专利号:US-2013338369-A1 优先权日:2011-03-07 标 题 :Process for the Synthesis of Aminobiphenylene 发明人:HEINRICH MARKUS; PRATSCH GERALD 权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE 摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
专利号:US-2013184465-A1 优先权日:2010-09-30 标 题:Process for the synthesis of thio-triazolo-group containing compounds 发明人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL 权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE 摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.
专利号:US-7820831-B2 优先权日:2002-09-11 标 题:Compounds comprising a thiocarbonyl-sulfanyl group which can be used for the radical synthesis of α-perfluoroalkylamine compounds 发明人:ZARD SAMIR; GAGOSZ FABIEN; TOURNIER LUCIE 权利人:CENTRE NAT RECH SCIENT 摘要:The invention relates to compounds having the general formula (I), the method of preparation thereof and the use thereof in organic radical synthesis. The invention also relates to compounds having the formula (II), the method of preparation thereof and a method for preparing compounds having the formula (VIII).
专利号:US-4273947-A 优先权日:1979-01-31 标 题:Hydrogenation of fluorine-containing carboxylic acids 发明人:NOVOTNY MIROSLAV 权利人:ALLIED CHEM 摘要:A process is described for the heterogeneous hydrogenation of fluorine-containing alkyl, cycloalkyl, and benzene carboxylic acids to the corresponding primary alcohols. The hydrogenation can be carried out in the liquid or vapor phase in the presence of a solid rhodium or iridium catalyst, employed as the metal, metallic oxide, or mixture thereof. In the liquid phase, the hydrogenation can be carried out batchwise under mild conditions of temperature and pressure, preferably at about 50°-150° C. and about 5-15 atmospheres, in an atmosphere containing hydrogen gas. A preferred embodiment is the hydrogenation of trifluoroacetic acid in the liquid phase to 2,2,2-trifluoroethanol, said alcohol being useful as an intermediate in the synthesis of the anesthetic, isoflurane, CF 3 CHClOCHF 2 .
专利号:US-10919921-B2 优先权日:2016-05-06 标题:P-chiral phosphine ligands and use thereof for asymmetric synthesis 发明人:BOERNER ARMIN; HOLZ JENS; RUMPEL KATHARINA 权利人:BASF SE 摘要:The present invention relates to chiral compounds with two optically active phosphorus atoms, chiral transition metal catalysts which comprise these compounds as ligands, a process for preparing the P-chiral compounds and processes for asymmetric synthesis using the chiral transition metal catalysts. The present invention specifically relates to a process for preparing an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of an optically active transition metal catalyst according to the invention. Yet more specifically, the present invention relates to a process for the asymmetric hydrogenation of citral, and also a process for preparing optically active menthol.
专利号:US-2023158176-A1 优先权日:2021-11-23 标题:Near-infrared fluorescent small-molecule probe, synthesis method and application thereof 发明人:QU ZONGJIN; LI HAN; WANG ZHEN; ZHANG SHUSHENG 权利人:UNIV LINYI 摘要:A near-infrared fluorescent small-molecule probe, a synthesis method thereof, and an application thereof are provided. The near-infrared fluorescent small-molecule probe is IR-780-F derived from IR-780, in which the basic structure of IR-780 is retained, an end of an alkyl carbon chain connected with a nitrogen (N) atom is changed by adding a trifluoromethyl group (—CF3) at the end. The IR-780-F shows excellent performance in photostability, targeting cancer cells and fluorescence imaging, and has low toxicity. It can be used for targeting tumor tissues, in vivo near-infrared fluorescence imaging, and photothermal therapy, which realizes an integration of diagnosis and treatment.