CAS: 103882-85-5; 4-Amino-1-((4S,5R)-3,3-Difluoro-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyrimidin-2(1H)-One

该化合物是主要用于癌症治疗领域的核素类比,是宝石的衍生物,是众所周知的乳胶化疗剂.3-Epigemcitabine结构具有一种改良的糖味结构,加强了其稳定性和对某类癌症细胞的稳定性和效力.这种复合物质通过干扰DNA合成和修复,最终导致迅速分裂的细胞出现吸附性.其行动机制包括将DNA结合,从而破坏正常的复制过程.此外,3-Epigemcitabine已经研究过,以克服癌症细胞在传统疗法下发展的抗药机制的潜力.该化合物的药性皮质学表明,它可能改善了生物利用率,降低了其与母体化合物的毒性.正在进行的研究继续探索其治疗潜力和各种癌症类型的最佳剂量疗法.

英文名称4-Amino-1-((4S,5R)-3,3-Difluoro-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyrimidin-2(1H)-One
中文名称4-氨基-1-(2-脱氧-2,2-二氟呋喃戊糖基)-2(1H)-嘧啶酮
IUPAC名称4-amino-1-((4S,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
其它别名3Epigemcitabine; 4-Amino-1-(Deoxy-2,2-Difluoro-D-Threo-Pentofuranosyl)-2(1H)-Pyrimidinon; (Gemcitabine Impurity; 3’-Epi Gemcitabine (Gemcitabine Impurity); 4-Amino-1-(Deoxy-2,2-Difluoro-D-Threo-Pentofuranosyl)-2(1H)-Pyrimidinone; Gemcitabine 3-Epimer; Gemcitabine Impurity 4(Gemcitabine 3-Epimer); Gemcitabine Hydrochloride Impuritⅱ：3'-Epi Gemcitabine
CAS编号103882-85-5
MFCD编号:MFCD09840530
分子式:C9H11F2N3O4分子量:263.2
产品CID: 74990

相似结构搜索
InChIKey: SDUQYLNIPVEERB-NKCGXFSVSA-N
InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6+,7 /m1/s1
计算化学: 氢键受体数6.0氢键供体数3.0可旋转键数2.0

MSDS等安全信息

警示词Warning
危险描述H315-H319-H361-
防范说明P201-P202-P264-P280-P302+P352-P305+P351+P338-P308+P313-P332+P313-P362+P364-P405-P501-
安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body

上下游产品

1-(2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-acetamidopyrimidin-2-one (2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate 2-deoxy-2,2-difluoro-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate 3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose gemcitabine Gemcitabine monophosphate