CAS: 383-53-9; 2-Bromo-1-[4-(Trifluoromethyl)Phenyl]Ethan-1-One

上下游产品

1-(4-trifluoromethylphenyl)ethanone ethylene glycol methanol 1-(bromoethynyl)-4-(trifluoromethyl)benzene N-(4-trifluoromethyl-phenacyl)-phthalimideN-(4-trifluoromethyl-phenacyl)-phthalimide cyclopropylaminN-4-Trifluormethylphenacylcyclopropylamin 6-(2-Methoxy-phenoxy)-2-(4-trifluoromethyl-phenyl)-imidazo[1,2-b]pyridazin-3-ol 5-Trifluoromethyl-1-[4-(4-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester

对三氟甲基苯乙烯置于1,3-二溴-5,5-二甲基海因,水体系中,化学反应 3.0H,反应生成2-溴-4'-(三氟甲基)苯乙酮
参考文献:1,3-二溴-5,5-二甲基乙内酰脲介导的末端烯烃在水中的氧化酰胺化
标题:1,3-二溴-5,5-二甲基乙内酰脲介导的末端烯烃在水中的氧化酰胺化
摘要:通过用1,3-二溴-5,5-二甲基乙内酰脲处理,然后与分子碘和hcl水溶液反应,将多种末端烯烃在水中以25-86%的收率转化为相应的酰胺.一锅中加入nh 3(或胺).这种无金属和有机溶剂的方案不仅适用于苯乙烯衍生物,而且首次在末端脂族烯烃上效果很好.
Doi:10.1039/c7Ob02329D

专利信息

专利号:US-8906915-B2
优先权日:2009-12-17
标 题:Compounds, compositions, and methods for controlling biofilms
发明人：DE KEERSMAECKER SIGRID; DE VOS DIRK; ERMOLATEV DENIS; STEENACKERS HANS; VAN DER EYCKEN ERIK; VANDERLEYDEN JOZEF; SAVALIYA BHARAT S
权利人:DE KEERSMAECKER SIGRID; DE VOS DIRK; ERMOLATEV DENIS; STEENACKERS HANS; VAN DER EYCKEN ERIK; VANDERLEYDEN JOZEF; SAVALIYA BHARAT S; UNIV LEUVEN KATH
摘要:The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent, and to substituted 2-aminoimidazoles wherein the amino group bears a terminal heterocyclic group such as a triazolyl group which are formed through azide-alkyne Huisgen cycloaddition starting from said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to a class of N-(azidoalkyl)pyrimidin-2-amines useful as starting materials for the synthesis of said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to antimicrobial compositions that include a microbial biofilm formation inhibiting amount of such substituted 2-aminoimidazoles or imidazo[1,2-a]pyrimidinium salts in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.

专利号:US-11325903-B2
优先权日:2016-11-30
标 题:Substituted pyrazole compounds and methods of using them for treatment of hyperproliferative diseases
发明人：SIDDIQUI M ARSHAD; CIBLAT STEPHANE; DERY MARTIN; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; BRUNEAU-LATOUR NICOLAS; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW J; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae (Ia), (Ib), (Ic), (Id) and (Ie), in which R 1 , L 1 , L 2 , Q, L 3 , R 3 , L 4 , R 4 , L 5 , and R 5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

专利号:US-8691854-B2
优先权日:2005-07-01
标题:Chemical compounds and the uses thereof as a medicine
发明人：CHAIMBAULT CORINNE; DROUOT CYRILLE; JAMOT LAURE; PRUSS REBECCA; SIMON CELINE
权利人:CHAIMBAULT CORINNE; DROUOT CYRILLE; JAMOT LAURE; PRUSS REBECCA; SIMON CELINE; TROPHOS
摘要:The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated. n Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products. n The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.

专利号:US-4968702-A
优先权日:1989-01-17
标 题 :Substituted quinolinecarboxylic acids
发明人：POLETTO JOHN F; POWELL DENNIS W; BOSCHELLI DIANE H
权利人:AMERICAN CYANAMID CO
摘要:Substituted quinolinecarboxylic acids useful in the treatment of arthritis by inhibiting the progressive joint deterioration characteristic of arthritic disease and for inducing immunosuppression are disclosed. Methods of synthesis and use of the novel compounds are also disclosed.

专利号:CN-103450177-A
优先权日:2012-05-29
标题 :Synthesis and preparation method of a class of metronidazole grafted thiazole hydrazone derivatives

专利号:CN-101735800-B
优先权日:2007-10-17
标 题 :A class of organic electron transport and/or hole blocking material and its synthesis method and application