CAS: 82671-03-2; Ethyl 2,6-Dichloro-5-Fluoropyridine-3-Carboxylate

该化合物是一种氟丙烯衍生物,广泛用作制药和农用化学合成的关键中间体,其结构为反应性氯和氟替代物,为生物活性化合物的开发提供选择性功能;酯类增强溶解性,便利进一步的衍生;该化合物因其稳定性,高纯度和与交叉反应的兼容性而得到重视,使其适合建造复杂的环环环框架;其应用包括除草剂,真菌杀菌剂和活性药物成分的合成;严格的质量控制确保研究和工业规模生产的一致性.

英文名称Ethyl 2,6-Dichloro-5-Fluoropyridine-3-Carboxylate
中文名称2,6-二氯-5-氟烟酸乙酯
IUPAC名称ethyl 2,6-dichloro-5-fluoronicotinate
其它别名2,6-二氯-5-氟吡啶-3-羧酸乙酯; Ethyl 2,6-Dichloro-5-Fluoropyridine-3-Carboxylate
CAS编号82671-03-2
MFCD编号:MFCD09757511
分子式:C8H6Cl2FNO2
分子量:238.04
产品CID: 1816868
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: FPPLCOWQBGOFDU-UHFFFAOYSA-N
InChI=1S/C8H6Cl2FNO2/c1-2-14-8(13)4-3-5(11)7(10)12-6(4)9/h3H,2H2,1H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数2.0

相似化合物

82671-06-5 1260758-33-5 139911-30-1

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT

上下游产品

合成工艺路线路线简述

82671-02-1 = 82671-03-2 [标题:Reaction Conditions
标题:1,8-Naphthyridine Derivatives And Their Salts
参考文献:Japan]

109-94-4 + 108-13-4 = 82671-03-2
反应条件:1.1 Reagents: Sodium Ethoxide Solvents: Ethanol1.2 Solvents: Ethanol2.1 Reagents: Phosphorus Pentachloride3.1 Reagents: Sulfuric Acid4.1 Reagents: Boron Trifluoride Etherate
标题:Pyridonecarboxylic Acids As Antibacterial Agents. Viii. An Alternative Synthesis Of Enoxacin Via Fluoronicotinic Acid Derivatives
作者:Miyamoto,Teruyuki; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1987 卷标:35(6) 页码:2280-5]

113237-18-6 = 82671-03-2
反应条件:1.1 Reagents: Phosphorus Trichloride2.1 Reagents: Sulfuric Acid Solvents: Water3.1 Reagents: Thionyl Chloride4.1 Solvents: Dichloromethane; Rt; 3 - 4 H,Rt
标题:Synthesis And Biological Activity Of Fluorine-Substituted Pyridine-Heterocyclic Carboxylate Compounds
作者:Zheng,Hui; Et Al
参考文献:Yingyong Huaxue 日期:2010 卷标:27(2) 页码:164-168]

74011-58-8 = 82671-03-2
反应条件:1.1 Reagents: Sodium Ethoxide,Sodium 3-Ethoxy-2-Fluoro-3-Oxoprop-1-En-1-Olate Solvents: Ethanol2.1 Reagents: Phosphorus Pentachloride3.1 Reagents: Sulfuric Acid4.1 Reagents: Boron Trifluoride Etherate
标题:Pyridonecarboxylic Acids As Antibacterial Agents. Viii. An Alternative Synthesis Of Enoxacin Via Fluoronicotinic Acid Derivatives
作者:Miyamoto,Teruyuki; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1987 卷标:35(6) 页码:2280-5]

109-94-4 + 107-91-5 = 82671-03-2
反应条件:1.1 Reagents: Sodium Methoxide2.1 Reagents: Phosphorus Trichloride3.1 Reagents: Sulfuric Acid Solvents: Water4.1 Reagents: Thionyl Chloride5.1 Solvents: Dichloromethane; Rt; 3 - 4 H,Rt
标题:Synthesis And Biological Activity Of Fluorine-Substituted Pyridine-Heterocyclic Carboxylate Compounds
作者:Zheng,Hui; Et Al
参考文献:Yingyong Huaxue 日期:2010 卷标:27(2) 页码:164-168]

