CAS: 5789-24-2; 5-((1H-Indol-3-yl)Methyl)-3-Phenyl-2-Thioxoimidazolidin-4-One

该化合物是一种基本氨基酸,是Treptophan的衍生物,其特征是,存在一个附属于hydantoin结构的苯硫磷组,这是一个由五人组成的环,内含两个碳基组和两个氮原子,将苯硫酸结合成一个五人环,可增强它的活性和溶性,使其在各种生物化学应用中,特别是在Peptide合成和氨基硫酸分析中有用.Phenylthiohydantoin衍生物经常用于Edman蛋白降解法中蛋白质排序方法,因为它们有助于确定聚苯丙胺酸,该化合物一般是白色到非白固体的,在有机溶剂中溶解,其稳定性和再活性可能受诸如pH和温度等环境因素的影响,这些环境因素是实验室环境中的重要考虑因素.总体而言,苯基锡丁-DL-tryptopphhan是生物化学和分析化学领域的宝贵工具.

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CAS号103-72-0 异硫氰酸苯酯 | CAS号54-12-6 色氨酸

合成工艺路线路线简述

    📜Dl-色氨酸,硫代异氰酸苯酯置于吡啶,Sodium Hydroxide体系中,化学反应生成 苯基硫代乙内酰脲-色氨酸
    参考文献:Among The Missing: Content On Lesbian And Gay People In Social Work Journals
    标题:Among The Missing: Content On Lesbian And Gay People In Social Work Journals
    摘要:在社会工作文献中,关于同性恋和同性恋者的问题几乎没有被提及.本研究考察了1988年至1997年间在四本主要社会工作期刊上发表的关于同性恋的文章内容.文章根据关注点被编码为hiv/aids与同性恋社区或其他与女同性恋者和男同性恋者有关的问题.文章还被编码为以客户为中心,以工作者为中心或宏观为中心.在77篇关于同性恋的文章中,三分之二集中于hiv/aids.大多数文章反映了对同性恋者的以问题为导向的观点;很少有文章涉及异性恋主义或环境干预.需要更多关注同性恋者和女同性恋者优势,异性恋主义条件及社会公正的文献.
    DOI:10.1093/sw/47.4.345

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    专利信息


    专利号:US-6090250-A
    优先权日:1993-09-20
    标题 :Chiral surfactants and methods for their use in chiral separations
    发明人:MAZZEO JEFFREY R; GROVER EDWARD R; SWARTZ MICHAEL E; MERION MICHAEL; PETERSEN JOHN S
    权利人:WATERS INVESTMENTS LTD
    摘要:PCT No. PCT/US94/10655 Sec. 371 Date Mar. 20, 1996 Sec. 102(e) Date Mar. 20, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08529 PCT Pub. Date Mar. 30, 1995Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using nucellar capillary electrophoresis is disclosed. A chiral surfactant having the general formula: is described, R1 is the hydrophobic tail, Y-A-X is the linker, the brackets define a chiral center, and the hydrophilic head group is Z. All the various components may potentiate the enantioselectivity of the chiral surfactant. The capillary electrophoresis (CE) system includes a narrow diameter capillary, a high voltage power supply, an electrolyte reservoir at each end of the capillary, a means for injecting a sample, and a detector. Chiral surfactants are dissolved in the electrolyte above their critical micelle concentration (cmc), resulting in the formation of chiral micelles. The electrolyte reservoirs and capillary tube are filled with the electrolyte. A sample containing a mixture of enantiomers is then injected into the capillary, and a high voltage potential is applied across the capillary. The sample components migrate through the capillary due to the influence of the applied electric field. An example separation of the four sereoisomers of aspartame is shown.

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    合成参考文献


    参考文献:10.1007/s00216-002-1622-2
    摘要:Steiner WE, Clowers BH, Hill HH. Rapid separation of phenylthiohydantoin amino acids: ambient pressure ion-mobility mass spectrometry (IMMS). Analytical and Bioanalytical Chemistry. 2002 Oct 31;375(1):99–102. doi: 10.1007/s00216-002-1622-2.
    参考文献:10.1007/s00216-012-6514-5
    摘要:Del Bubba M, Checchini L, Lepri L. Thin-layer chromatography enantioseparations on chiral stationary phases: a review. Analytical and Bioanalytical Chemistry. 2012 Nov 17;405(2-3):533–54. doi: 10.1007/s00216-012-6514-5.
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