CAS: 20518-17-6; 1-(P-Tolyl)-1H-Pyrazole

相似化合物

25699-83-6 99662-34-7 1126-00-7

上下游产品

CAS号288-13-1 吡唑 | CAS号624-31-7 对碘甲苯 | CAS号106-38-7 对溴甲苯 | CAS号5720-05-8 对甲基苯基硼酸 | CAS号3076-56-0 Triacetic acid ... | CAS号102-52-3 1,1,3,3-四甲氧基丙烷 | CAS号539-44-6 对甲基苯肼 | CAS号337957-59-2 1-(4-甲基苯基)吡唑-4-甲醛

📜对苄基三氟甲磺酸置于potassium Phosphate,2-二叔丁基膦-2',4',6'-三异丙基-3,6-二甲氧基-1,1'-联苯,Potassium Hydroxide,Bis(Dibenzylideneacetone)-Palladium(0)体系中,用 1,4-二氧六环,乙醇 用作溶剂,化学反应 36.0H,反应生成1-(对甲苯基)-1H-吡唑
参考文献:钯催化芳烃三氟甲磺酸酯与吡唑衍生物的偶合反应合成n-芳基吡唑
标题:钯催化芳烃三氟甲磺酸酯与吡唑衍生物的偶合反应合成n-芳基吡唑
摘要:描述了通过钯催化的芳基三氟甲磺酸酯与吡唑衍生物的偶合来合成n-芳基吡唑的方法.使用t Bubrettphos作为配体,钯催化的各种芳基三氟甲磺酸酯(包括邻位取代的芳基三氟甲磺酸酯)与吡唑衍生物的c-N偶联有效地进行,以高收率得到n-芳基吡唑产物.发现3-三甲基甲硅烷基吡唑是偶联的极佳吡唑底物,相应的产物1-芳基-3-三甲基甲硅烷基吡唑也可作为合成n-芳基吡唑衍生物的很好模板,如在该区域的区域选择性卤化所证明的那样.吡唑环的3位,4位和5位.
Doi:10.1021/acs.Joc.9B00673

专利信息

专利号:US-9676721-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.

专利号:US-9555039-B2
优先权日:2011-05-09
标题:Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)

专利号:US-2008176857-A1
优先权日:2005-03-25
标题 :4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
权利人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n n n n n n n n n n wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2008194590-A1
优先权日:2005-03-28
标 题:4-Piperazinylthieno [2,3-D] Pyrimidine Compounds as Platelet Aggregation Inhibitors
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , X 2k , R 2l , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-7825149-B2
优先权日:2006-01-19
标 题 :Substituted imidazoles
发明人：CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
权利人:PFIZER LTD
摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

专利号:CN-113046772-B
优先权日:2021-03-18
标题:A kind of electrochemical synthesis method of 4-selenyl pyrazole derivatives