专利号:US-9382288-B2 优先权日:2010-10-06 标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action 发明人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO 权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG 摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).
专利号:WO-2007142222-A1 优先权日:2006-06-09 标 题 :Method for production of pyridoxamine 发明人:SAKAMOTO KEIJI; FUJIMOTO NOBORU; WADA KOUICHI; TSUZAKI KAZUYA 权利人:DAIICHI FINE CHEM CO LTD; SAKAMOTO KEIJI; FUJIMOTO NOBORU; WADA KOUICHI; TSUZAKI KAZUYA 摘要:Disclosed is an effective method for producing pyridoxamine by employing a fermentation technique. Pyridoxamine is one of the substances having a vitamin B6 activity and is useful as a pharmaceutical agent or an intermediate for the synthesis of the pharmaceutical agent. A microorganism strain capable of producing pyridoxamine is now found. Pyridoxamine and/or a salt thereof can be produced in a simple manner and with efficiency by using a cell, a culture, a cell treatment product or the like of the microorganism. The microorganism to be used for the production of pyridoxamine is selected from a bacterium, an yeast and a fungus.
专利号:US-5405772-A 优先权日:1993-06-18 标题 :Medium for long-term proliferation and development of cells 发明人:PONTING IAN L O 权利人:AMGEN INC 摘要:A serum-free or serum-depleted medium for the short- and long-term proliferation and development of cells, particularly hematopoietic cells and bone marrow stromal cells, the medium comprising cell proliferation and development effective amounts of: a standard culture medium such as Iscove's modified Dulbecco's medium; serum albumin; transferrin; a source of lipids and fatty acids; cholesterol; a reducing agent; pyruvate; a glucocorticoid (when the cells to be cultured are hematopoietic cells); nucleosides for synthesis of DNA and RNA; growth factors that stimulate the proliferation and development of stromal cells and cells from a variety of tissues or organs, such as epidermal growth factor, fibroblast growth factor, platelet derived growth factor, and insulin; and extracellular matrix materials, such as collagen, fibronectin, and laminin.
专利号:US-2023266302-A1 优先权日:2020-07-24 标 题:Synthesis and use of n-benzyl sulfonamides 发明人:LAMAR ANGUS A; SHEAFF ROBERT J 权利人:THE UNIV OF TULSA 摘要:Disclosed is a method for preparing N-benzyl sulfonamides. Also disclosed is a composition for treating cancer. The composition includes a N-benzyl sulfonamide and a metabolic inhibitor. Also disclosed is a method for determining the impact on cell ATP levels of a composition containing a N-benzyl sulfonamide with or without a metabolic inhibitor.
专利号:US-7628979-B1 优先权日:2005-04-20 标题 :Use of calco oil blue V in bait formulations for marking and controlling subterranean termites 发明人:MORALES-RAMOS JUAN A; ROJAS MARIA G 权利人:US AGRICULTURE 摘要:Termite bait matrix containing cellulose, calco oil blue V (solvent blue 58 or 9,10-anthracenedione, 1,4-bis[(2-ethylhexyl)amino]), and optionally a termite toxicant (e.g., chitin synthesis inhibitor). Methods of monitoring termite activity in a region involving placing a termite bait matrix in the region and assessing the presence of termites at the site of the termite matrix, the termite bait matrix contains cellulose and 9,10-anthracenedione, 1,4-bis[(2-ethylhexyl)amino]. Methods of killing termites, involving placing a termite bait matrix in a termite habitat and allowing termites to feed on the bait matrix, the termite bait matrix contains cellulose, 9,10-anthracenedione, 1,4-bis[(2-ethylhexyl)amino], and a termite toxicant (e.g., chitin synthesis inhibitor).
专利号:US-2006223147-A1 优先权日:2004-08-05 标题 :Process for producing glycoprotein composition 发明人:NISHIYA HARUE; SATOH MITSUO; MORI KATSUHIRO 权利人:KYOWA HAKKO KOGYO KK 摘要:The present invention relates to a cell into which an RNA capable of suppressing the function of an enzyme catalyzing a reaction which converts GDP-mannose into GDP-4-keto,6-deoxy-GDP-mannose is introduced; a process for producing a glycoprotein using the cell; a cell into which an RNA capable of suppressing the function of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in the complex type N-glycoside-linked sugar chain, and an RNA capable of suppressing the function of an enzyme relating to synthesis of an intracellular sugar nucleotide, GDP-fucose, or an RNA capable of suppressing the function of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body are introduced; a process for producing a glycoprotein composition using the cell; and the like.
1: Crespi AF, Vega D, Sánchez VM, Rodríguez-Castellón E, Lázaro-Martínez JM. Shared Hydrogen Atom Location and Chemical Composition in Picolinic Acid and Pyridoxal Hydrochloride Derivatives Determined by X-ray Crystallography. J Org Chem. 2022 Oct 21;87(20):13427-13438. doi: 10.1021/acs.joc.2c00724. Epub 2022 Sep 8. 232:111816. doi: 10.1016/j.jinorgbio.2022.111816. Epub 2022 Apr 6.
合成参考文献
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