CAS: 98191-30-1; 3,5-Dichloro-4-Fluorobenzoic Acid

上下游产品

CAS号77227-81-7 3,5-二氯-4-氟三氟甲苯

3,5-二氯-4-氟三氟甲苯置于氯磺酸,硫酸体系中,化学反应 1.0H,以49%的收率获得产物3,5-二氯-4-氟苯甲酸
参考文献:Bioavailable Diacylhydrazine Ligands For Modulating The Expression Of Exogenous Genes Via An Ecdysone Receptor Complex
标题:Bioavailable Diacylhydrazine Ligands For Modulating The Expression Of Exogenous Genes Via An Ecdysone Receptor Complex
摘要:本发明涉及用于核受体基于诱导基因表达系统的非甾体配体,以及一种调节外源基因表达的方法,其中包括一个包含:Dna结合结构域;配体结合结构域;转活化结构域;和配体的ecdysone受体复合物与包含外源基因和响应元件的dna构建物接触;其中外源基因受响应元件控制,并且在配体存在的情况下dna结合结构域与响应元件结合导致基因的激活或抑制.

专利信息

专利号:US-11091490-B2
优先权日:2016-11-30
标 题:3-amino-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-ones as cyclin dependent kinase inhibitors
发明人：WUNDERLECH WINFRIED; HUBER LUKAS A; LEBAN JOHANN JAKOB; PATÓ Jà NOS; ÖRFI Là SZLÓ; FRIGYES Wà CZEK; Bà NHEGYI PÉTER; Sà POS ANNA; SZà NTAI-KIS CSABA
权利人:ONCOTYROL CENTER FOR PERSONALIZED CANCER MEDICINE GMBH; VICHEM CHEMIE KUTATO KORLATOLT FELELOESSEGUE TARSASAG; MEDIZINISCHE UNIV INNSBRUCK
摘要:The present invention relates to 3-amino-pyrazolo[3,4-d]pyrimidin-4-ones, such as for example, N-{4-[1-(2,6-dichloro-4-sulfamoyl-phenyl)-3-dimethylamino-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylmethyl]-phenyl}-2-diethylamino-acetamide, particularly useful as cyclin dependent kinase (CDK) inhibitors, pharmaceutical compositions comprising the same and the use thereof in particular in the prophylaxis and/or treatment of cancer and other proliferative diseases. Furthermore, the present invention relates to processes for the synthesis of said 3-aminopyrazolo[3,4d]pyrimidin-4-ones and intermediates to be used in the processes of the present invention.