CAS: 214475-53-3; Fmoc-4-Hydrazinobenzoic Acid

上下游产品

CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号619-67-0 4-肼基苯甲酸

📜氯甲酸-9-芴基甲酯,4-肼基苯甲酸置于碳酸氢钠体系中,用 1,4-二氧六环 用作溶剂,以75%的收率获得4-(2-氨基保护羧基)苯甲酸
参考文献:芳酰肼作为固相合成的连接基,可在温和的氧化条件下裂解
标题:芳酰肼作为固相合成的连接基,可在温和的氧化条件下裂解
摘要:我们已经开发了酸/碱稳定的芳基酰肼连接基,该连接基很容易与固相树脂偶联.切割是特定且容易的,需要铜(II)催化剂,碱和亲核试剂进行.该条件与所有20种蛋白原氨基酸均相容,并在20oc下2小时内完成定量切割,从而得到具有c端酸,酰胺或酯官能团的肽.芳基酰肼也可作为简单的"无痕"连接剂提供作用域.
Doi:10.1016/s0040-4039(98)01543-3

专利信息

专利号:US-11186608-B2
优先权日:2017-12-21
标 题 :Solid phase synthesis of acylated peptides
发明人：SCHOENLEBER RALPH O; LOIDL GUENTHER
权利人:BACHEM HOLDING AG
摘要:The present invention relates to methods and compounds for the solid phase synthesis of peptides carrying a substituent at an amino group of an amino acid side chain.

专利号:US-12006541-B2
优先权日:2021-05-07
标题:Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids
发明人：LEE FRANCIS; STECKBECK JONATHAN D; HOLSTE HANNES
权利人:PEPTILOGICS INC C; PEPTILOGICS INC
摘要:In one aspect, a computer-implemented automated flow synthesis platform configured to use an artificial intelligence (AI) engine is disclosed and includes a reaction chamber configured to synthesize a sequence, detectors configured to monitor the synthesis of the sequence in the reaction chamber, wherein the synthesis uses an automated flow process, and a computing device communicatively coupled to the detectors. The computing device receives measurements from the one or more detectors, wherein the measurements comprise a spectral profile at each coupling of each amino acid in the sequence, trains, using training data comprising the measurements, machine learning models to determine a synthesizing recipe that enables the sequence to be synthesized, wherein the synthesizing recipe comprises parameters used during the automated flow process to synthesize the sequence, and controls, using the synthesizing recipe, the synthesis of the sequence in the reaction chamber.

专利号:US-11587643-B2
优先权日:2021-05-07
标 题 :Methods and apparatuses for a unified artificial intelligence platform to synthesize diverse sets of peptides and peptidomimetics
发明人：LEE FRANCIS; STECKBECK JONATHAN D; HOLSTE HANNES
权利人:PEPTILOGICS INC
摘要:In one aspect, a method is disclosed wherein an artificial intelligence (AI) enabled automated flow synthesis platform is configured to generate optimized synthesizing recipes which enable a sequence to be synthesized using an automated flow process. The method includes receiving a synthesizing recipe including parameters used during the automated flow process to synthesize the sequence, receiving spectral data from detectors monitoring the automated flow process in a reaction chamber, where the spectral data corresponds to a reaction point in the automated flow process, and determining, based on indicators associated with the spectral data, characteristics of a chemical reaction at the reaction point in the automated flow process. An artificial intelligence engine determines the chemical reaction. The method includes associating, based on the spectral data, the synthesizing recipe with the chemical reaction.

专利号:EP-3728304-A1
优先权日:2017-12-21
标题 :Solid phase synthesis of acylated peptides

专利号:US-2021009631-A1
优先权日:2017-12-21
标 题:Solid phase synthesis of acylated peptides

专利号:EP-3728304-B1
优先权日:2017-12-21
标题 :Solid phase synthesis of acylated peptides