个子集,它们似乎在从病毒和细菌感染到自身免疫性疾病和癌症的许多病理中起着重要作用.mait细胞通过mr1在mait T细胞受体(tcr)的抗原呈递细胞上呈递配体而被激活,但是很少有研究探索系统改变配体结构对mr1结合和mait细胞活化的影响.在此,我们报道了关于已知mait细胞激动剂7-羟基-6-甲基-8-D-Ribityllumazine(rl-6-Me-7-Oh)和5中糖基序变化的影响的首次研究. (2-氧代丙基亚氨基)-6-D-核糖基氨基尿嘧啶(5-Op-Ru).mait细胞的四聚体染色显示缺少2' Lumazines的糖主链上的-羟基基团改善了mr1-Mait Tcr结合,这可以使用计算对接研究进行合理化.尽管没有一种二嗪类化合物激活mait细胞,但所有5-Op-Ru类似物均显示出显着的mait细胞激活,其中几种类似物的
DOI:10.1039/c9Ob01436E

专利信息

专利号:US-11891375-B2
优先权日:2021-07-26
标 题 :Method for the synthesis of 2,4-dimethylpyrimidin-5-ol, intermediates, and method for the synthesis of Lemborexant using the intermediates
发明人：AKHATOU ABDESLAM; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.

专利号:US-11639349-B2
优先权日:2020-05-28
标题:Stereoselective synthesis of intermediate for preparation of heterocyclic compound
发明人：CHEN WEN-CHANG; HSU HAN-PEI; CHOU SHAN-YEN; CHUANG SHIH-CHIEH; YEN CHI-FENG
权利人:TAI GEN BIOTECHNOLOGY CO LTD; TAIGEN BIOPHARMACEUTICALS CO BEIJING LTD; TAIGEN BIOTECHNOLOGY CO LTD
摘要:Provided is a stereoselective synthesis of an intermediate for the preparation of the heterocyclic derivative as a Cap-dependent endonuclease inhibitor. The synthesis process has the advantages of simple operation, higher yield and relatively controllable steroselectivity, such that it is suitable for large-scale production.

专利号:US-9815771-B2
优先权日:2014-08-06
标题 :Method for the synthesis of mirabegron and its derivatives
发明人：MARQUILLAS OLONDRIZ FRANCISCO; RIEGO ARBOLEYA ESTELA
权利人:INTERQUIM SA
摘要:The present invention refers to a method for the synthesis of a compound of formula (I), solvates, stereoisomers or salts thereof, a key intermediate in the synthesis of Mirabegron by reduction of an amide in the presence of an amine-boranecomplex, wherein the amine is an aniline.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-7435861-B2
优先权日:2005-04-29
标 题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
发明人：LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID
权利人:CARDAX PHARMACEUTICALS INC
摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

专利号:US-2008221377-A1
优先权日:2006-06-16
标题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
发明人：LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
权利人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.