CAS: 19026-31-4; Taxodione

📜6β-Hydroxyferruginol置于lithium Aluminium Tetrahydride,Jones Reagent体系中,用 四氢呋喃,氯仿,丙酮 用作溶剂,化学反应 49.58H,反应生成落羽松二酮
参考文献:Synthesis Of Variously Oxidized Abietane Diterpenes And Their Antibacterial Activities Against Mrsa And Vre
标题:Synthesis Of Variously Oxidized Abietane Diterpenes And Their Antibacterial Activities Against Mrsa And Vre
摘要:Variously Oxidized 12 Natural Abietanes,6,7-Dehydroferruginol Methyl Ether (3),Ferruginol (5),11-Hydroxy-12-Oxo-7,9(11),13-Abietatriene (7),Royleanone (9),Demethyl Cryptojaponol (12),Salvinolone (14),Sugiol Methyl Ether (16),Sugiol (17),5,6-Dehydrosugiol Methyl Ether (19),5,6-Dehydrosugiol (20),6 Beta-Hydroxyferruginol (23),And Taxodione (25) Were Synthesized. Antimicrobial Activities Of Synthesized Phenolic Diterpenes And Their Related Compounds Against Mrsa And Vre Were Evaluated. Phenols (12-Hydroxyabieta-8,11,13-Trien-6-One 22 And 23),Catechols (12 And 14) And Taxodione 25 Showed Potent Activity With 4-10 Mug/ml Of Mic Against Mrsa And 4-16 Mug/ml Of Mic Against Vre. (-)-Ferruginol Showed More Potent Activity Than Natural Type (+)-Ferruginol. Quinone Methide 7 Showed The Most Potent Activity With 0.5-1 Mug/ml Of Mic Against Both Mrsa And Vre. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0968-0896(00)00253-4

专利信息

专利号:US-12221419-B2
优先权日:2022-03-30
标题:Abietanes and methods of making and using the same
发明人：FREDERICH JAMES H; SOLANS MEGAN M
权利人:FLORIDA STATE UNIV RESEARCH FOUNDATION INCORPORATED; UNIV FLORIDA STATE RES FOUND
摘要:In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein is versatile polyene cyclization strategy that exploits conjugated β-ionyl derivatives. Photomediated disruption of the extended Ï€-system within these chromophores unveils a contra-thermodynamic polyene that engages in a Heck-type cyclization to afford [4.4.1]-propellanes. The connectivity of overbred polycycles generated from this process is controlled by the position of the requisite C-Halide bond. Thus, compared to conventional biomimetic polyene cyclization, this approach allows for complete control of regiochemistry and facilitates incorporation of both electron-rich and electron-deficient (hetero)aryl groups. This strategy was successfully applied to the total synthesis of abietanes such as, for example, taxodione and salviasperanol, two isomeric abietane-type diterpenes that previously could not be prepared along the same synthetic pathway.

专利号:JP-H01228938-A
优先权日:1988-03-09
标题 :Asymmetric synthesis of diterpene

专利号:JP-2621309-B2
优先权日:1988-03-09
标 题 :Asymmetric synthesis of diterpenes

专利号:EP-1554304-B1
优先权日:2002-10-17
标 题 :Ship 1 modulators
发明人：ANDERSEN RAYMOND; WILLIAMS DAVID E; MUI ALICE; ONG CHRISTOPHER; KRYSTAL GERALD; YANG LU
权利人:UNIV BRITISH COLUMBIA
摘要:The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP I activity and methods of synthesis thereof.

专利号:US-8765994-B2
优先权日:2001-10-17
标 题:Ship 1 modulators
发明人：ANDERSEN RAYMOND; WILLIAMS DAVID E; MUI ALICE; ONG CHRISTOPHER; KRYSTAL GERALD; YANG LU
权利人:ANDERSEN RAYMOND; WILLIAMS DAVID E; MUI ALICE; ONG CHRISTOPHER; KRYSTAL GERALD; YANG LU; UNIV BRITISH COLUMBIA
摘要:The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof.