CAS: 3734-33-6; N-Benzyl-2-((2,6-Dimethylphenyl)Amino)-N,N-Diethyl-2-Oxoethanaminium Benzoate

Denatonium Hydroxide,苯甲酸置于丙酮体系中,用 丙酮 作为反应溶剂,化学反应 3.0H,以105 Gram Of Denatonium Benzoate Was Obtained的收率获得产物苯甲地那铵
参考文献:Preparation Of A Quaternary Ammonium Hydroxide And Use Thereof For The Preparation Of A Quaternary Ammonium Salt
标题:Preparation Of A Quaternary Ammonium Hydroxide And Use Thereof For The Preparation Of A Quaternary Ammonium Salt
摘要:本发明涉及一种制备季铵羟化物的工艺,特别是去甲头孢铵羟化物,以及其用于制备季铵盐,特别是去甲头孢苯甲酸盐或去甲头孢脂肪酸衍生物的用途.由于其极苦的味道,后一种化合物在艺术上被用作嫌恶剂,杀菌剂,防污剂和调味剂.通常,它是从有机环境中的季铵卤化物制备而来,经过分离和纯化后,转化为一种吸湿不稳定的羟化物中间体,然后立即在其制备的溶剂中转化为所需的盐.现在发现,这些分离步骤可以通过在水性条件下进行反应来避免.这更为简单,不需要昂贵的预防措施来避免处理时的接触.此外,本发明的工艺允许从利多卡因化合物中以大部分水为主的一锅法合成季铵盐.

专利信息

专利号:US-12129222-B2
优先权日:2016-08-11
标题:Production of bitter principle derivatives
发明人：WYRWA RALF; RODE CLAUDIA; SEEMANN THOMAS; MEINEL LORENZ; RITZER JENNIFER; SCHNABELRAUCH MATTHIAS
权利人:UNIV WUERZBURG J MAXIMILIANS; JULIUS MAXIMILIANS UNIV
摘要:It is an object of the present invention to introduce carboxylic acid-functionalities suitable for coupling into the denatonium structure by means of simple synthesis, namely the synthesis of bitter principle derivatives based on the denatonium structure according to formula 1:For example, according to the invention, lidocaine derivatives may be reacted with carboxylated benzyl halogenides. The carboxylated denatonium derivatives of the present invention are especially applied in medicine, biology, medical engineering as well as cosmetics, the pharmaceutical, chemical, and foodstuff industry.

专利号:US-2022356497-A1
优先权日:2019-06-26
标 题 :Compositions and methods for synthesis of terpenoids
发明人：DE KOK STEFAN; LAU WARREN; MCSORLEY FERN; MEYER HERMANN-JOSEF; SERBER ZACH; WAWRZYN GRAYSON
权利人:ZYMERGEN INC
摘要:The disclosure relates to the biosynthesis of terpenoids, such as, for example, geraniol and derivatives thereof, using genetic engineering. In particular, the disclosure relates to the biosynthesis of nepetalactol, nepetalactone, dihydronepetalactone, and derivatives thereof. The disclosure provides recombinant cells genetically engineered to produce high levels of nepetalactol, nepetalactone and/or dihydronepetalactone. The disclosure also provides methods of producing nepetalactol, nepetalactone and dihydronepetalactone using cell-based systems as well as cell-free systems.

专利号:US-10737239-B2
优先权日:2015-11-27
标题 :Ultrafast high space-time-yield synthesis of metal-organic frameworks
发明人：BURCKHART JULIA; MARX STEFAN; ARNOLD LENA; HOFMANN CLAUS; Müller Ulrich
权利人:BASF SE
摘要:The invention relates to a process for the preparation of metal-organic frameworks (MOFs) in form of a homogenous powder, and a process wherein the metal-organic framework is molded into shaped bodies.

专利号:US-11708320-B2
优先权日:2018-06-29
标 题:Environmentally-friendly hydroazidation of olefins
发明人：XU HAO
权利人:UNIV GEORGIA STATE RES FOUND
摘要:The present invention provides processes for the synthesis of organic azides, intermediates for the production thereof, and compositions related thereto.

专利号:US-9487471-B1
优先权日:2014-04-14
标题 :Synthesis of pyrethroids and pyrethroid-containing compositions
发明人：COELHO PEDRO; MEINHOLD PETER; CHEN MIKE M Y
权利人:PROVIVI INC
摘要:The present invention provides methods for synthesizing pyrethroid compounds. The methods include forming a first reaction comprising an olefin and an allethrolone-type unsaturated alcohol under conditions sufficient to form a metathesis product and converting the metathesis product to the pyrethroid. Methods of the invention can be used to prepare compounds including pyrethrin I, cinerin I, jasmolin I, pyrethrin II, cinerin II, and jasmolin II as well as other synthetic pyrethroid compounds. Insecticidal compositions and methods for controlling insects are also described.

专利号:US-2024379227-A1
优先权日:2023-05-09
标题:Construction of nearest neighbor structures for graph machine learning technologies
发明人：ERRICA FEDERICO
权利人:NEC Laboratories Europe GmbH
摘要:A method for construction of nearest neighbor structures includes determining a set of cross-class neighborhood similarities based on a set of distributions of data obtained by applying a model to data present in a dataset. The method selects a first cross-class neighborhood similarity from the set of cross-class neighborhood similarities based on one or more inter-class cross-class neighborhood similarities and one or more intra-class cross-class neighborhood similarities, and builds a nearest neighbor graph based on the first cross-class neighborhood similarity. The present invention can be used in a variety of applications including, but not limited to, several anticipated use cases in drug development, material synthesis, and medical/healthcare.