专利号:US-6608196-B2 优先权日:2001-05-03 标题 :Process for solid supported synthesis of pyruvate-derived compounds 发明人:WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L 权利人:GALILEO PHARMACEUTICALS INC 摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.
专利号:US-6770776-B2 优先权日:1995-02-28 标 题 :Synthesis of fluorocarbon compounds 发明人:JANIN ROBERT; SAINT-JALMES LAURENT 权利人:RHONE POULENC CHIMIE 摘要:Fluorocarbon compounds are synthesized by reacting a substrate hydrocarbyl compound containing at least one sp 3 -hybridized halophoric carbon atom bearing at least two halogen atom substituents, at least one of which is a halogen atom having an atomic number greater than that of fluorine and the at least one halophoric carbon atom being bonded to at least one chalcogen, with at least one reactant which comprises a complex of a Bronstedt base with a defined amount n of hydrofluoric acid, n being at least 3 and not greater than 20.
专利号:US-2002038061-A1 优先权日:1995-02-28 标题 :Synthesis of fluorocarbon compounds
专利号:US-6316636-B1 优先权日:1995-02-28 标题 :Synthesis of fluorocarbon compounds
专利号:US-7145020-B2 优先权日:2001-04-24 标 题 :Materials and methods for treating coagulation disorders 发明人:DRUZGALA PASCAL; ZHANG XIAOMING; PFISTER JURG R 权利人:ARYX THERAPEUTICS 摘要:This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.
专利号:US-6864279-B2 优先权日:2001-04-24 标 题 :Materials and methods for treating coagulation disorders 发明人:DRUZGALA PASCAL; ZHANG XIAOMING; PFISTER JUERG 权利人:ARYX THERAPEUTICS 摘要:This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.
摘要:The Good Scents Company Information System 摘要:García Ruano, J. L.; Cid, M. B.; Martín-Castro, A. M.; Alemán, J., Science of Synthesis, (2008) 39, 299.