CAS: 2488-15-5; Boc-Met-Oh
该化合物是L-methionine受保护的衍生物,其特性为三丁氧碳基(Boc)组,该组可增强peptide合成的稳定性和选择性. Boc组作为α-氨功能的临时保护性,允许在温酸条件下有控制的去保护,而不影响其他敏感功能组.该化合物在固相peptide合成(SPPS)和其他需要正方位保护战略的应用中特别宝贵.其高纯度和一贯性能使它成为医药化学和生物化学研究人员的可靠选择.甲基硫醚的侧端链在甲基磷中的存在进一步使其得以用于涉及氧化敏感性改变或金属协调的研究.
相似化合物
93000-03-4 5241-66-7 42537-72-4物理性质
- 熔点47-53 °C
- 沸点415.5 °C at 760 mmHg
- 闪点205.1±27.3°C
- 密度1.2±0.1 g/cm3
- PH:-23 º (c=1.3, methanol)
- pKa:3.83±0.10(预测)
- PSA:75.63
- LogP:1.7174
- 旋光度-23º(C=1.3,METHANOL)
- 折射率1.500
- 蒸汽压0.0±2.1 mmHg at 25°C
- 溶解性Almost Transparency In Methanol
- 敏感性常温常压下稳定，避免氧化剂接触，
- 外观形态白色至类白色粉末
- 储存条件置于阴暗处,密封, 常温干燥保存
- 产品应用该化合物用作生化试剂和浸泡物合成.
- 性质描述熔点47-53°C,比旋光度-23º(C=1.3,METHANOL
MSDS等安全信息
- GHS象形图
- GHS符号GHS05;
注释: Corrosion - 危险类别严重眼损伤 类别1
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2A - 警示词Danger(危险)
- 危险描述H318 |造成严重眼损伤.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- UN编号NONH for all modes of transport
- 危险品标志Xn
- 安全声明24/25-36-26
- 危险类别码20/21/22-36/37/38
- WGK Germany3.0
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号63-68-3 L-蛋氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号34619-03-9 碳酸二叔丁酯 | CAS号98015-52-2 tert-butyl 1,2,... | CAS号130384-98-4 1-叔丁氧羰基苯并三唑 | CAS号71989-28-1 Fm°C-L-蛋氨酸 | CAS号75844-68-7 TERT-BUTYL 2,3-... | CAS号1070-19-5 Carbonazidic ac... | CAS号22823-50-3 N-叔丁氧羰基-L-蛋氨酸二环己胺盐 | CAS号59880-97-6 酪胺盐酸盐 | CAS号34306-42-8 (S)-2-(B°C-氨基)丁酸 | CAS号33507-63-0 P物质 | CAS号502-83-0 DL-蛋氨醇 | CAS号51372-93-1 B°C-氨醇 | CAS号91177-57-0 (R)-(1-羟基-4-(甲硫... | CAS号3845-64-5 N-(叔丁氧羰基)-L-蛋氨酸... | CAS号879499-96-4 1,1-dimethyleth... | CAS号632-22-4 四甲基脲 | CAS号63-68-3 L-蛋氨酸合成工艺路线路线简述
- 合成目标产物 Boc-L-Methionine 主要起始原料 L-Methionine And Di-Tert-Butyl Dicarbonate
- (文献来源)合成步骤主要原料 L-Methionine 和 Di-Tert-Butyl Dicarbonate
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于三甲基氢氧化锡体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 9.0H,以90%的收率获得boc-L-蛋氨酸
参考文献:氢氧化三甲基锡选择性地分离merrifield,Pam和wang树脂中boc保护的氨基酸和肽
标题:氢氧化三甲基锡选择性地分离merrifield,Pam和wang树脂中boc保护的氨基酸和肽
摘要:我们描述了一种新的非酸解性和非亲核性方法的发展,该方法用于通过三甲基锡氢氧化物选择性地切割氨基酸和二肽在与酯合成中常用的树脂连接的苄基酯键处进行选择性切割.
Doi:10.1016/s0040-4020(98)00805-9
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2010210474-A1
优先权日:2007-09-17
标 题:Heterocyclic scaffolds useful for preparation of combinatorial libraries, libraries and methods for preparation thereof
发明人：GELLERMAN GARY
权利人:GELLERMAN GARY
摘要:Disclosed are heterocyclic scaffolds useful, for example, for solid-phase organic synthesis of combinatorial libraries and methods for the preparation thereof. Also disclosed are libraries, including combinatorial libraries, and methods for preparation thereof. Exemplified are the following scaffolds (I):
专利号:WO-2014190533-A1
优先权日:2013-05-31
标 题 :Platinum ligand and complex thereof
发明人：ZANG LINQUAN; GUO YANMING; CHEN LIANG
权利人:UNIV GUANGDONG PHARM; LONZA GUANGZHOU RES AND DEV CT LTD
摘要:Provided are a ligand having the structure of formula (I) and a complex formed by platinum and the ligand, wherein the ligand is simple in structure, capable of coupling with a variety of reagents, has a low synthesis cost and good targeting, and thus can be used for targeted therapy and diagnosis of tumours.
专利号:CN-103421087-A
优先权日:2013-04-12
标 题 :A liquid phase synthesis method of polypeptide
专利号:CN-1241935-C
优先权日:2003-06-10
标 题 :A kind of Thymopentin liquid-phase synthesis method
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Alkyl 1-Chloroalkyl Carbonates: Reagents For The Synthesis Of Carbamates And Protection Of Amino Groups作者:Gérard Barcelo,Jean-Pierre Senet,Gérard Sennyey,Jean Bensoam,Albert Loffet
摘要:The Synthesis Of 1-Chloroalkyl Carbonates And Their Reaction With Various Type Of Amines Are Described. This Reaction Is Useful For The Synthesis Of Carbamate Pesticides And For The Protection Of Various Amino Groups, Including Amino Acids.
合成参考文献
摘要:Zhou, Q.-Q.; Wei, Y.; Lu, L.-Q.; Xiao, W.-J., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 168.
摘要:Zhou, Q.-Q.; Wei, Y.; Lu, L.-Q.; Xiao, W.-J., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 173.
摘要:Lee, B. C.; Lin, L.; Ko, C.; Koh, M. J., Science of Synthesis: Special Topics, (2022) 1, 505.
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