CAS: 22838-58-0; Boc-D-Val-Oh

相似化合物

54895-12-4 103478-58-6 1149-26-4

上下游产品

2-iodo-propane B°C-glycine rac-tert-butyl (1-hydroxy-3-methylbutan-2-yl)carbamate tert-butyl dicarbonatedi-tert-butyl dicarbonate2-tert-Butoxycarbonylamino-3-methyl-butyric acid pentafluorophenyl ester B°C-D-Val-Lac-OH B°C-D-Val-Lac-OBzl N-tert.-Butyloxycarbonyl-D-valin-(R)-1-benzyloxycarbonyl-2-methyl-propylester

Tert-Butyl N-[(1R)-1-[(4S,5S)-2,2-Dimethyl-5-Phenyl-1,3-Dioxolan-4-Yl]-2-Methylpropyl]Carbamate置于四氯化钌 盐酸,Sodium Periodate体系中,用 甲醇 用作溶剂,化学反应生成Boc-D-缬氨酸
参考文献:通过2,3-二烷氧基腈的还原烷基化非对映选择性合成3-氨基-1,2-二醇
标题:通过2,3-二烷氧基腈的还原烷基化非对映选择性合成3-氨基-1,2-二醇
摘要:将格氏试剂添加到丙酮化物保护的顺式2,3-二羟基腈中,然后还原所得的镁亚胺,以高对映体纯度提供所有的顺式1,3-二取代的3-氨基-1,2-二醇.
Doi:10.1016/s0040-4039(00)00202-1

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-9710221-A1
优先权日:1995-09-15
标 题:Synthesis of quinazolinone libraries
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TORREY PINES INST
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-9834113-A1
优先权日:1997-02-04
标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; HOUGHTEN RICHARD A; BLONDELLE SYLVIE E; SCHONER CHRISTA C
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-6359144-B1
优先权日:1997-02-04
标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
权利人:LION BIOSCIENCE AG
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-4202802-A
优先权日:1978-10-02
标 题 :Peptides related to somatostatin
发明人：SHIELDS JAMES E
权利人:LILLY CO ELI
摘要:The tetradecapeptides of the formula wherein X is H-Ala-D-Ala, H-D-Ala-Gly, or H-D-Val-Gly; and X is Ala-Leu, Ala-Phe, Ala-D-Phe, D-Ala-Phe, or D-Ala-Cha; or the non-toxic, pharmaceutically acceptable acid addition salts thereof; inhibit secretion of growth hormone, while not materially inhibiting the secretion of insulin or glucagon. Intermediates used in the synthesis of the tetradecapeptides are also described.