CAS: 3697-24-3; 5-Methylchrysene

该化合物是一种多环芳烃,其特点是结构复杂,由多个引信芳香环组成,来源于铬,其甲基组附于丙烯框架的第五位置,该化合物一般没有色素,在室温第5位上不见黄色固体,以其疏水性闻名,使其在水中不易溶,但在有机溶剂中可溶. 5-甲基丙烯对环境化学很感兴趣,因为它存在于化石燃料和燃烧产品中,而且已经研究过其潜在的致癌特性.作为五氯苯大家庭的成员,该化合物可以在特定条件下发生各种化学反应,包括氧化和光降解.其分子结构有助于其稳定性和持久性,引起人们对其对人类健康和生态系统的影响的关切.由于其潜在的毒性和环境影响,适当的处理和处置是必不可少的.

结构式图片

相似化合物

1705-85-7 218-01-9 3351-28-8

物理性质

MSDS等安全信息

欧盟法规

[ECHA物质

上下游产品

屈-5-甲醛 Chrysene-5-Carboxaldehyde 87901-88-0
5-羟基甲基屈 5-Hydroxymethyl-Chrysen 67411-86-3

合成工艺路线路线简述

    📜苯并[a]菲置于trityl Tetrafluoroborate体系中,化学反应生成 5-甲基-1,2-苯并菲
    参考文献:Metal-Ammonia Reduction. Xi. Regiospecific And Stereoselective Reduction In The Chrysene Series
    标题:Metal-Ammonia Reduction. Xi. Regiospecific And Stereoselective Reduction In The Chrysene Series
    摘要:
    DOI:10.1021/jo00821A009

    海关参考信息

    专利信息


    专利号:US-2003162992-A1
    优先权日:2001-12-14
    标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
    发明人：WATANABE KYOICHI A; DU JINFA
    摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

    专利号:CA-2470202-A1
    优先权日:2001-12-14
    标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides

    专利号:WO-03051298-A2
    优先权日:2001-12-14
    标 题:Preparation of intermediates useful in the synthesis of antiviral nucleosides

    专利号:EP-1461041-A4
    优先权日:2001-12-14
    标 题:PREPARATION OF INTERMEDIATES SUITABLE FOR THE SYNTHESIS OF ANTIVIRAL NUCLEOSIDES

    专利号:EP-1461041-A2
    优先权日:2001-12-14
    标 题:Preparation of intermediates useful in the synthesis of antiviral nucleosides

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    主要参考文献

    [参考文献]: A A Toropov, Et Al. Qspr Modeling Of Octanol/water Partition Coefficient For Vitamins By Optimal Descriptors Calculated With Smiles. Eur J Med Chem. 2008 Apr;43(4):714-40.
    [参考文献]: C E Afshar, Et Al. Bay-Region Distortions In A Methanol Adduct Of A Bay-Region Diol Epoxide Of The Carcinogen 5-Methylchrysene. Carcinogenesis. 1996 Nov;17(11):2507-11.
    [参考文献]: Christoph Hutzler, Et Al. Analysis Of Carcinogenic Polycyclic Aromatic Hydrocarbons In Complex Environmental Mixtures By Lc-Appi-Ms/ms. Anal Chim Acta. 2011 Sep 30;702(2):218-24.
    [参考文献]: G H Shiue, Et Al. Comparative Metabolism And Dna Binding Of 6-Nitro-5-Methylchrysene And 5-Methylchrysene. Carcinogenesis. 1987 Sep;8(9):1327-31.
    [参考文献]: Garrett A Kaas, Et Al. Tet1 Controls Cns 5-Methylcytosine Hydroxylation, Active Dna Demethylation, Gene Transcription, And Memory Formation. Neuron. 2013 Sep 18;79(6):1086-93.

    合成参考文献


    摘要:Fazio T, Howard JW; pp. 461-505 in Handbook of Polycyclic Aromatic Hydrocarbons. Bjorseth A, ed. New York, NY: Marcel-Dekker Inc. (1983)
    摘要:
    摘要:American Conference of Governmental Industrial Hygienists TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. Cincinnati, OH 2016, p. 118
    摘要:Cerilliant (a Sigma-Aldrich company); Safety Data Sheet for 5-Methylchrysene. Product Number: SCM-028, Version 3.5 (Revision Date 06/04/2016). Available from, as of March 2, 2017:
    摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
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