CAS: 89951-56-4; 5-Amino-2Chlorobenzylalcohol

该化合物是有机合成中的一种多用途中间体,其特点是与氯化苯环相连的氨基和羟基功能组,该化合物在制药和农用化学应用中特别宝贵,作为合成更复杂的分子的关键构件.氨基和氢氧基组的存在可以进一步发挥作用,从而能够生产有定制特性的衍生物.其氯化芳香环可增强替代反应的回动性,使其在精细的化学制造中成为有用的前体.该化合物通常在受控制的条件下处理,因为其反应性质确保下游应用的稳定性和纯度.

英文名称5-Amino-2Chlorobenzylalcohol
中文名称(5-氨基-2-氯苯基)甲醇
IUPAC名称(5-amino-2-chlorophenyl)methanol
其它别名5-氨基-2-氯苯甲醇; 5-Amino-2-Chlorobenzyl Alcohol
CAS编号89951-56-4
MFCD编号:MFCD05664329
EINECS号:685-077-4
分子式:C7H8ClNO
分子量:157.6
产品CID: 1929780
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;
InChIKey: LURSRRLUCSSCHJ-UHFFFAOYSA-N
InChI=1S/C7H8ClNO/c8-7-2-1-6(9)3-5(7)4-10/h1-3,10H,4,9H2…
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

6361-21-3 = 89951-56-4
反应条件:1.1 Reagents: Sodium Borohydride Catalysts: Palladium Solvents: Water; 7 Min,Reflux
标题:Chemoselective Reduction Of Nitroarenes,N-Acetylation Of Arylamines,And One-Pot Reductive Acetylation Of Nitroarenes Using Carbon-Supported Palladium Catalytic System In Water
作者:Zeynizadeh,Behzad; Mohammad Aminzadeh,Farkhondeh; Mousavi,Hossein
参考文献:Research On Chemical Intermediates 日期:2021 卷标:47(8) 页码:3289-3312]

1321-74-0 + 89951-56-4 = 89951-56-4
反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 4 H,40 - 45 °C1.2 Reagents: Ammonium Chloride Solvents: Water; 40 - 45 °C1.3 Reagents: Boron Trifluoride Etherate,Tert-Butyl Nitrite Solvents: Tetrahydrofuran; 5 Min,Rt; 60 Min,Rt
标题:The Structural Influence In The Stability Of Polymer-Bound Diazonium Salts
作者:Brase,Stefan; Dahmen,Stefan; Popescu,Crisan; Schroen,Maarten; Wortmann,Franz-Josef
参考文献:Chemistry - A European Journal 日期:2004 卷标:10(21) 页码:5285-5296]

80866-80-4 = 89951-56-4
反应条件:1.1 Reagents: Iron,Hydrochloric Acid Solvents: Ethanol,Water; 3 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 10
标题:Synthesis,Antimalarial Activity,And Preclinical Pharmacology Of A Novel Series Of 4'-Fluoro And 4'-Chloro Analogues Of Amodiaquine. Identification Of A Suitable "Back-Up" Compound For N-Tert-Butyl Isoquine
作者:O'Neill,Paul M.; Shone,Alison E.; Stanford,Deborah; Nixon,Gemma; Asadollahy,Eghbaleh; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(7) 页码:1828-1844]

80866-80-4 = 89951-56-4
反应条件:1.1 Reagents: Iron Solvents: Acetic Acid; 3 H,70 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 7
标题:New Hits As Antagonists Of Gpr103 Identified By Hts
作者:Nordqvist,Anneli; Kristensson,Lisbeth; Johansson,Kjell E.; Isaksson Da Silva,Krystle; Fex,Tomas; Et Al
参考文献:Acs Medicinal Chemistry Letters 日期:2014 卷标:5(5) 页码:527-532]

80866-80-4 = 89951-56-4
反应条件:1.1 Reagents: Iron Solvents: Ethanol,Water
标题:Synthesis Of Antileukemic 2-[2-(Indol-2-Yl)Vinyl]-1-Benzofuran And -Benzo[b]Thiophenes
作者:Dann,Otto; Char,Helmut; Fleischmann,Paul; Fricke,Helmut
参考文献:Liebigs Annalen Der Chemie 日期:1986 卷标:(3) 页码:438-55

2-氯-5-硝基苯甲醛置于7% W/w Pd/c,Sodium Tetrahydroborate,水体系中,用水作为反应溶剂,化学反应 0.23H,以85%的收率获得产物5-氨基-2-氯苄基醇
参考文献:碳载钯催化体系在水中对硝基芳烃的化学选择性还原,芳基胺的n-乙酰化以及硝基芳烃的一锅还原乙酰化
标题:碳载钯催化体系在水中对硝基芳烃的化学选择性还原,芳基胺的n-乙酰化以及硝基芳烃的一锅还原乙酰化
摘要:在水溶剂中使用化学工业喜爱的非均相可回收催化体系开发和/或修饰基本化学反应非常重要.在本文中,我们开发了便捷,绿色和有效的方法,用于在可回收的非均相碳负载钯(pd / C)存在的情况下,对硝基芳烃进行化学选择性还原,芳胺的n-乙酰化以及对硝基芳烃的一锅还原乙酰化.水中的催化系统.利用简单,有效和可回收的催化剂,以及使用水作为完全绿色的溶剂,以及相对较短的反应时间和所需产物的非常好至优异的产率,是所提出的合成方案的一些显着特征. 图形摘要
DOI:10.1007/s11164-021-04469-9

海关参考信息

2902300000-甲苯
2903919090-氯苯
2905110000-甲醇
2906210000-苄醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.