CAS: 25422-31-5; (2S,5S,17S,20S,26S,29S,35S,41S,44S)-44-((S)-2-Aminopropanamido)-26-Benzyl-17,35-Bis(2-Carboxyethyl)-29-(Carboxymethyl)-2-(3-((Diaminomethylene)Amino)Propyl)-41-(Hydroxymethyl)-23-Isobutyl-5-Isopropyl-20-Methyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43-Tetradecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42-Tetradecaazahexatetracontanedioic Acid

专利信息

专利号:US-7345117-B1
优先权日:1998-02-25
标题:Sulphated hyaluronic acid and sulphated derivatives thereof covalently bound to polyurethanes, and the process for their preparation
发明人：BARBUCCI ROLANDO; CONSUMI MARCO; MAGNANI AGNESE; CALLEGARO LANFRANCO
权利人:BARBUCCI ROLANDO; CONSUMI MARCO; MAGNANI AGNESE; CALLEGARO LANFRANCO
摘要:The present invention relates to the synthesis of a haemocompatible polymer, consisting of a polyurethane bound covalently to sulphated hyaluronic acid. These sulfated derivatives have anticoagulative, non-thrombogenic, antiviral and anti-inflammatory properties. They also have the ability to inhibit platelet adhesion, aggregation and activation. The invention is particularly advantageous in resisting the enzyme hyaluronidase, therefore ensuring anti-coagulant activities for longer periods of time when compared to similar compounds. This biocompatible polymer material is well suited for surgical or other medicinal uses.

专利号:US-5814460-A
优先权日:1990-02-14
标题:Method for generating and screening useful peptides
发明人：VENTON DUANE L; HOPFINGER ANTON J; LEBRETON GUY
权利人:DIATIDE INC
摘要:PCT No. PCT/US93/08231 Sec. 371 Date Feb. 21, 1995 Sec. 102(e) Date Feb. 21, 1995 PCT Filed Aug. 9, 1993 PCT Pub. No. WO94/04558 PCT Pub. Date Mar. 3, 1994The invention allows the generation and screening of a large population of peptides for the presence of peptides which bind a particular macromolecule or macromolecular complex with high affinity, and further allows the favored net synthesis of analyzable quantities of such peptides, by using is the 'trap' a macromolecule or macromolecular complex for which binding of the peptide is desired. The starting mixture is preferably spiked with a peptide having some affinity for the target macromolecule so that mutation of the spike or 'lead' peptide is favored. The development of improved binding peptides through scrambling may be dynamically monitored by initially binding the target with an insolubilized ligand, and then looking for an increase in the concentration of the target in the soluble phase as a result of the displacement of the reference ligand by scrambled peptides.

专利号:US-5885781-A
优先权日:1995-06-07
标题:Regulation of cytokine synthesis and release
发明人：JOHNSON KIRK; CREASEY ABLA A; AARDEN LUCIEN A
权利人:CHIRON CORP; RED CROSS BLOOD TRANSF SERV NL
摘要:Methods of treatment and prevention of diseases associated with release ofeutrophil elastase and IL-8 by administration of TFPI, and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI and the ultimate determination of patient prognosis are also disclosed.

专利号:EP-0831893-B1
优先权日:1995-06-07
标题:Regulation of neutrophil elastase synthesis and release
发明人：JOHNSON KIRK; CREASEY ALBA A; AARDEN LUCIEN A
权利人:CHIRON CORP
摘要:Methods of treatment and prevention of diseases associated with release of neutrophil elastase and IL-8 by administration of TFPI, and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI and the ultimate determination of patient prognosis are also disclosed.

专利号:US-5366862-A
优先权日:1990-02-14
标题 :Method for generating and screening useful peptides
发明人：VENTON DUANE L; HOPFINGER ANTON J; LE BRETON GUY
权利人:RECEPTOR LAB INC
摘要:The invention allows the generation and screening of a large population of peptides for the presence of peptides which bind a particular macromolecule or macromolecular complex with high affinity, and further allows the favored net synthesis of analyzable quantities of such peptides, by using as the 'trap' a macromolecule or macromolecular complex for which binding of the peptide is desired. The starting mixture is preferably spiked with a peptide having some affinity for the target macromolecule so that mutation of the spike or 'lead' peptide is favored. The development of improved binding peptides through scrambling may be dynamically monitored by initially binding the target with an insolubilized ligand, and then looking for an increase in the concentration of the target in the soluble phase as a result of the displacement of the reference ligand by scrambled peptides.

专利号:CN-101705240-A
优先权日:2009-07-23
标 题 :Synthesis of batroxobin gene and preparation method of expression product thereof