CAS: 324757-50-8; Thieno[3,2-C]Pyridine-5(4H)-Acetic Acid, α-(2-Chlorophenyl)-6,7-Dihydro-, (αr)-
该化合物是合成氯皮甲酯的关键中间体,一种用于预防血栓事件的抗塑剂.这种有机碳苯乙酸衍生物对于确保最后活性药物成分的立体化学纯度至关重要.其高抗原纯度和一贯质量使制药厂更愿意选择生产具有最佳功效和安全特征的氯皮甲甲酸.该化合物在受管制条件下合成,以达到严格的监管标准,确保遵守药典要求.其稳定性和定义明确的化学特性有利于高效下游加工,使其成为大规模丙基乙醇生产的可靠建筑块.
- 英文名称Thieno[3,2-C]Pyridine-5(4H)-Acetic Acid, α-(2-Chlorophenyl)-6,7-Dihydro-, (αr)-
- 中文名称R-氯吡格雷羧酸
- IUPAC名称(R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid
- 其它别名R-Clopidogrel Carboxylic Acid; (R)-A-(2-Chlorophenyl)-6,7-Dihydrothieno[3,2-C]Pyridine-5(4H)-Aceticacid; (R)-α-(2-Chlorophenyl)-6,7-Dihydrothieno[3,2-C]Pyridine-5(4H)-Acetic Acid; Clopidogrel Acid R-Isomer; Thieno[3,2-C]Pyridine-5(4H)-Acetic Acid, α-(2-Chlorophenyl)-6,7-Dihydro-, (αr)-; Clopidogrel Ep Impurity A (R-Isomer) ((R)-Clopidogrel Carboxylic Acid); (R)-2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-C]Pyridin-5(4H)-yl)Acetic Acid (Clopidogrel Impurity）; (R)-2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-C]Pyridin-5(4H)-yl)Acetic Acid
- CAS编号324757-50-8
- FDA UNII编号:N8GXZ27ZHW
- 分子式:C15H14ClNO2S分子量:307.8
- 产品CID: 1315750
- 产品分类有机原料 → 羧酸类化合物及衍生物
物理性质
上下游产品
CAS号90055-55-3 氯吡格雷杂质A | CAS号118-10-5 辛可宁合成工艺路线路线简述
📜氯吡格雷杂质a,辛可宁 以 乙醇,丙酮 用作溶剂,化学反应 18.0H,以84%的收率获得(1S)-Quinolin-4-Yl((2R,4S,5R)-5-Vinylquinuclidin-2-yl)Methanol (S)-2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-C]Pyridin-5(4H)-yl)Acetate
参考文献:Wo2008/18779
标题:Wo2008/18779
海关参考信息
- 2902600000-乙苯
2903919090-氯苯
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2004074215-A1
优先权日:2003-02-03
标 题 :Process for preparation of clopidogrel, its salts and pharmaceutical compositions
发明人：NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI
权利人:NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI
摘要:The invention discloses an improved process for racemization of methyl (R)Â(-) alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate , a stereoisomer formed in the synthesis of clopidogrel i.e. methyl (S)-(+)-alpha (2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate or its salts. The invention is also for an improved process for production of clopidogrel or its pharmaceutically acceptable salts. The invention further discloses novel clopidogrel salts and pharmaceutical compositions comprising them.
专利号:US-7153969-B2
优先权日:1997-10-06
标 题:Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates
发明人：BOUSQUET ANDRE; MUSOLINO ANDREE
权利人:SANOFI AVENTIS
摘要:Methyl (R)-2-(R 1 OSO 2 )-2-(2-chlorophenyl)acetates useful as intermediates in the preparation of methyl (S)-2(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)acetate.
