CAS: 2480-23-1; N-Methyl-L-Valine

该化合物是一种氨酸衍生物,其特征是附于valine 侧链氮原子的甲基组,它是一种手性化合物,以两种对应形式存在,L形具有生物相关性.该物质由于其疏水性侧链,通常被归类为非极性,脂性氨基酸.N-Me乙-L-valine经常用于peptide合成,并用作制药和生化化学品开发的一个构件.其结构改变可影响Peptides的特性,例如稳定性和生物活性.该化合物在有机溶剂中溶解,水中溶解度有限,这在非极性氨基酸中很常见.此外,N-Me乙-L-valine可以参与各种化学反应,包括电热和烷基,使其成为有机合成的灵敏化中间体.与许多氨基酸一样,它在蛋白质结构和功能中扮演了作用,特别是在Pepide设计和修改过程中.

结构式图片

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CAS号124-38-9 二氧化碳 | CAS号78-84-2 异丁醛 | CAS号74-89-5 氨基甲烷 | CAS号3339-44-4 N-甲基-L-缬氨酸甲酯盐酸盐 | CAS号42417-65-2 Cbz-L-N-Me-缬氨酸 | CAS号45170-31-8 B°C-N-甲基-L-缬氨酸 | CAS号2812-32-0 N,N-二甲基-L-缬氨酸 | CAS号53978-73-7 Z-N-甲基-D-缬氨酸 | CAS号408507-19-7 4-Methyl-3-(met... | CAS号5616-88-6 2-phenoxyethyl ...

合成工艺路线路线简述

  • 84000-11-3 = 2480-23-1
    反应条件:1.1 Reagents: Piperidine Solvents: Methanol
    标题:Structure Elucidation And Synthesis Of Natural Products
    作者:Murphy,Annabel Christine
    参考文献:2008]

    72-18-4 = 2480-23-1
    反应条件:1.1 Reagents: 2-Nitrobenzaldehyde,Sodium Cyanoborohydride Solvents: Water; Ph 51.2 Reagents: Sodium Cyanoborohydride Solvents: Water; Ph 5
    标题:Transformation Of Aminoacyl Trnas For The In Vitro Selection Of "Drug-Like" Molecules
    作者:Merryman,Chuck; Green,Rachel
    参考文献:Chemistry & Biology 日期:2004 卷标:11(4) 页码:575-582]

    60522-09-0 = 2480-23-1
    反应条件:1.1 Reagents: Phenol,Hydrogen Bromide Solvents: Water
    标题:Amino Acids And Peptides. Part Ccv. An Alternative Route To Nα-Methylamino Acid Derivatives. Synthesis And Conformation Of Some Nα-Acetyl-Nα-Methylamino Acid Methylamides
    作者:Hlavacek,Jan; Fric,Ivo; Budesinsky,Milos; Blaha,Karel
    参考文献:Collection Of Czechoslovak Chemical Communications 日期:1988 卷标:53 页码:2473-94]

    98275-68-4 = 2480-23-1 + 865245-08-5
    反应条件:1.1 Reagents: Tripotassium Phosphate Solvents: Water; 30 Min,30 °C1.2 4 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 3 - 4
    标题:Synthesis Of Optically Active α-Methylamino Acids And Amides Through Biocatalytic Kinetic Resolution Of Amides
    作者:Wang,Mei-Xiang; Liu,Jun; Wang,De-Xian; Zheng,Qi-Yu
    参考文献:Tetrahedron: Asymmetry 日期:2005 卷标:16(14) 页码:2409-2416
📜Selaginemine A置于盐酸体系中,用 甲醇,水 用作溶剂,化学反应 17.0H,反应生成N-甲基-L-缬氨酸
参考文献:Antifungal Compound Against Azole-Resistant Candida Albicans From A Marine-Derived Fungus,Paraboeremia Selaginellae
标题:Antifungal Compound Against Azole-Resistant Candida Albicans From A Marine-Derived Fungus,Paraboeremia Selaginellae
摘要:
Doi:10.3987/com-20-14229

海关参考信息

专利信息


专利号:US-2023313255-A1
优先权日:2020-07-15
标题:Massively Parallel Enzymatic Synthesis of Polynucleotides
发明人:HORGAN ADRIAN; LACHAIZE HENRI; VERARDO DOMIANO; GODRON XAVIER
权利人:DNA SCRIPT
摘要:The invention is directed to methods and compositions for inkjet assisted synthesis of a plurality of polynucleotides at reaction sites on a substrate using template-free polymerases, such as, terminal deoxynucleotidyl transferases (TdTs). Compositions of the invention include formulations of synthesis reagents for inkjet delivery including, but not limited to, TdT coupling reaction buffers and 3′-O-protected dNTP monomers.

专利号:WO-9517903-A1
优先权日:1993-12-28
标 题:Modular design and synthesis of oxazolone-derived molecules
发明人:HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
权利人:ARQULE PARTNERS L P; HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
摘要:The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.

专利号:US-6376649-B1
优先权日:1998-12-18
标题 :Methods for the synthesis of α- hydroxy-β-amino acid and amide derivatives
发明人:SEMPLE JOSEPH E; LEVY ODILE E
权利人:CORVAS INT INC
摘要:Methods for the synthesis of alpha-hydroxy-beta-amino acid and amide derivatives and alpha-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehyde with an isonitrile and a carboxylic acid to give an amino-alpha-acyloxy carboxamide. The acyloxy group may be removed to give the derivative. Alternatively the protecting group is removed and acyl shift occurs to give the derivative. These derivatives are useful in the synthesis of compounds such as peptidyl alpha-ketoamides and alpha-hydroxy-beta-carboxylic acid and amide derivatives. Certain of these compounds have been reported to have activity as inhibitors of proteases, such as serine proteases and cysteine proteases.

专利号:US-11905541-B2
优先权日:2019-02-12
标 题:Efficient product cleavage in template-free enzymatic synthesis of polynucleotides
发明人:CRETON SANDRINE
权利人:DNA SCRIPT SAS
摘要:The present invention is directed to methods and kits for template-free enzymatic synthesis of polynucleotides that include or enable a step of efficiently cleaving the polynucleotide products from its initiator using an endonuclease V activity and initiator with a 3′-penultimate deoxyinosine.

专利号:US-9938509-B2
优先权日:2010-12-08
标 题 :Biocatalysts and methods for the synthesis of armodafinil
发明人:ANG EE LUI; ALVIZO OSCAR; BEHROUZIAN BEHNAZ; CLAY MICHAEL D; COLLIER STEVEN J; EBERHARD ELLEN D; FAN FU; SONG SHIWEI; SMITH DEREK J; WIDEGREN MAGNUS; WILSON ROBERT; XU JUNYE; ZHU JUN
权利人:CODEXIS INC
摘要:The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.

专利号:US-2024052391-A1
优先权日:2020-10-29
标 题 :Enzymatic Synthesis of Polynucleotide Probes
发明人:GODRON XAVIER; NIYOMCHON SUPAPORN; CHAMPION ELISE
权利人:DNA SCRIPT
摘要:The present invention is directed to methods and kits for enzymatic synthesis of labeled polynucleotide probes using template-free DNA polymerases.

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主要参考文献

[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

合成参考文献


参考文献:10.1007/s004200050353
摘要:Boogaard PJ, Rocchi PSJ, van Sittert NJ. Biomonitoring of exposure to ethylene oxide and propylene oxide by determination of hemoglobin adducts: correlations between airborne exposure and adduct levels. International Archives of Occupational and Environmental Health. 1999 May 11;72(3):142–50. doi: 10.1007/s004200050353.
参考文献:10.1021/np070346o
摘要:Adams B, Pörzgen P, Pittman E, Yoshida WY, Westenburg HE, Horgen FD. Isolation and structure determination of malevamide E, a dolastatin 14 analogue, from the marine cyanobacterium Symploca laete-viridis. J Nat Prod. 2008 May;71(5):750–4. doi: 10.1021/np070346o.
参考文献:10.1007/s00294-003-0479-z
摘要:Guillemette T, Sellam A, Simoneau P. Analysis of a nonribosomal peptide synthetase gene from Alternaria brassicae and flanking genomic sequences. Curr Genet. 2004 Apr;45(4):214–24. doi: 10.1007/s00294-003-0479-z.
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