CAS: 214360-46-0; 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Benzonitrile

该化合物是一种碳酸酯衍生物,通常用作有机合成的多用途中间体,特别是在铃木-宫浦交叉相交反应中. 酸酯组比免费的磷酸形式增强稳定性,改进处理和储存. 苯环上的环状环状环状环形替代体为进一步功能化提供了额外的回动性,使其在制药和材料科学应用中具有价值. 它的高纯度和一贯性能确保催化转化的可靠结果. 该化合物通常作为晶状固体供应,具有精细的特性,便于合成工作流程中精确的异测测量控制.

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CAS号6952-59-6 间溴苯甲腈 | CAS号25015-63-8 频那醇硼烷 | CAS号73183-34-3 双戊酰二硼 | CAS号1048647-68-2 3-(苯甲氨基羰基)苯硼酸频哪酯 | CAS号766-84-7 3-氯苯腈 | CAS号2237-30-1 3-氨基苯甲腈 | CAS号253342-48-2 3-甲基苯硼酸频呐醇酯 | CAS号450412-21-2 3-溴-2-碘苯甲腈 | CAS号403-54-3 3-氟苯甲腈 | CAS号154197-00-9 3-(4-methoxyphe... | CAS号89900-92-5 3-氰基-[1,1-联苯]-4-羧酸甲酯

合成工艺路线路线简述

    📜3-(苯甲氨基羰基)苯硼酸频哪酯置于bromotriphenoxyphosphonium Bromide,三乙胺体系中,用 氯仿 用作溶剂,以60%的收率获得3-氰基苯硼酸频哪醇酯
    参考文献:使用亚磷酸三苯酯-卤素试剂通过 Von Braun 降解酰胺温和合成腈
    标题:使用亚磷酸三苯酯-卤素试剂通过 Von Braun 降解酰胺温和合成腈
    摘要:公开了合成芳香族和脂肪族腈的温和程序.在溴化三苯氧基鏻 (Tpbpr 2 ) 的存在下,N-烷基和 N,N-二烷基酰胺在有史以来报道的最温和条件下以非常好到极好的收率经历冯布劳恩降解成腈.该反应通过在-60 oc 下形成亚氨酰溴中间体进行,随后在氯仿中或什至在室温下回流时脱烷基化.在 N-叔丁基,N-α-苯乙基和 N-二苯甲基酰胺的情况下,在-30 oc 下生成的氯三苯氧基氯化鏻 (Tpccl 2 ) 也是有效的.
    Doi:10.1055/s-2007-1072591

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    专利信息


    专利号:US-2025101045-A1
    优先权日:2022-01-18
    标题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives
    发明人：DAS BHASKAR
    权利人:LONG ISLAND UNIV
    摘要:The present disclosure is concerned with borylated amidoximes useful in the synthesis of biologically relevant drug-like molecules, including functionalized oxadizole and quinazolinone derivatives. Also disclosed are methods of making borylated amidoximes, methods of making functionalized oxadiazole and quinazolinone compounds using the amidoximes, and functionalized oxadiazole and quinazolinone compounds prepared from borylated amidoximes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    专利号:WO-2023141114-A2
    优先权日:2022-01-18
    标 题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives

    专利号:AU-2023208727-A1
    优先权日:2022-01-18
    标题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives

    专利号:EP-4466275-A2
    优先权日:2022-01-18
    标 题 :Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives

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    合成参考文献


    摘要:Kitanosono, T.; Kobayashi, S., Science of Synthesis: Advances in Organoboron Chemistry towards Organic Synthesis, (2019) 1, 303.
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