CAS: 534-64-5; Pyrithiamine (Hydrobromide)

该化合物是一种四铵化合物,其特性是其结构,其中包括一个,其中包括一个义.这种化合物通常具有溶性等特性,因为其具有离子性质,可溶于水和极地有机溶剂.它经常用于生物化学和制药用途,特别是用作试剂或药物配制,因为它能够与生物系统相互作用.氨基和氢氧功能组的存在表明氢联结的潜力,影响其再活性和与其他分子的相互作用.此外,该化合物的结构可能赋予特定的生物活动,使其对医药化学具有兴趣.应当参考安全数据,以便处理和使用,因为四硝基铵化合物可能具有不同程度的毒性和环境影响.

结构式图片

相似化合物

24328-74-3 24361-62-4 86045-97-8

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2-(2-methylpyridin-3-yl)ethanol 4-Amino-2-methyl-5-bromomethylpyrimidine dihydrobromide

合成工艺路线路线简述

    📜5-溴甲基-2-甲基-4-氨基嘧啶溴化氢,3-(2-羟基乙基)-Alpha-皮考啉 反应生成 新吡啶硫胺
    参考文献:Synthesis And Properties Of Neopyrithiamine Salts
    标题:Synthesis And Properties Of Neopyrithiamine Salts
    摘要:
    DOI:10.1021/ja01174A086

    海关参考信息

    专利信息


    专利号:WO-2024235233-A1
    优先权日:2023-05-15
    标 题:Bio-based trans-aconitate, preparation method therefor and use thereof
    发明人：LV XUEFENG; WANG QINGGANG; HUANG XUENIAN; PENG XIN; HOU HONGBIN; GUO QIANG; WANG MIN; LI JIBIN; GU MENG; DU ZHIQIANG; WU MAOCHENG; Geng ce; Si Xuejian; XU GUANGQIANG; GUO JIAN; ZHANG YUNPENG; YIN JIJIN; GUO QING
    权利人:QINGDAO INST BIOENERGY & BIOPROCESS TECH CAS; SHANDONG LUKANG PHARMACEUTICAL CO LTD
    摘要:The present invention relates to the technical field of synthetic biology, and provides bio-based trans-aconitate, a preparation method therefor and a use thereof. On one hand, the present invention provides a trans-aconitic acid recombinant engineered bacterium, and the transformed engineered bacterium can significantly improve the capability of fermentation production of trans-aconitic acid. Further provided is a fermentation process of liquid submerged fermentation for producing trans-aconitic acid, and the yield of the trans-aconitic acid is further improved by means of the proper time of low-dissolved oxygen control and a sugar supplementing process. Also provided is a process for synthesizing high-purity aconitate from trans-aconitic acid products prepared by fermentation, the problem of removing pigment impurities from aconitic acid raw materials of the fermentation product is solved, and the specific use and product of the aconitate in industrial production are provided. The present invention provides a complete system of strain transformation, fermentation production, product synthesis and use, provides a complete technical route for bio-based trans-aconitic acid and an industrial use thereof, and has huge economic value and application prospect.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Derek J Mattern, Et Al. Identification Of The Antiphagocytic Trypacidin Gene Cluster In The Human-Pathogenic Fungus Aspergillus Fumigatus. Appl Microbiol Biotechnol. 2015 Dec;99(23):10151-61.
    [参考文献]: Gaganpreet S Tiwana, Et Al. Identification Of Vitamin B1 Metabolism As A Tumor-Specific Radiosensitizing Pathway Using A High-Throughput Colony Formation Screen. Oncotarget. 2015 Mar 20;6(8):5978-89.
    [参考文献]: Lindsey C Vedder, Et Al. Interactions Between Chronic Ethanol Consumption And Thiamine Deficiency On Neural Plasticity, Spatial Memory, And Cognitive Flexibility. Alcohol Clin Exp Res. 2015 Nov;39(11):2143-53.
    [参考文献]: S A Chornyy, Et Al. Comparative Characteristic Of Thiamine Antagonists On Apoptosis Induction In Different Types Of Nerve Cell Lines. Ukr Biokhim Zh (1999). 2008 Sep-Oct;80(5):76-84.
    [参考文献]: Sergiy Chornyy, Et Al. Thiamine Deficiency Caused By Thiamine Antagonists Triggers Upregulation Of Apoptosis Inducing Factor Gene Expression And Leads To Caspase 3-Mediated Apoptosis In Neuronally Differentiated Rat Pc-12 Cells. Acta Biochim Pol. 2007;54(2):315-22.

    合成参考文献


    参考文献:10.1093/jn/110.5.937
    摘要:Pekkanen L. Effects of Thiamin Deprivation and Antagonism on Voluntary Ethanol Intake in Rats. The Journal of Nutrition. 1980 May;110(5):937–44. doi: 10.1093/jn/110.5.937.
    摘要:DE CARO L, RINDI G, PERRI V, FERRARI G. [Vitamin B1 deficiency induced by dietary means and by vitamin antagonists (neopyrithiamine and oxythiamine) in rodents]. Int Z Vitaminforsch Beih. 1958;28(3):252–73.
    摘要:FERRARI V. Changes in tissue free aminoacids in thiamine-deficient or pyrithiamine-treated rats. Acta Vitaminol. 1958 Aug;12(4):145–50.
    摘要:DE CARO L, RINDI G, FERRARI G. Cocarboxylase content of tissues of mice treated with pyrithiamine or oxythiamine. Int Z Vitaminforsch Beih. 1958;29(1-2):40–5.
    参考文献:10.1037//0735-7044.106.4.634|10.1037/0735-7044.106.4.634
    摘要:Mair RG, Lacourse DM. Radio-frequency lesions of the thalamus produce delayed-nonmatching-to-sample impairments comparable to pyrithiamine-induced encephalopathy in rats. Behav Neurosci. 1992 Aug;106(4):634–45. doi: 10.1037//0735-7044.106.4.634.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知