CAS: 177966-58-4; Fmoc-D-Phe(3,4-Dicl)-Oh
该化合物是一种合成氨基酸衍生物,其特点是存在二氯替代物和氟氧基碳基(Fmoc)保护组;该化合物具有一种D-苯丙氨基脊柱,它是苯丙胺的抗衡剂,有助于其独特的立体化学特性;Fmoc组通常用作氨基功能的合成保护组,允许在不干扰矿山的情况下有选择地作出反应;二氯替代会加剧化合物的疏水性,并可能影响其生物活动,使其对医药化学和peptide设计感兴趣;此外,氟苯乙烯组提供稳定性,并可促进净化过程;
- 英文名称Fmoc-D-Phe(3,4-Dicl)-Oh
- 中文名称Fmoc-D-3,4-二氯苯丙氨酸
- IUPAC名称(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3,4-dichlorophenyl)propanoic acid
- 其它别名FM°C-D-Phe(3,4-Cl2)-OH; FM°C-3,4-dichloro-D-phenylalanine; FM°C-D-Phe(3,4-DiCl)-OH; Fluorenylmethoxycarbonyl-D-3,4-dichlorophenylalanine
- CAS编号177966-58-4
- MFCD编号:MFCD00273472
- 分子式:C24H19Cl2NO4分子量:456.33
- 产品CID: 906770
- 产品分类有机原料→生命科学→氨基酸及其衍生物→苯丙氨酸及其衍生物
- 相似结构搜索
- InChIKey: QNVHCYWPXIGFGN-JOCHJYFZSA-N
- QNVHCYWPXIGFGN-J°CHJYFZSA-N
- 计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数6.0
相似化合物
177966-59-5 80741-39-5 114873-13-1物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2912110000-甲醛
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专利信息
专利号:US-8598089-B2
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
专利号:US-2007042401-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries
专利号:US-2012245040-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries
专利号:US-2009062147-A1
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
专利号:US-7972994-B2
优先权日:2003-12-17
标 题 :Methods for synthesis of encoded libraries
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主要参考文献
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-945.
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