5-氯-2-溴-3-硝基吡啶置于盐酸,铁粉,溶剂黄146体系中,化学反应生成 2,5-二氯吡啶-3-胺 参考文献:Berrie Et Al.,Journal Of The Chemical Society,1952,P. 2042,2044 标题:Berrie Et Al.,Journal Of The Chemical Society,1952,P. 2042,2044
专利号:US-8937072-B2 优先权日:2011-06-17 标题:Substituted cyanoaniline compounds, preparation and use thereof 发明人:LIU CHANGLING; HUANG GUANG; LAN JIE; HAO SHULIN; LI ZHINIAN; LI HUICHAO; GUAN AIYING; JIANG AIRU; XU YING 权利人:LIU CHANGLING; HUANG GUANG; LAN JIE; HAO SHULIN; LI ZHINIAN; LI HUICHAO; GUAN AIYING; JIANG AIRU; XU YING; SINOCHEM CORP; SHENYANG RES INST CHEMICAL IND 摘要:Disclosed is a substituted cyanoaniline compound or a salt thereof, wherein the compound has a structure represented by General Formula I. The compound of General Formula I has broad-spectrum fungicidal activity in the field of agriculture and effectively prevents against a variety of pathogens such as cucumber downy mildew, wheat powdery mildew, maize rust disease, rice blast and cucumber gray mold. In particular, even at a low dose, the compound effectively prevents and treats rice blast, cucumber gray mold, maize rust disease and cucumber downy mildew. Moreover, the raw materials for preparing the compounds are widely available and the synthesis method therefor is simple and convenient.
参考文献:10.1021/jm9016366 摘要:Haydon DJ, Bennett JM, Brown D, Collins I, Galbraith G, Lancett P, Macdonald R, Stokes NR, Chauhan PK, Sutariya JK, Nayal N, Srivastava A, Beanland J, Hall R, Henstock V, Noula C, Rockley C, Czaplewski L. Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties. J Med Chem. 2010 May 27;53(10):3927–36.