CAS: 94487-74-8; (Z)-2-Methylbut-2-Enoic Anhydride

该化合物是一种有机化合物,其特征为双份联结配置和酯功能组,其特点是五碳链,配有与第二碳相连的甲基组,第二和第三碳双份联结,这种组合在Z(Cis)配置中,影响其物理特性,如沸点和溶解性.该化合物一般是一种无色液体,有水果味,有可能用于调味和香味应用.其再活性主要归因于双份联结的存在,它可以参与各种化学反应,包括聚合和添加反应.作为酯,它也可以在水和酸或碱存在时进行水解,导致形成相应的酸和酒精.在处理和储存时,应参考安全数据,与所有化学物质一样,确保采取适当的防范措施.

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CAS号75567-37-2 丁烯英酯 | CAS号52617-35-3 [(3aR,4S,7aR)-6...

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  • 565-63-9 = 94487-74-8
    反应条件:1.1 Solvents: Dichloromethane; Rt1.2 Reagents: Dicyclohexylcarbodiimide Solvents: Xylene; 1 H,Rt
    标题:A Method Of Producing Ingenol-3-Angelate From Ingenol
    参考文献:World Intellectual Property Organization]

    565-63-9 = 94487-74-8
    反应条件:1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Dichloromethane,Xylene; 1 H,Rt
    标题:Semisynthesis Of Ingenol 3-Angelate (Pep005): Efficient Stereoconservative Angeloylation Of Alcohols
    作者:Liang,Xifu; Grue-Soerensen,Gunnar; Petersen,Anders Klarskov; Hogberg,Thomas
    参考文献:Synlett 日期:2012 卷标:23(18) 页码:2647-2652
📜依替前列通置于n,N'-二环己基碳二亚胺体系中,用 二氯甲烷 作为反应溶剂,以83.3 %的收率获得产物白芷酸酐
参考文献:苋菜α-糖苷酶抑制剂(3S,4R)-6-乙酰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基(Z)-2-甲基丁-2-烯酸酯的全合成和绝对构型测定
标题:苋菜α-糖苷酶抑制剂(3S,4R)-6-乙酰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基(Z)-2-甲基丁-2-烯酸酯的全合成和绝对构型测定
摘要:在此,我们报道了α-糖苷酶抑制剂(3 R,4 S)-6-乙酰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基(Z)-2-甲基丁-2-烯酸酯的首次全合成:及其对映体.我们的合成证实了 Navarro-Vazquez 和 Mata置于dft 计算的基础上分别提出的色烷结构.此外,我们的合成使我们能够确定天然化合物的绝对构型为 (3 S,4 R) 而不是 (3 R,4 S).
DOI:10.1021/acs.Jnatprod.3C00236

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专利信息


专利号:US-2023357257-A1
优先权日:2020-12-28
标 题 :Novel process for the synthesis of noroxymorphone from morphine
发明人：GORBACHEV DMITRY; LAM HON WAI; SAXENA AAKARSH; SAXENA NAVIN SATYAPAL
权利人:NAVIN SAXENA RESEARCH & TECH PVT LTD
摘要:The present invention relates to a novel, efficient, pot- and atom-economical, and industrially applicable process for converting morphine to noroxymorphone using reagents and solvents of lesser toxicity and lower cost with respect to those used in the prior art.

专利号:US-9676698-B2
优先权日:2010-07-20
标 题:Method of producing ingenol-3-angelate
发明人：HOGBERG THOMAS; GRUE-SORENSEN GUNNAR; LIANG XIFU; HORNEMAN ANNE MARIE; PETERSEN ANDERS KLARSKOV
权利人:LEO LABORATORIES LTD
摘要:The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). n n n n n n n n n n Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.

专利号:EP-4267583-A1
优先权日:2020-12-28
标题 :Novel process for the synthesis of noroxymorphone from morphine

专利号:WO-2022144911-A1
优先权日:2020-12-28
标 题 :Novel process for the synthesis of noroxymorphone from morphine

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主要参考文献

参考标题:Total Synthesis Of Natural Derivatives And Artificial Analogs Of 13-Oxyingenol And Their Biological Evaluation
作者:Takayuki Ohyoshi,Yuki Tamura,Ichiro Hayakawa,Go Hirai,Yamato Miyazawa,Shota Funakubo,Mikiko Sodeoka,Hideo Kigoshi
摘要:Methodology For The 13-Oxyingenol Natural Derivative (13-Oxyingenol-13-Dodecanoate-20-Hexanoate), Featuring A Ring-Closing Olefin Metathesis Reaction For The "Direct" Construction Of A Highly Strained Inside-Outside Framework And A Mislow-Evans-Type [2,3]-Sigmatropic Rearrangement For The Stereoselective Introduction Of The Hydroxy Group At C5. We Also Synthesized Artificial Analogs Of 13-Oxyingenol And Ingenol

合成参考文献


参考文献:10.1055/s-0032-1317415
摘要:Liang X, Grue-Sørensen G, Petersen A, Högberg T. Semisynthesis of Ingenol 3-Angelate (PEP005): Efficient Stereoconservative Angeloylation of Alcohols. Synlett. 2012 Oct 18;23(18):2647–52. doi: 10.1055/s-0032-1317415.
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