96568-02-4 = 82671-03-2
反应条件:1.1 Solvents: Dichloromethane; Rt; 3 - 4 H,Rt
标题:Synthesis And Biological Activity Of Fluorine-Substituted Pyridine-Heterocyclic Carboxylate Compounds
作者:Zheng,Hui; Et Al
参考文献:Yingyong Huaxue 日期:2010 卷标:27(2) 页码:164-168]

113237-20-0 = 82671-03-2
反应条件:1.1 Reagents: Boron Trifluoride Etherate
标题:Pyridonecarboxylic Acids As Antibacterial Agents. Viii. An Alternative Synthesis Of Enoxacin Via Fluoronicotinic Acid Derivatives
作者:Miyamoto,Teruyuki; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1987 卷标:35(6) 页码:2280-5]

75993-41-8 = 82671-03-2 [标题:Reaction Conditions
标题:1,8-Naphthyridine Derivatives And Their Salts
参考文献:Japan]

75993-41-8 = 82671-03-2
反应条件:1.1 Reagents: Phosphorus Pentachloride2.1 Reagents: Sulfuric Acid3.1 Reagents: Boron Trifluoride Etherate
标题:Pyridonecarboxylic Acids As Antibacterial Agents. Viii. An Alternative Synthesis Of Enoxacin Via Fluoronicotinic Acid Derivatives
作者:Miyamoto,Teruyuki; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1987 卷标:35(6) 页码:2280-5]

82671-02-1 = 82671-03-2
反应条件:1.1 Reagents: Sulfuric Acid2.1 Reagents: Boron Trifluoride Etherate
标题:Pyridonecarboxylic Acids As Antibacterial Agents. Viii. An Alternative Synthesis Of Enoxacin Via Fluoronicotinic Acid Derivatives
作者:Miyamoto,Teruyuki; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1987 卷标:35(6) 页码:2280-5]

82671-02-1 = 82671-03-2
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Water2.1 Reagents: Thionyl Chloride3.1 Solvents: Dichloromethane; Rt; 3 - 4 H,Rt
标题:Synthesis And Biological Activity Of Fluorine-Substituted Pyridine-Heterocyclic Carboxylate Compounds
作者:Zheng,Hui; Et Al
参考文献:Yingyong Huaxue 日期:2010 卷标:27(2) 页码:164-168]

82671-06-5 = 82671-03-2
反应条件:1.1 Reagents: Thionyl Chloride2.1 Solvents: Dichloromethane; Rt; 3 - 4 H,Rt
标题:Synthesis And Biological Activity Of Fluorine-Substituted Pyridine-Heterocyclic Carboxylate Compounds
作者:Zheng,Hui; Et Al
参考文献:Yingyong Huaxue 日期:2010 卷标:27(2) 页码:164-168

2,6-二氯-5-氟代烟酰氯以乙醇作为反应溶剂,化学反应 1.25H,以95%的收率获得产物2,6-二氯-5-氟吡啶-3-羧酸乙酯
参考文献:New Pyridine Analogues Ix 519
标题:New Pyridine Analogues Ix 519
摘要:本发明涉及某些新的formula (I)的吡啶类似物,涉及制备这类化合物的方法,它们作为p2Y12抑制剂和抗血栓药物等的用途,它们在心血管疾病中作为药物的使用,以及含有它们的药物组合物.

海关参考信息

2912110000-甲醛
2915110000-甲酸
2933310010-吡啶
2901100000-饱和无环烃
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-10766863-B2
优先权日:2014-11-17
标题 :Monocarboxylate transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT; WU QIONG
权利人:NIROGYONE THERAPEUTICS INC
摘要:The invention generally relates to the field of monocarboxylate transport modulators, e.g., monocarboxylate transport inhibitors, and more particularly to new substituted-quinolone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in treating, modulating, forestalling and/or reducing physiological conditions associated with monocarboxylate transport activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, obesity, diabetes, cardiovascular diseases, tissue and organ transplant rejection, and malaria.