CAS: 215454-72-1; Thieno[2,3-C]Pyridin-7-Amine

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2306278-28-2 2920401-04-1 1326715-27-8

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pyridine 6-oxidethieno2,3-cpyridine 6-oxide p-toluenesulfonyl chloride

合成工艺路线路线简述

    📜Thieno<2,3-C>Pyridine 6-Oxide,对甲苯磺酰氯,Ammonium Hydroxide置于ice,水,Magnesium Sulfate,Silica Gel体系中,用 氯仿 用作溶剂,化学反应 17.5H,以to Give 2.8 G Of The Title Compound As A Brown Oily Material的收率获得噻吩并[2,3-C]吡啶-7-胺
    参考文献:Fused Imidazo[1,2-A]Pyridines
    标题:Fused Imidazo[1,2-A]Pyridines
    摘要:提供了化学式为##str1##的化合物,这些化合物可用作抗溃疡剂.

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    专利信息


    专利号:WO-2014035829-A1
    优先权日:2012-08-31
    标题:Substituted 3-aminothieno[2,3-c]pyridine-2-carboxamide analogs as positive allosteric modulators
    发明人:LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; POSLUSNEY MICHAEL S; BRIDGES THOMAS M; Daniels john s
    权利人:UNIV VANDERBILT
    摘要:In one aspect, the invention relates to substituted 3-aminothieno[2,3-c]pyridine-2- carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

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