CAS: 34846-44-1; 3-(Bromomethyl)Thiophene

上下游产品

tetrachloromethane N-Bromosuccinimide 3-Methylthiophene dibenzoyl peroxide N,N-dimethyl-N'-[2]pyridyl-N'-[3]thienylmethyl-ethylenediamineN,N-dimethyl-N'-[2]pyridyl-N'-[3]thienylmethyl-ethylenediamine (thiophen-3-yl)acetonitrile thiophen-3-yl-acetic acid 2-(thiophen-3-ylmethyl)phenol

3-甲基噻吩置于n-溴代丁二酰亚胺(Nbs)体系中,用 四氯化碳 用作溶剂,化学反应 0.67H,以78%的收率获得3-溴甲基噻吩
参考文献:Synthesis Of 4-[ω-(3-Thienyl)Alkyl]Pyridines And 4-[ω-(3-Thienyl)Alkyl]-2,2'-Bipyridines
标题:Synthesis Of 4-[ω-(3-Thienyl)Alkyl]Pyridines And 4-[ω-(3-Thienyl)Alkyl]-2,2'-Bipyridines
摘要:报告了 4-[ω-(3-噻吩基)烷基]吡啶 (2),4-[ω-(3-噻吩基)烷基]-2,2'-联吡啶 (3) 和 4-甲基-4'-[ω-(3-噻吩基)烷基]-2,2'-联吡啶 (4) 的合成,其中烷基链的长度是变化的(n = 2,5,7,9,11).合成方法是将 3-(ω-溴烷基)噻吩与来自 4-甲基吡啶,4-甲基-2,2'-联吡啶或 4,4'-二甲基-2,2'-联吡啶的阴离子通过石化作用进行反应.讨论了这些化合物的 N.M.R.(1H 和 13C)和电子光谱特性.
Doi:10.1071/ch9951425

专利信息

专利号:US-6252082-B1
优先权日:1997-01-16
标 题 :Pyridone derivatives, their preparation and their use as synthesis intermediates
发明人：LASSALLE GILBERT; BELLEVERGUE PATRICE; BOURBIER JEAN-CLAUDE; GALTIER DANIEL; MARTIN VALERIE
权利人:SANOFI SYNTHELABO
摘要:The invention concerns compounds of formula (I)in which: R is -NO2 or -NHR3, R3 being hydrogen, -COR4 (R4 selected among (C1-C4) alkyl, aryl and aryl (C1-C4) alkyl, -COOR5 (R5 selected among (C1-C4) alkyl and aryl (C1-C4) alkyl), -CONHR6 or SO2R6 (R6 selected among (C1-C5) alkyl, aryl and aryl(C1-C4) alkyl), -SO2NR7R8 (R7 and R8 independently of each other represent hydrogen or (C1-C4) alkyl or form with the nitrogen atom a morpholine group), aryl (C1-C4) alkyl, R1 is a (C1-C4) alkyl group linear or branched, cyclo (C3-C8) alkyl, aryl optionally substituted, aryl (C1-C4) alkyl optionally substituted, heteroaryl, R2 is a hydrogen atom, a (C1-C4) alkyl or arylmethyl group, X is an oxygen or sulphur atom, a -CH2-, -SO2 or -NR1- group and Y is a hydrogen atom or (C1-C6) alkyl. The invention is applicable to synthesis intermediates.

专利号:US-9249154-B2
优先权日:2008-01-08
标题:Compounds and therapeutic use thereof for protein kinase inhibition
发明人：WU ZHANGGUI
权利人:WU ZHANGGUI
摘要:Novel compound having the following formula: n nAlso disclosed are a pharmaceutical compositions comprising the same, methods for treating cancer using the same, and methods for the synthesis of the same. The novel compounds of the present invention are found to inhibit protein kinases, especially Checkpoint kinase Chk1/Chk2.

专利号:US-6166003-A
优先权日:1999-02-17
标 题 :Heterocyclic compounds for cancer chemoprevention
发明人：LAM LUKE K T
权利人:LKT LAB INC
摘要:A compound comprising a heterocyclic moiety, such as a thiophene, covalently attached to an alkylene isothiocyanate moiety. The compound is effective to prevent the occurrence or progression of cancer or a precancerous condition, and can be used for therapeutic or prophylactic purposes. The compound can be provided and administered in the form of a pharmaceutical composition, a cosmetic, a food additive, supplement, or the like. Methods for synthesis and use of the chemopreventive compound of the invention are also provided.

专利号:US-2025270240-A1
优先权日:2024-02-23
标 题 :Organometallic compositions with polyene ligands, radiation sensitive coatings with bridging organic ligands and patterning
发明人：JILEK ROBERT E; REED CHRISTOPHER J; VOSS MATTHEW
权利人:INPRIA CORP
摘要:Organometallic precursor compositions containing a polyene ligand, such as a diene ligand, are described. Corresponding films are also described and show promising solubility behavior. A synthesis technique is described for forming a polyene-containing organotin trialkoxide compound. The incorporation of polymerization inhibitors and/or blends of organotin compounds with different ligands are described as a way to design radiation sensitive films to have target solubility properties.