CAS: 120-43-4; Ethyl Piperazine-1-Carboxylate

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57260-70-5 57260-71-6 31166-44-6

上下游产品

CAS号59325-12-1 ethyl 4-benzylp... | CAS号86366-60-1 bis-cyanomethyl... | CAS号110-85-0 哌嗪 | CAS号541-41-3 氯甲酸乙酯 | CAS号19213-72-0 1-乙氧甲酰咪唑 | CAS号142-64-3 哌嗪二盐酸盐单水合物 | CAS号205432-12-8 JS-K | CAS号55513-17-2 1-(3,4-二氯苄基)哌嗪 | CAS号37478-58-3 2-(哌嗪-1-基)乙酸 | CAS号4318-42-7 N-异丙基哌嗪 | CAS号398137-19-4 1-(四氢吡喃-4-基)哌嗪 | CAS号5321-48-2 1-(3-甲基苯甲基)哌嗪 | CAS号141403-43-2 N-(2-丙炔)-哌嗪-N-羧酸乙酯 | CAS号20503-89-3 4-(4,5-Diphenyl... | CAS号19553-02-7 1-Piperazinecar... | CAS号189251-55-6 ethyl 4-phenacy... | CAS号21867-64-1 正丙基哌嗪

4-[(Z)-(2,4-二硝基苯氧基)-氧偶氮基]-1-哌嗪羧酸乙酯置于谷胱甘肽,Glutathione S-Transferase P1-1体系中,化学反应生成N-哌嗪甲酸乙酯
参考文献:Synthesis,Mechanistic Studies,And Anti-Proliferative Activity Of Glutathione/glutathione S-Transferase-Activated Nitric Oxide Prodrugs
标题:Synthesis,Mechanistic Studies,And Anti-Proliferative Activity Of Glutathione/glutathione S-Transferase-Activated Nitric Oxide Prodrugs
摘要:Nitric Oxide (No) Prodrugs Such As O-2-(2,4-Dinitrophenyl) 1-[(4-Ethoxycarbonyl)Piperazin-1-Yl]Diazen-1-Ium-1,2-Diolate (Js-K) Are A Growing Class Of Promising No-Based Therapeutics. Nitric Oxide Release From The Anti-Cancer Lead Compound,Js-K,Is Proposed To occur Through A Nucleophilic Aromatic Substitution By Glutathione (Gsh) Catalyzed By Glutathione S-Transferase (Gst) To Form A Diazeniumdiolate Anion That Spontaneously Releases No. In This Study,A Number Of Structural Analogues Of Js-K Were Synthesized And Their Chemical And Biological Properties Were Compared With Those Of Js-K. The Homopiperazine Analogue Of Js-K Showed Anti-Cancer Activity That Is Comparable With That Of Js-K But With A Diminished Reactivity Towards Both Gsh And Gsh/gst; Both The Aforementioned Compounds Displayed No Cytotoxic Activity Towards Normal Renal Epithelial Cell Line At Concentrations Where They Significantly Diminished The Proliferation Of A Panel Of Renal Cancer Cell Lines. These Properties May Prove Advantageous In The Further Development Of This Class Of Nitric Oxide Prodrugs As Cancer Therapeutic Agents. Published By Elsevier Ltd.
Doi:10.1016/j.Bmc.2008.09.063

专利信息

专利号:US-9458111-B2
优先权日:2010-07-29
标题:Process for the synthesis of substituted urea compounds
发明人：LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS
权利人:LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS; BIAL—PORTELA & CA S A
摘要:A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof: n nthe process comprising the reaction of a carbamate of Formula (II′): Formula (I′):n n nwith a primary or secondary amine of the formula R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.

专利号:US-2005019747-A1
优先权日:2002-08-07
标 题 :Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
发明人：ANDERSON DANIEL G; LEVENBERG SHULAMIT; LANGER ROBERT S
摘要:A method of screening cell-polymer interactions. The method includes depositing monomers as a plurality of discrete elements on a substrate, causing the deposited monomers to polymerize, thereby creating an array of discrete polymer elements on the substrate, incubating the substrate in a cell-containing culture medium, and characterizing a predetermined cell behavior on each polymer element.

专利号:WO-2010108584-A1
优先权日:2009-03-26
标题:Synthesis of n-substituted furan-2(5h)-ones
发明人：IGNATYEV NIKOLAI MYKOLA; ZLOTIN SERGEI G; SIMIRSKAYA NINA I
权利人:MERCK PATENT GMBH; IGNATYEV NIKOLAI MYKOLA; ZLOTIN SERGEI G; SIMIRSKAYA NINA I
摘要:The present invention relates to a process for preparing N-substituted furan-2(5H)-ones where the reaction medium comprises at least one Ionic Liquid, to the use of Ionic Liquids for preparing furan-2(5H)-ones, and to compounds preparable by the aforementioned process.

专利号:WO-2015173779-A1
优先权日:2014-05-16
标题:Process for the preparation of teneligliptin and its novel intermediates
发明人：DUBEY SUSHIL KUMAR; KUMAR NEERAJ; NARWAL SURESH; DUBEY SHAILENDRA KUMAR; KUMAR PRAMOD
权利人:MICRO LABS LTD
摘要:The present invention relates to a novel process for the preparation of Teneligliptin or its pharmaceutically acceptable salts and its hydrates thereof. The invention also relates to novel intermediates used in the synthesis of Teneligliptin and their preparation.

专利号:US-4678784-A
优先权日:1984-04-11
标题 :Method for the treatment of LHRH diseases and conditions
发明人：HO CHIH Y
权利人:MCNEILAB INC
摘要:Fused tetracyclic benzodiazepines of the formula (I): (I) where R1 is a cyclic amine such as 1-piperazine and R2 is H or a substituent as defined herein are useful as LHRH antagonizing agents. Also, methods for their synthesis, intermediates used in such synthesis, methods for use as medicaments and pharmaceutical compositions are described.

专利号:CA-2539670-A1
优先权日:2003-09-15
标 题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof