CAS: 2367004-54-2; N-(4-Fluorophenyl)-N-(4-((7-Methoxy-6-(Methylcarbamoyl)Quinolin-4-yl)Oxy)Phenyl)Cyclopropane-1,1-Dicarboxamide
- 英文名称N-(4-Fluorophenyl)-N-(4-((7-Methoxy-6-(Methylcarbamoyl)Quinolin-4-yl)Oxy)Phenyl)Cyclopropane-1,1-Dicarboxamide
- 中文名称N-(4-氟苯基)-N-(4-((7-甲氧基-6-(甲基氨基甲酰基)喹啉-4-基)氧基)苯基)环丙烷-1,1-二甲酰胺
- IUPAC名称N-(4-fluorophenyl)-N-(4-((7-methoxy-6-(methylcarbamoyl)quinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
- CAS编号2367004-54-2
- MFCD编号:MFCD34179545
- FDA UNII编号:KC2JC2ZA04
- 分子式:C29H25FN4O5分子量:528.54
- 产品CID: 2177548
- 产品分类Protein Tyrosine Kinase/RTK → VEGFR | Quinolines | Protein Tyrosine Kinase/RTK → c-Met/HGFR | Ethers | Protein Tyrosine Kinase/RTK → TAM Receptor | Aromatic Heterocycles
物理性质
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海关参考信息
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主要参考文献
1: Yu J, Park R, Tojjari A, Sadeghipour A, Saeed A, Saeed A. Zanzalintinib (XL092): a next-generation tyrosine kinase inhibitor-comprehensive review of early safety & efficacy data. Expert Opin Investig Drugs. 2024 Sep;33(9):887-895. doi: 10.1080/13543784.2024.2388571. Epub 2024 Aug 7. 20(24):1733-1743. doi: 10.1080/14796694.2024.2352276. Epub 2024 Jul 23.
合成参考文献
参考文献:10.1016/j.jpba.2021.114390
摘要:Yuan L, Li J, Feng M, Zou X. Identification of the metabolites of XL092 in rat and human by using ultra-high performance liquid chromatography high resolution mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2021 Nov;206():114390. doi: 10.1016/j.jpba.2021.114390.
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