CAS: 1356190-17-4; 17-(2-Chloroacetyl)-9-Fluoro-11-Hydroxy-10,13,16-Trimethyl-7,8,11,12,14,15-Hexahydro-6H-Cyclopenta[a]Phenanthren-3-One

专利信息

专利号:US-4404141-A
优先权日:1981-03-09
标 题:Δ9(11) - And Δ16 -21-chloro-20-keto steroids of the pregnane and D-homopregnane series, their preparation and use as intermediates for the synthesis of highly effective corticoids
发明人：ANNEN KLAUS; LAURENT HENRY; HOFMEISTER HELMUT
权利人:SCHERING AG
摘要:Δ 16 - and Δ 17 -21-chloro-20-keto steroids of the formula ##STR1## wherein n is 1 or 2, n C 1 C 2 and C 9 C 11 represent a CC-single or CC-double bond, n R 1 is H or OH, n R 2 is H or CH 3 , n R 3 is H or F wherein, when R 3 =F, C 9 C 11 is a CC-single bond, and n R 4 is H, CH 3 , or F, n are valuable intermediates for preparation of highly effective, known steroids. n A process for preparing these compounds involves heating the corresponding 11β- and/or 17α- or 17aα-nitrooxy-21-mesyloxy-20-keto steroids with lithium chloride in a dipolar aprotic solvent at temperatures above room temperature.

专利号:EP-0061416-B1
优先权日:1981-03-09
标题 :Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids

专利号:EP-0061416-A1
优先权日:1981-03-09
标题 :Process for the preparation of Delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and D-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids