CAS: 21402-26-6; 4-Bromo-3-Chloroaniline

该化合物是含有分子式C6H5BrClN的卤化活性衍生物.该化合物是有机合成,特别是生产药品,农用化学品和染料的多用途中间体.其独特的替代模式(分别是4和3个位置的溴和氯组)使选择性的功能化变得有用,因此对于构建复杂的芳香框架很有价值.该产品在标准条件下表现出高纯度和稳定性,确保了混合反应的可靠性能,如Buchwald-Hartwig 喷射或Suzuki-Miyaura交叉组合.其定义明确的再活动特征和与各种反应条件的兼容性使得研究人员在精细的化学和材料科学应用中成为首选选择.

英文名称4-Bromo-3-Chloroaniline
中文名称4-溴-3-氯苯胺
IUPAC名称4-bromo-3-chloroaniline
其它别名4-Bromo-3-Chloro Aniline; 4-Bromo-3-Chloroaniline, Pestanal(R), Analytical Standard; 4-Bromo-3-Chloroaniline; (E)-4-Methoxy-4'-Nitrostilbene; 4-Bromo-3-C
CAS编号21402-26-6
MFCD编号:MFCD00041311
EINECS号:244-370-3
FDA UNII编号:2GTM4SW4OH
分子式:C6H5BrClN
分子量:206.47
产品CID: 1113418
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: QLYHPNUFNZJXOQ-UHFFFAOYSA-N
InChI=1S/C6H5BrClN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS09;
注释: Exclamation mark & Environment
危险类别急性毒性类别4(经口)
水生慢性毒性类别2
急性毒性类别4(吸入)
急性毒性类别4(经皮)
特定目标器官毒性-重复接触类别2
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H302 |吞咽有害.
H411 |对水生生物有毒并具有长期持续影响.
H332 |吸入有害.
H312 |皮肤接触有害.
H373 |长期或反复接触可能损害器官.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P280-P302+P352
危险等级6.1
UN编号2811.0
危险品标志Xi,T,Xn
风险等级Harmful
包装等级Ⅲ
安全声明28-36/37-36/37/39-26-23
危险类别码20/21/22-33-36/37/38-22
WGK Germany3

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

3-氯苯胺置于氢溴酸,氧气,2-Methylpyridinium Nitrate体系中,用水用作溶剂,化学反应 8.0H,以77%的收率获得4-溴-3-氯苯胺
参考文献:使用可重复使用的离子液体 2-甲基吡啶鎓对苯胺和芳基酮进行无金属有氧氧化溴化
标题:使用可重复使用的离子液体 2-甲基吡啶鎓对苯胺和芳基酮进行无金属有氧氧化溴化
摘要:以氢溴酸为溴源,分子氧为氧化剂,在水中由可回收的2-甲基吡啶鎓硝酸盐离子液体催化苯胺和芳基酮的有氧氧化溴化.该催化体系显示出非常好的效率和原子经济性.
Doi:10.1177/1747519819895978

海关参考信息

2903919090-氯苯
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-4264775-A
优先权日:1976-10-27
标题:Synthesis of Î²-aminostyrenes
发明人：WHITE WILLIAM A
权利人:LILLY CO ELI
摘要:A simple process for the preparation of beta -aminostyrenes proceeds from anilines by successively diazotizing, reacting with a vinyl ester, and reacting with a secondary amine without purification of the intermediate products. The compounds are reactive enamines useful in organic synthesis.

专利号:US-8853410-B2
优先权日:2009-04-30
标题:Process for preparing substituted isoxazoline compounds and their precursors
发明人：RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN
权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE
摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.

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优先权日:2000-12-29
标题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides

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优先权日:2014-02-21
标题 :5-BENZYLISOQUINOLINE DERIVATIVE COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, PROCESS FOR THE SYNTHESIS OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

专利号:US-2003004189-A1
优先权日:2000-12-29
标题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides

专利号:US-2010063105-A1
优先权日:2000-12-29
标题 :Pharmaceutical uses and synthesis of nicotinanilide-n-oxides