CAS: 848821-58-9; (S)-2-[diphenyl(Trimethylsilanyloxy)Methyl]Pyrrolidine

上下游产品

CAS号22348-32-9 (r)-(+)-α,α-二苯基脯氨醇 | CAS号27607-77-8 三氟甲磺酸三甲基硅酯 | CAS号75-77-4 三甲基氯硅烷 | CAS号22348-31-8 (R)-(+)-2-(二苯甲基)吡咯烷 | CAS号18156-74-6 三甲基硅咪唑(TSIM) | CAS号77581-28-3 (S)-1-ethyl 2-m... | CAS号147-85-3 脯氨酸 | CAS号122-78-1 2-苯基乙醛

(S)-Proline-N-Ethyl Carbamate Methyl Ester置于三乙胺体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 16.0H,反应生成 (2S)-2-[二苯基[(三甲基硅酯)氧基]甲基]-吡咯烷
参考文献:Chiral Aminophosphines As Catalysts For Enantioselective Double-Michael Indoline Syntheses
标题:Chiral Aminophosphines As Catalysts For Enantioselective Double-Michael Indoline Syntheses
摘要:双膦催化的二核亲核试剂对缺电子乙炔的双michael加成反应是合成多种含氮杂环的高效过程.由于反应生成的杂环至少含有一个立体中心,如能开发出该反应的不对称变体,双michael反应将更加有用.氨基膦也可促进双michael反应,而天然及合成中手性胺更易获得;因此,本研究中我们制备了几种新型手性氨基膦.在甲苯磺酰胺基苯基丙二酸酯与3-丁炔-2-酮的不对称双michael反应中,手性氨基膦以非常好产率制得吲哚啉,并具有中等程度的手性诱导作用.
DOI:10.3390/molecules17055626

专利信息

专利号:US-10899773-B2
优先权日:2014-12-19
标 题 :Total synthesis of trioxacarcin DC-45-A2 and preparation of trioxacarcin analogs
发明人：NICOLAOU KYRIACOS C; CAI QUAN
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of trioxacarin analogs of the formula (I) wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.

专利号:WO-2010144293-A1
优先权日:2009-06-08
标 题 :Synthesis of telcagepant and intermediates thereof
发明人：XU FENG; DESMOND RICHARD; HOERRNER R SCOTT; HUMPHREY GUY R; ITOH TETSUJI; JOURNET MICHEL; YOSHIKAWA NAOKI; ZACUTO MICHAEL J
权利人:MERCK SHARP & DOHME; XU FENG; DESMOND RICHARD; HOERRNER R SCOTT; HUMPHREY GUY R; ITOH TETSUJI; JOURNET MICHEL; YOSHIKAWA NAOKI; ZACUTO MICHAEL J
摘要:Disclosed is an efficient synthesis for the manufacture of the caprolactam intermediate (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one: Formula and salts thereof, and an efficient preparation of telcagepant using the caprolactam intermediate.

专利号:US-7820858-B2
优先权日:2006-03-25
标 题 :Concise β2-amino acid synthesis via organocatalytic aminomethylation
发明人：CHI YONGGUI; GELLMAN SAMUEL H; POMERANTZ WILLIAM C; HORNE WILLIAM S; GUO LI; ENGLISH EMILY P
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention provides a method for the synthesis of β 2 -amino acids. The method also provides methods yielding α-substituted β-amino aldehydes and β-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of β 2 -amino acids.

专利号:US-9593071-B2
优先权日:2011-11-22
标题 :Process for the preparation of gamma amino acids and intermediates used in said process
发明人：ADAMO MAURO
权利人:ROYAL COLLEGE SURGEONS IRELAND
摘要:The invention relates to the preparation of gamma amino acids of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof, and to intermediates used for their preparation. (formula I) wherein R 1 is selected from an alkyl group, an alkenyl group, an alkynyl group and a cycloalkyl group, each of which may be optionally substituted and * denotes a chiral center. In particular, the present invention provides an efficient synthesis of (S)-pregabalin which is suitable for carrying out on an industrial scale.

专利号:US-8338620-B2
优先权日:2007-04-03
标 题:Methods for the production of C-8 lactam lactone compounds
发明人：SEDELMEIER GOTTFRIED
权利人:SEDELMEIER GOTTFRIED; NOVARTIS AG
摘要:The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren, the invention relates to a process for the manufacture of a compound of the formula I, n nor a salt thereof, wherein R1 as well as Act are as defined in the specification, and processes of manufacturing this compound as well as intermediates in this process.

专利号:US-2007276142-A1
优先权日:2004-02-19
标题 :Catalytic Asymmetric Synthesis of Optically Active Alpha-Halo-Carbonyl Compounds