CAS: 99-57-0; 2-Amino-4-Nitrophenol

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2,4-二硝基酚置于一水合肼体系中,用 水 作为反应溶剂,以95%的收率获得产物2-氨基-4-硝基苯酚
参考文献:多孔二氧化硅包裹且可磁回收的rh Np:一种高效,稳定且绿色的催化剂,用于催化转移加氢,并在水中"缓慢释放"化学计量的肼
标题:多孔二氧化硅包裹且可磁回收的rh Np:一种高效,稳定且绿色的催化剂,用于催化转移加氢,并在水中"缓慢释放"化学计量的肼
摘要:设计并制备了由多孔二氧化硅包裹的核-壳结构纳米催化剂(fe 3 O 4 @sio 2-Nh 2-Rhnps @ Msio 2),用于催化硝基化合物转化为相应的胺的加氢反应.rh纳米粒子充当活性中心,多孔的二氧化硅壳在氢源肼的"缓慢释放"中起着重要的作用.该反应可以在绿色溶剂水中平稳地进行,并且可以通过将水合肼的用量减少至化学计量的1.5当量的底物来改善原子经济性.显着地,获得了高催化效率,并且周转频率(tof)可以高达4373 H-1在对硝基苯酚(4-Np)的还原中.动力学研究表明,向4-Np的反应顺序为〜0.5,表观活性能e A为58.18 Kj Mol-1,这也证明了高催化效率.另外,已经在15个循环后证实了催化剂的优异稳定性,而没有任何催化活性的损失,并且由于fe 3 O 4核,在反应后易于被磁体回收.
DOI:10.1039/c7Gc00986K

专利信息

专利号:WO-2024151228-A1
优先权日:2023-01-10
标题:Enzymatic dyestuff synthesis
发明人：YAKIN Ä°SMAIL
权利人:SMARTERCHEM KIMYA PROJE VE DANISMANLIK ANONIM SIRKETI
摘要:The invention relates to the enzymatic synthesis of dyestuffs developed to be used for the coloring of fibers, yarns, staples or surfaces obtained by natural or synthetic ways in areas such as textile, paper and leather.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-4082781-A
优先权日:1976-06-04
标题:Synthesis of 2-alkanoylamino-4-nitrophenyl phosphorylcholine-hydroxide
发明人：GAL ANDREW E
权利人:US HEALTH EDUCATION & WELFARE
摘要:A method for synthesizing a 2-alkanoylamino-4-nitrophenyl phosphorylcholine-hydroxide useful as a sphingomyelinase-specific chromogenic artificial substrate in the diagnostic testing for Niemann-Pick disease. The method comprises reacting 2-amino-4-nitrophenol with an alkanoyl halide to form the alkananilide; phosphorylating the alkali phenolate salt of the alkananilide with β-bromoethylphosphoryl dichloride to form a mixture of mono- and di-alkananilide phosphoric acid esters; recovering from the mixture the mono-alkananilide phosphoric acid ester and quaternizing it with trimethylamine; and treating the resulting quaternary salt with a mixture of weak acidic and weak basic ion exchange resins to convert it into the 2-alkanoylamino-4-nitrophenyl phosphoryl-choline-hydroxide.

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-7550510-B2
优先权日:2001-07-06
标 题 :Solid phase synthesis of arylretinamides
发明人：CURLEY JR ROBERT W; MERSHON SERENA M; BARNETT DEREK W; CLAGETT-DAME MARGARET; CHAPMAN JASON S
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.