CAS: 1788-10-9; 4-Acetylbenzenesulfonyl Chloride

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CAS号99-92-3 4-氨基苯乙酮 | CAS号3283-79-2 4-acetylbenzene... | CAS号149104-90-5 4-乙酰苯硼酸 | CAS号61827-67-6 4-乙酰基苯磺酸钠盐 | CAS号5038-59-5 4-(2-溴乙酰基)苯磺酰氯 | CAS号200442-61-1 4-乙基磺酰基苯乙酮 | CAS号92-91-1 4-联苯乙酮 | CAS号1565-17-9 4-乙酰基苯磺酰胺 | CAS号37069-08-2 1-[4-(1,3-benzo... | CAS号902137-95-5 1-(4-thiomorpho... | CAS号494189-46-7 4-acetyl-N-(5-m... | CAS号58722-34-2 1-[4-(哌啶-1-磺酰基)... | CAS号60000-87-5 4-乙酰基-N,N-二甲基苯磺酰胺

4-氨基苯乙酮置于cucl2*h2O 盐酸,Sodium Nitrite,二氧化硫体系中,用 水,溶剂黄146 用作溶剂,化学反应 2.0H,以55%的收率获得4-乙酰基苯磺酰氯
参考文献:Simple And Efficient Synthesis Of 3,4-Dihydro-2-Pyridones Via Novel Solid-Supported Aza-Annulation
标题:Simple And Efficient Synthesis Of 3,4-Dihydro-2-Pyridones Via Novel Solid-Supported Aza-Annulation
摘要:A Diverse Array Of 3,4-Dihydro-2-Pyridones 13 Were Produced Utilizing The Unique Properties Of Solid-Supported Reactions To Both Drive The Reactions To Completion And Isolate The Desired Products. The Pyridones Were: Synthesized In High Purity By A Simple Sequence Of Navel Steps Commencing From An Acetophenone-Functionalized Resin. The Para-Substituted Acetophenone 9 Could Be Anchored To The Resin Through Either A Sulfonamide Or A Carboxamide Linkage. The Sulfonamide Resin 9A,Which Gave The Best Results,Was Treated With Several Aryl Aldehydes And Ethoxide To Give A Variety Of Chalcones 10A-K,In Excellent Yield (82-99%) Upon Tfa Cleavage. Addition Of Either Methyl Or Allyl Malonate And Dbu To 10A-K Afforded Smoothly The Michael Adducts 11A-J (70-99%) Which Were Subsequently Cyclized In One Step Employing Acetic Acid As A Catalyst And Several Diverse Amines To Give Pure 3,4-Dihydro-2-Pyridones 13A-P In Moderate To Excellent Yields (30-98%).
Doi:10.1021/jo005609X

专利信息

专利号:WO-2016111658-A1
优先权日:2015-01-07
标 题:Synthesis of thiosemicarbazone derivatives comprising sulphonamide group with potential anticonvulsant activity
发明人：IYIDOGAN AYSEGUL; EMRE EMINE ELCIN; TOPALFAKIOGÄžLU RAHIME BETÃœL; KAYMAKÇIOÄžLU BEDIA; ARICIOÄžLU FEYZA
权利人:IYIDOGAN AYSEGUL; EMRE EMINE ELCIN
摘要:The present invention relates to the synthesis method of thiosemicarbazone derivatives comprising sulphonamide group and having high anticonvulsant/antiepileptic activity.