CAS: 3374-05-8; Sodium 1-Ethyl-7-Methyl-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylate

该化合物是一种合成抗菌剂,属于丙酮类抗生素,主要用于治疗易受细菌感染的尿道感染,其特点是能够抑制细菌DNA甘蓝酶,这是一种对DNA复制和转录至关重要的酶,因此对DNA具有抗微生物效应.氨酸钠盐通常作为白色的白色脱白晶状粉,溶于水中,可提高其用于治疗的生物利用率.该物质的毒性特征相对较低,但由于细菌抗药性的发展,其使用一般限于特定感染.必须指出,虽然氨基酸对某些克状阴性细菌有效,但对某些克状阴性细菌则不那么有效.建议对所有抗生素进行适当的感应力测试,以确保功效和尽量减少抗药性发育.此外,潜在的副作用可能包括胃肠扰动和高敏敏反应,因此在治疗期间需要仔细监测.

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nalidixic Acid-3-oxy>methyl>-8-oxo-7--5-thia-1-azabicyclo°Ct-3-ene-2-carboxylic acid2R-(2α,6α,7β)-3-(1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridin-3-yl)carbonyloxymethyl-8-oxo-7-(phenoxyacetyl)amino-5-thia-1-azabicyclo4.2.0°Ct-3-ene-2-carboxylic acid -3-oxy>methyl>-8-oxo-7--5-thia-1-azabicyclo°Ct-3-ene-2-carboxylic acid (4-nitrophenyl)methyl ester2R-(2α,6α,7β)-3-(1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridin-3-yl)carbonyloxymethyl-8-oxo-7-(phenoxyacetyl)amino-5-thia-1-azabicyclo4.2.0°Ct-3-ene-2-carboxylic acid (4-nitrophenyl)methyl ester oxy>methyl>-8-oxo-7--5-thia-1-azabicyclo°Ct-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester(6R-trans)-3-(1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridin-3-yl)carbonyloxymethyl-8-oxo-7-(phenoxyacetyl)amino-5-thia-1-azabicyclo4.2.0°Ct-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid (6R,7R)-2-tert-butoxycarbonyl-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-en-3-ylmethyl ester

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    专利信息


    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    专利号:RU-2763317-C2
    优先权日:2017-06-14
    标 题:METHOD FOR PRODUCING CHEMICAL PRODUCTS OF SUBTLE SYNTHESIS USING CORYNEBACTERIUM SECRETING MODIFIED a-1,6-GLUCOSIDASES

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    主要参考文献


    1: Callao V, Ramos A. Actividad antibacteriana del ácido nalidíxico (Win 18320) frente a diversas estirpes de gram-negativos [Antibacterial activity of nalidixic acid (WIN 18320) on various strains of Gram-negative organisms]. Microbiol Esp. 1966 Apr-Jun;19(2):173-82. Spanish.
    48:283-7. Portuguese.

    合成参考文献


    参考文献:10.1007/s00284-017-1289-8
    摘要:Gotor-Vila A, Teixidó N, Sisquella M, Torres R, Usall J. Biological Characterization of the Biocontrol Agent Bacillus amyloliquefaciens CPA-8: The Effect of Temperature, pH and Water Activity on Growth, Susceptibility to Antibiotics and Detection of Enterotoxic Genes. Curr Microbiol. 2017 Sep;74(9):1089–99. doi: 10.1007/s00284-017-1289-8.
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