CAS: 822-39-9; Ethylene Chlorophosphite

上下游产品

ethylene glycol 2-methyl-[1,3,2]dioxarsolane pyridine diethyl ether -aethylenesterPhosphonigsaeure-2-chloraethylester-aethylenester 2-Piperidino-4,5-dihydro-1,3,2-dioxaphosphole 2-(2'-hydroxyethoxy)-1,3,2-dioxaphospholane methoxy-2 dioxaphospholane-1,3,2

📜乙二醇置于三乙胺,三氯化磷体系中,用 四氢呋喃 作为反应溶剂,化学反应 12.0H,反应生成 2-氯-1,3,2-二氧磷杂环戊烷
参考文献:具有两个正交保护基的多功能聚(磷酸酯)†
标题:具有两个正交保护基的多功能聚(磷酸酯)†
摘要:开发了一种新型的环状磷酸酯单体2-(2-(苄氧基)乙氧基)-1,3,2-二氧杂磷杂环戊烷-2-氧化物(bneep),可通过阴离子环-反应生成含受保护侧链羟基的聚磷酸酯.开放聚合.通过温和的催化氢化释放羟基,使聚合物主链保持完整.另外,通过bneep与乙基乙基磷酸酯(eep)的共聚来改变侧链羟基的数目.此外,Bneep与乙缩醛保护的环状磷酸酯2-(2,2-二甲基-1,3-二氧戊环-4-基-甲氧基)-2-Oxo-1,3,2-二氧杂磷烷(gep)的共聚物为为了分别通过酸性水解或催化氢化来建立缩醛或苄基保护基的选择性脱保护基而制备.在报道的条件下未检测到聚酯主链的降解.该新型单体允许调节聚(磷酸酯)的化学和物理性质,并获得各种侧链官能度.
DOI:10.1039/c5Ra07167D

专利信息

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:WO-9714703-A1
优先权日:1995-10-16
标 题:Synthesis of polymerisable phosphodiesters
发明人：DRIVER MICHAEL JOHN; RUSSEL JEREMY COLIN; BROWNE JUDITH ELIZABETH; SAMMES PETER G
权利人:BIOCOMPATIBLES LTD; DRIVER MICHAEL JOHN; RUSSEL JEREMY COLIN; BROWNE JUDITH ELIZABETH; SAMMES PETER G
摘要:A mono- or di-functional phosphoramidite phosphitylating agent is used to phosphitylate an ethylenically unsaturated alcohol. The product may be oxidised to form the corresponding phosphate ester which may be reacted in further steps to form phosphoryl choline derivatives. The process is of value in the synthesis of 2-(Methacryloyloxyethyl)-2'-(trimethylammoniumethyl)phosphate, inner salt. It has the advantage over prior art processes in that the starting materials and intermediates are more stable and consequently easier to handle.

专利号:US-2017267706-A1
优先权日:2014-08-19
标 题:Method for the synthesis of heterocyclic hydrogen phosphine oxide
发明人：BRUYNEEL FREDERIC; NOTTE PATRICK PIERRE
权利人:STRAITMARK HOLDING AG
摘要:A method for the synthesis of a heterocyclic hydrogen phosphine oxide, having the general formula: n n n n n n n n n n wherein:n nR is a aliphatic or aromatic divalent group optionally including one or more heteroatoms and optionally having one or more substituents andn nX and Y are independently selected from —O—, —C(O)O— and —NR′—n nwherein R′ is a monovalent group optionally having one or more heteroatoms including the steps of:n na) forming a reaction mixture by mixing a compound having the general formula HX—R—YH and tetraphosphorus hexaoxide; andn nb) recovering the resulting compound comprising the heterocyclic hydrogen phosphine oxide.

专利号:US-5847185-A
优先权日:1997-11-21
标题 :C-15 phosphonate reagent compositions and methods of synthesizing the same
发明人：BABLER JAMES H
权利人:LOYOLA UNIVERSITY OF CHICAGE
摘要:Allenic phosphonate reagent compositions are described which have the formula: ##STR1## wherein R and R'=C 1 -C 4 alkyl groups, or R, R'=(CH 2 ) n (n=2 or 3) or CH 2 C(CH 3 ) 2 CH 2 !. n Also described are methods for forming such allenic phosphonates from ethynyl-β-ionol, and for converting these allenic compounds to allylic phosphonate compounds which can be used in the synthesis of a variety of biologically-active materials.

专利号:WO-9816535-A1
优先权日:1996-10-16
标 题 :Synthesis of phosphorus compounds
发明人：DRIVER MICHAEL JOHN; WILMAN LAURA AINSLEY; JACKSON DEBORAH JANE
权利人:BIOCOMPATIBLES LTD; DRIVER MICHAEL JOHN; WILMAN LAURA AINSLEY; JACKSON DEBORAH JANE
摘要:A new phosphoramidite reagent has general formula (I) in which R12 is a C¿2-4? -alkylene, -alkenylene or -alkynylene group, which is unsubstituted or substituted by halogen atoms, hadroxyl, amine, alkyl or aryl groups or which is part of a fused ring, m is 2 or 3, the groups R?1¿ are the same or different and each represents branched or straight alkyl groups (including cycloalkyl) or, two of the groups or all three of the groups R1, together with the nitrogen atom to which they are attached, form a heterocyclic group optionally containing other heteroatoms and being saturated or unsaturated, provided that when m is 2 one of the groups R1 is joined to the nitrogen atom by a carbon-nitrogen double bond, and XÏ… is a counterion. The compound is preferably used to phosphitilate an alcohol, especially an ethylenically unsaturated polymerisable alcohol. The phosphorous triester is preferably oxidised and ring opened, preferably by a simultaneous amination reaction.