CAS: 92050-16-3; 5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydronaphthalen-2-Amine

• 英文名称5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydronaphthalen-2-Amine
• 中文名称5,5,8,8-四甲基-5,6,7,8-四氢萘-2-胺
• IUPAC名称5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine
• 其它别名2-氨基-5,5,8,8-四甲基-5,6,7,8-四氢萘; 5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydronaphthalen-2-Ylamine
• CAS编号92050-16-3
• MFCD编号:MFCD12828202
• EINECS号:198-814-5
• 分子式:C14H21N
• 分子量:203.33
• 产品CID: 2455134
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• InChIKey: AMDKYPNODLTUMY-UHFFFAOYSA-N
• InChI=1S/C14H21N/c1-13(2)7-8-14(3,4)12-9-10(15)5-6-11(12)13/h5-6,9H,7-8,15H2,1-4H3…
• 计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

物理性质

• 熔点63-65 °C
• 沸点310.2±31.0 °C at 760 mmHg
• 闪点143.5±20.1 °C
• 密度0.9±0.1 g/cm3
• PSA:26.02
• LogP:3.6178
• 折射率1.524
• 蒸汽压0.0±0.7 mmHg at 25°C
• 储存条件2-8°C, protect from light
• 产品应用该化合物用作治疗急性红外球细胞白血病的抗蛋白酸受体抗激剂抗体抗体激素综合物,

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
• 警示词Warning(警告)
• 危险描述H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

欧盟法规

上下游产品

合成工艺路线路线简述

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  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate; 2 - 5 Bar,70 °C
  标题:Dihydroindene And Tetrahydronaphthalene Compounds For Treating Disease
  参考文献:United States]
  
  102121-55-1 = 92050-16-3
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate; 2 - 5 Bar,70 °C
  标题:Preparation Of Pentamethyltetrahydronaphthalene Derivatives For Use As Human Retinoid X Receptor Modulators
  参考文献:World Intellectual Property Organization]
  
  102121-55-1 = 92050-16-3
  反应条件:1.1 Reagents: Stannous Chloride Solvents: Ethanol; 12 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water
  标题:Selective Alkylation Of βii-Tubulin And Thioredoxin-1 By Structurally Related Subsets Of Aryl Chloroethylureas Leading To Either Anti-Microtubules Or Redox Modulating Agents
  作者:Fortin,Jessica S.; Cote,Marie-France; Lacroix,Jacques; Desjardins,Michel; Petitclerc,Eric; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:2008 卷标:16(15) 页码:7277-7290]
  
  102121-55-1 = 92050-16-3
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate; 24 H,25 °C
  标题:Methods For The Production And Use Of Tricyclic Retinoids
  参考文献:European Patent Organization]
  
  102121-55-1 = 92050-16-3
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Ethanol; 6 H,70 °C
  标题:Synthesis Of Tamibarotene
  作者:Bian,Haiyong; Xu,Wenfang
  参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2009 卷标:40(1) 页码:9-11]
  
  102121-55-1 = 92050-16-3
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 15 H,1 Atm,Rt
  标题:Preparation Of Tetrahydronaphthalenylureidobenzoic Acids As Retinoid Agonists.
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  102121-55-1 = 92050-16-3
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  标题:Methods To Generate An Array Of Novel Rexinoids By Sar On A Potent Retinoid X Receptor Agonist: A Case Study With Net-Tmn
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  参考文献:Methods In Molecular Biology (New York 日期:2019 卷标:2019 页码:109-121]
  
  102121-55-1 = 92050-16-3
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  标题:Retinoid Compounds With Retinoic Acid Receptor Agonist Activity
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  102121-55-1 = 92050-16-3
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  102121-55-1 = 92050-16-3
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  标题:Aza-Retinoids As Novel Retinoid X Receptor-Specific Agonists
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  102121-55-1 = 92050-16-3
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  102121-55-1 = 92050-16-3
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  102121-55-1 = 92050-16-3
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  139162-43-9 = 92050-16-3
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  参考文献:China]
  
  6683-46-1 = 92050-16-3
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  139162-43-9 = 92050-16-3
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  102121-55-1 = 92050-16-3
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海关参考信息

• 2902600000-乙苯
  2902700000-异丙基苯
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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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• ➥ REACH监管