专利号:US-9453037-B2 优先权日:2011-07-28 标 题 :Methylphenidate-prodrugs, processes of making and using the same 发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB 权利人:KEMPHARM INC; KEMPHARM INC 摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
专利号:US-8865854-B2 优先权日:2010-01-07 标 题:Method of synthesizing tuneably high functionality in high molecular weight natural oil polyols 发明人:GARRETT THOMAS M; DU XIAN XIAN 权利人:GARRETT THOMAS M; DU XIAN XIAN 摘要:Methods of one-pot synthesis of high molecular weight natural oil polyols having a functionality of between about 4 and about 8 are provided. The resultant polyols may be directly reacted with polyisocyanates to produce polyurethanes.
专利号:US-9522192-B2 优先权日:2012-12-13 标 题:Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides 发明人:CALIGNANO ANTONIO; D'AGOSTINO GIUSEPPE; LANERI SONIA; MELI ROSARIA; OSTACOLO CARMINE; RUSSO ROBERTO; SACCHI ANTONIA; TRONINO DIANA; DELLA VALLE FRANCESCO; DELLA VALLE MARIA FEDERICA; MARCOLONGO GABRIELE 权利人:EPITECH GROUP SRL 摘要:The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.
专利号:US-2025051183-A1 优先权日:2021-12-13 标题:Lithium metal oxide and a precursor for the synthesis thereof 发明人:KEENE TONY 权利人:UNIV DUBLIN 摘要:The present invention relates to a compound of Formula I, Li(ox)]2[MlmM2nM3k(OH)pFq; wherein M1, M2 and M3 are metals; and X is a halogen chosen from F, Cl and Br; and m, n and k are, independently, a number between 0 and 5, the sum of m, n and k is 5; p and q are, independently, a number between 0 and 8, and the sum of p and q is 8; and to uses thereof and methods of synthesis thereof.
专利号:US-11577963-B2 优先权日:2020-01-17 标 题 :Method of preparing sparsely pillared organic-inorganic hybrid compound 发明人:IHM JISOON; PARK SEOK HWAN 权利人:INNONEP INC 摘要:Provided is a method of preparing a sparsely pillared organic-inorganic hybrid compound. The method of preparing an organic-inorganic hybrid compound includes: preparing a compound having a gibbsite structure by a method other than a hydrothermal synthesis method, using a trivalent metal cation source, an alkali imparting agent, and a first solvent (S10); and preparing an organic-inorganic hybrid compound by a method other than a hydrothermal synthesis method, using the compound of the gibbsite structure, a divalent metal cation source, dicarboxylic acid, and a second solvent (S20).
专利号:EP-3060567-B1 优先权日:2013-10-25 标 题:Method for the synthesis of alkane-1-hydroxy-1,1-diphosphonic acid 发明人:COGELS SAMUEL; NOTTÉ PATRICK PIERRE 权利人:STRAITMARK HOLDING AG
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