CAS: 15793-40-5; N-(Tert-Butyl)-4,4-Diphenylbutan-2-Amine

上下游产品

4,4'-二苯基-2-丁酮 4,4-Diphenylbutan-2-One 5409-60-9

📜溴甲苯置于降冰片烯,Schwartz'S Reagent,正丁基锂,3,5-双三氟甲基溴苯,2,2,6,6-Tetramethylpiperidinyl-Lithium,Potassium Carbonate,Cobalt(II) Aceylacetonate,三乙胺,三苯基膦,4,5-双二苯基膦-9,9-二甲基氧杂蒽,Silver(L) Oxide,Bis(Dibenzylideneacetone)-Palladium(0),Sodium T-Butanolate体系中,用 四氢呋喃,甲醇,正己烷,环己烷,N,N-二甲基甲酰胺,甲苯 用作溶剂,化学反应 70.0H,反应生成特罗地林
参考文献:钴催化末端炔烃的 1,1,3-三甲基化
标题:钴催化末端炔烃的 1,1,3-三甲基化
摘要:我们开发了一种钴催化的末端炔烃与频哪醇硼烷 (Hbpin) 的区域选择性 1,1,3-三苯甲基化反应,催化剂由容易获得且工作稳定的 Co(Acac) 2原位生成和黄磷.多种末端炔烃经历此三苯甲基化反应,以高收率和高选择性提供相应的 1,1,3-三硼烷基烷烃.该催化协议的合成效用已通过开发 1,1,3-三苯烷基烷产品的选择性逐步功能化得到证明.进行对照实验和氘标记反应,监测反应过程和识别反应中间体等机理研究的结果表明,这种 1,1,3-三硼化反应通过 Alken-1-的 1,3-二硼化进行的.由钴催化的末端炔烃的硼氢化形成的基硼酸盐.
Doi:10.1021/acs.Organomet.2C00053

专利信息

专利号:US-11725070-B2
优先权日:2018-05-09
标 题:Polymerization process for the synthesis of vinyl aromatic polymers with a controlled structure
发明人：GHELFI FRANCO; FERRANDO ANGELO; LONGO ALDO; BUFFAGNI MIRKO
权利人:VERSALIS SPA
摘要:The present invention relates to a polymerization process for the synthesis of vinyl aromatic polymers, in which the sequence of monomers in the chain and the linear, branched soluble, or crosslinked insoluble structure, with reactive or different polarity functions, are controlled. Said process comprises the step of polymerizing vinyl aromatic monomers by means of an Atom Transfer Radical Polymerization (ATRP) reaction with an Activator ReGenerated by Electron Transfer (ARGET), the reaction being carried out at a temperature comprised between 25° C. and 110° C. in an inert gas atmosphere in the presence of a complex catalyst containing a cupric halide and a multidentate amine ligand, feeding to the reaction an organic initiator having two geminal halogens, an alkali metal (bi)carbonate, a solvent pair of an aliphatic alcohol and an acetic ester of the same aliphatic alcohol and possibly ascorbic acid, provided that no initiator is used with three or more active halogens, or polyvinyl monomers or inimers.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-5554501-A
优先权日:1992-10-29
标题:Biopolymer synthesis using surface activated biaxially oriented polypropylene
发明人：COASSIN PETER J; MATSON ROBERT S; RAMPAL JANG B
权利人:BECKMAN INSTRUMENTS INC
摘要:Disclosed herein are surface activated, organic polymers useful for biopolymer synthesis. Most preferably, aminated biaxially oriented polypropylene is used for the synthesis of oligonucleotides thereto, and these devices are most preferably utilized for genetic analysis of patient samples.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-12084468-B2
优先权日:2016-09-20
标 题 :Synthesis of backbone modified morpholino oligonucleotides and chimeras using phosphoramidite chemistry
发明人：CARUTHERS MARVIN; PAUL SIBASISH
权利人:UNIV COLORADO REGENTS; UNIV COLORADO REGENTS
摘要:Amine substituted morpholino oligonucleotides, other than the classical N,N-dimethylamino PMO analogue, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. Morpholino oligonucleotides having thiophosphoramidate, phosphoramidate, and alkyl phosphoramidate linkers. Chimeras containing unmodified DNA/RNA and other analogs of DNA/RNA can be prepared. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous applications.

专利号:US-2023028994-A1
优先权日:2019-12-13
标 题 :Heterogeneous synthesis of methylene dianiline
发明人：PARVULESCU ANDREI-NICOLAE; GORDILLO BOLONIO ALVARO; DE BAERDEMAEKER TREES MARIA; MUELLER ULRICH; DE VOS DIRK; CHEUNG KA YAN
权利人:BASF SE
摘要:The present invention relates to a catalytic material for the preparation of one or more of 4,4′-methylenedianiline, 2,2′-methylenedianiline, 2,4′-methylenedianiline, and oligomers of two or more thereof, the catalytic material comprising an oxidic support, wherein the oxidic support comprises an element E OS1 selected from the group consisting of Ti, Zr, Al, Si, and mixtures of two or more thereof, and further comprising a supported material supported on the oxidic support, wherein the supported material comprises an element E SM1 selected from the group consisting of Ti, Zr, V, Nb, Ta, Mo, W, Ge, Sn, Sc, Y, La, Ce, Nd, Pr, Hf, Cr, Fe, Co, Ni, Cu Zn, Pb and mixtures of two or more thereof. Further, the present invention relates in particular to a process for the preparation of a catalytic material and to a process for the preparation of one or more of 4,4′-methylenedianiline, 2,2′-methylenedianiline, 2,4′-methylenedianiline and oligomers of two or more thereof.