CAS: 4654-39-1; 2-(4-Bromophenyl)Ethanol

上下游产品

oxirane (4-bromophenyl)magnesium bromide (+/-)-2-(4-bromophenyl)oxirane 2-(4'-aminophenyl)ethyl alcohol 1-bromo-4-(2-bromoethyl)benzene 1-bromo-4-(2-chloroethyl)benzene 4-(2-((tert-butyldimethylsilyl)oxy)ethyl)benzoic acid phenyl-carbamic acid-(4-bromo-phenethyl ester)

4-溴苯乙酸甲酯置于三乙基硼氢化钠,Sodium Hydroxide体系中,用 乙醚,甲苯,甲醇 作为反应溶剂,化学反应 10.0H,以85%的收率获得产物4-溴苯乙醇
参考文献:一般实用的三乙基硼烷催化的羰基官能团还原为醇
标题:一般实用的三乙基硼烷催化的羰基官能团还原为醇
摘要:大量廉价的三乙基硼烷与烷醇钠的组合可反应生成一种高效催化剂,用于在温和条件下使用廉价的氢化硅烷将酯以及酮和醛还原为醇.该催化剂体系表现出优异的化学选择性和高水平的官能团耐受性.机理研究表明,三乙基烷氧基棉酸钠的静置状态是bet 3与醇钠反应的产物.该硼酸盐物质与氢硅烷反应形成nabet 3 H,这会迅速还原酯.
DOI:10.1002/chem.201502942

专利信息

专利号:US-5075450-A
优先权日:1990-06-28
标 题 :Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes
发明人：RASMUSSON GARY H; TOLMAN RICHARD L; PATEL GOOL F
权利人:MERCK & CO INC
摘要:New intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes, of the formula: ##STR1## wherein R 2 is 2-thiopyridyl, and n R 3 is C 2 -C 4 alkoxycarbonyl, C 1 -C 4 , or trifluoromethylsulfonyloxy. The above compounds are useful intermediates in producing testosterone 5α-reductase inhibitors which are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:WO-2012152438-A1
优先权日:2011-05-11
标题 :Process for the preparation of nitrate acid ester of organic compounds
发明人：BONFANTI ANNALISA; STORONI LAURA; RONSIN GAEL
权利人:NICOX SA; BONFANTI ANNALISA; STORONI LAURA; RONSIN GAEL
摘要:The present invention relates to a one-step process for the synthesis of nitric acid esters or 15 N isotopically labeled nitrate esters of organic compounds starting from the correspondent alcohols. Formula (I).

专利号:WO-2023122754-A1
优先权日:2021-12-23
标 题 :Processes and intermediates for preparing gb13, gb22 and himgaline
发明人：LANDWEHR ELEANOR; SHENVI RYAN; BAKER MEGHAN; OGUMA TAKUYA
权利人:SCRIPPS RESEARCH INST
摘要:Provided herein are processes for the streamlined synthesis of Galbulimima alkaloids, such as himbadine, isolated from Galbulimima belgraveana and G. baccatta, trees endemic to the rainforests of Northern Australia and Papua New Guinea, as well as analogs thereof, such as GB13, GB16, GB22, and himgaline, and further including intermediates useful in the synthesis of these and related compounds.

专利号:US-8513465-B2
优先权日:2008-02-04
标题:Potassium organotrifluoroborate derivative and a production method therefor
发明人：KANG HEONJOONG; HAM JUNGYEOB; AHN HONG RYUL; PARK YOUNG HEE
权利人:KANG HEONJOONG; HAM JUNGYEOB; AHN HONG RYUL; PARK YOUNG HEE; SNU R&DB FOUNDATION
摘要:Provided are a production method for a potassium organotrifluoroborate compound having a hydroxyl group, and a novel potassium organotrifluoroborate compound having a hydroxyl group. The production method is advantageous in that a potassium organotrifluoroborate compound can be produced in a single reaction without recourse to a process of isolating and purifying an intermediate. The novel potassium organotrifluoroborate compound having a hydroxyl group is useful as a reactant which is widely used in the total synthesis of physiologically active natural products and diverse organic synthesis reactions including halogen substitution reactions, 1,2- and 1,4-addition reactions using a rhodium (Rh) catalyst, and Suzuki coupling reactions using a palladium (Pd) catalyst.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.