CAS: 584-93-0; 2-Bromovalericacid

上下游产品

CAS号109-52-4 正戊酸 | CAS号638-29-9 正戊酰氯 | CAS号616-62-6 2-丙基丙二酸 | CAS号19393-67-0 2-hydroperoxybu... | CAS号107-13-1 丙烯腈 | CAS号41014-93-1 (S)-2-羟基戊酸 | CAS号189103-38-6 3-(2-bromopenta... | CAS号109-52-4 正戊酸 | CAS号818-58-6 3-戊烯酸甲酯 | CAS号760-78-1 DL-正缬氨酸 | CAS号100059-51-6 4-butylsulfonyl... | CAS号19129-92-1 2-溴戊酸甲酯 | CAS号29117-54-2 (S)-1,2-戊二醇 | CAS号94274-78-9 2-iodopentanoic acid | CAS号42768-45-6 2-溴戊酰氯

正戊酸置于三溴化磷,溴体系中,化学反应 6.0H,反应生成 2-溴戊酸
参考文献:银促进的α-溴酰胺的氟化反应
标题:银促进的α-溴酰胺的氟化反应
摘要:据报道,在温和的条件下使用agf可以在α-溴酰胺中形成银促进的cf键形成.这种简单的方法可以访问涉及生物分子支架的叔,仲和伯烷基氟化物.这种转变适用于伯酰胺和仲酰胺,并显示出广泛的官能团耐受性.动力学实验表明,反应速率按3°> 2°> 1°α-碳原子的顺序增加.另外,发现酸性酰胺质子在促进反应中起重要作用.机理研究表明,反应生成叠氮醌中间体,然后对其进行亲核加成以形成具有立体特异性(即保留构型)的cf键.ag I合成位阻醇和醚也得到了证明.给出了α-溴酰胺与o亲核试剂反应的例子.
DOI:10.1002/chem.202004769

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-4410711-A
优先权日:1981-06-29
标题 :Method for the synthesis of lepiochlorin, an antibiotic
发明人：MCMORRIS TREVOR C; DONAUBAUER JOHN R
权利人:UNIV CALIFORNIA
摘要:A method for the synthesis of lepiochlorin, an antibiotic.

专利号:US-5750764-A
优先权日:1995-11-17
标题 :Synthesis and resolution of propionic acid derivatives
发明人：MARAIS STEPHANUS FRANCOIS; KHAILE THEBEEAPELO JOHN; NJAMELA OWEN LUNGILE; BRAITHWAITE DANA HELEN; DAVIDSON DEBORAH NICOLE; JUNGMANN CHRISTA MARIA; PARKINSON CHRISTOPHER JOHN; GARDINER NEIL STOCKENSTROM; STEENKAMP LUCIA HENDRINA; VAN EEDEN SKEIN ETIENNE
权利人:AECI LTD
摘要:A process for the production of disubstituted propionic acid derivatives which are intermediates in the synthesis of α-arylpropionic acids such as naproxen, involves the reaction of a naphthalene derivative such as 2-methoxynaphthalene, with an alkylating agent such as an alkyl pyruvate in the presence of a catalyst, and then dehydrating and hydrogenolising, or directly hydrogenolising, or derivatising and then hydrogenolising the product thereof, to produce the desired compound.

专利号:WO-2009049476-A1
优先权日:2007-09-20
标题 :Process for the manufacture of (+)-biotin
发明人：CHEN FEN-ER; DAI HUI-FANG; HUANG JIAN; XIONG FEI; JING SHU-PING
权利人:DSM IP ASSETS BV; UNIV FUDAN; CHEN FEN-ER; DAI HUI-FANG; HUANG JIAN; XIONG FEI; JING SHU-PING
摘要:Disclosed are processes for preparing synthetic biotin intermediates and a process for preparing biotin using said intermediates. In particular, disclosed is a process for the stereoselective total synthesis of the natural product (+)-biotin of formula (I).

专利号:US-8338621-B2
优先权日:2005-12-21
标题:Process for the preparation of 2-oxo-1-pyrrolidine derivatives
发明人：SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY
权利人:SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY; UCB SA
摘要:The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I) n n n n n n n n n n Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.

专利号:WO-8911473-A1
优先权日:1988-05-27
标 题:Process for the synthesis of o-substituted oxime compounds
发明人：CHEMPOLIL THOMAS MATHEW
权利人:ALLIED SIGNAL INC
摘要:A novel process for the production of O-substituted oximes is disclosed. The process involves reacting an oxime with an alkali-metal hydroxide optionally in a solvent which forms an azeotrope with water to form a mixture of the alkali metal salt of the oxime and water, removing all or a portion of the water by distilling the mixture azeotropically and reacting the distilled mixture with an alpha halo carboxylic acid.