CAS: 766-96-1; 1-Bromo-4-Ethynylbenzene

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CAS号16116-78-2 (4-溴苯基乙炔基)三甲基硅烷 | CAS号90965-06-3 (1-重氮基-2-氧代丙基)膦酸二甲酯 | CAS号1122-91-4 对溴苯甲醛 | CAS号99-90-1 4-溴苯乙酮 | CAS号76347-62-1 4-(4-溴苯基)-2-甲基-... | CAS号589-87-7 对溴碘苯 | CAS号1066-54-2 三甲基硅基乙炔 | CAS号112595-55-8 2,3-DIBROMO-2-(... | CAS号115665-77-5 1‐bromo‐4‐[(E)‐... | CAS号34658-66-7 2-(4-溴苯基)咪唑并[1,... | CAS号13041-70-8 反-4-溴二苯乙烯 | CAS号4714-24-3 4-溴均二苯乙烯 | CAS号41841-16-1 4-溴苯乙酸甲酯 | CAS号41876-70-4 4'-二乙基氨基苯乙炔 | CAS号948292-48-6 3-(4-溴苯基)-1H-吡唑... | CAS号190649-11-7 1-bromo-4-hex-1... | CAS号189099-57-8 1-bromo-4-[2-(4... | CAS号99-90-1 4-溴苯乙酮 | CAS号342808-62-2 1-(4-bromopheny...

(2Rs,3Sr)-2,3-Dibromo-3-(4-Bromophenyl)Propanoic Acid置于potassium Carbonate体系中,用 二甲基亚砜 作为反应溶剂,化学反应 12.0H,以94%的收率获得产物(4-溴苯基)乙炔
参考文献:使用k2Co3 / Dmso系统方便地从抗3-芳基-2,3-二溴丙酸合成末端炔烃
标题:使用k2Co3 / Dmso系统方便地从抗3-芳基-2,3-二溴丙酸合成末端炔烃
摘要:在dmso和k 2 Co 3的存在下,开发了一种方便,有效且普遍适用的方法,用于从抗3-芳基-2,3-二溴丙酸合成末端炔烃.
DOI:10.1002/cjoc.201180402

专利信息

专利号:US-10829792-B2
优先权日:2017-03-21
标 题 :Biocatalytic synthesis of strained carbocycles
发明人：CHEN KAI; HUANG XIONGYI; KAN S B JENNIFER
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.

专利号:US-8835658-B2
优先权日:2012-12-28
标 题:Asymmetric synthesis of norcantharidin analougus by alkynylation of oxabenzonorbornadienes and their anticancer activities
发明人：CHAN ALBERT SUN-CHI; FAN BAOMIN; WANG JUN; LIN CHENGYUAN; HUANG CHAO; YANG QINGJING; XU JIANBIN; BIAN ZHAOXIANG; LU AIPING; HU JUN
权利人:UNIV HONG KONG BAPTIST; UNIV YUNNAN NATIONALITIES
摘要:The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-11033889-B2
优先权日:2018-10-23
标 题:Palladium acyclic diaminocarbene complexes as precatalysts for Hiyama coupling and the tandem one-pot fluoride free Hiyama coupling/cyclization for the synthesis of biologically relevant
发明人：SINGH CHANDAN; GHOSH PRASENJIT
权利人:INDIAN INST TECHNOLOGY BOMBAY
摘要:The present invention provides Acyclic diaminocarbene complex of formula (I):Wherein,M is palladium;X is monoanionic ligand selected from Cl, Br or I;Where R1 is different from R2;R1 is selected from the group consisting of alkyl or aryl, each of which have 4 to 20 carbon atoms, and may optionally contain one or more heteroatoms;R2 is selected from the group consisting of alkyl, or aryl each of which have 4 to 20 carbon atoms, and may optionally contain one or more heteroatoms. The said palladium diamino carbine complex of the present invention are particularly useful as catalyst from Hiyama cross-coupling reaction.

专利号:US-7473797-B2
优先权日:2004-04-27
标 题 :Methods of 1,3-enyne preparation using copper (I) catalysts
发明人：VENKATARAMAN DHANDAPANI; BATES CRAIG G; SAEJUENG PRANORM
权利人:UNIV MASSACHUSETTS
摘要:A copper(I) bi-dentate ligand complex-catalyzed procedure for synthesis of 1,3-enynes. The methods and/or systems of this invention afford a variety of enynes, tolerate a variety of sensitive functional groups, and can be employed without resort to expensive palladium reagents.

专利号:US-2022048879-A1
优先权日:2020-08-13
标 题:Synthesis of small molecules inspired by Phomoxanthone A
发明人：ALI RAMEEZ; MATTSON ANITA
权利人:WORCESTER POLYTECH INST
摘要:Methods, compositions, and kits are provided for synthesizing bioactive chromane, the method including: constructing a tertiary ether stereocenter enantioselectively by catalyzed alkynylation of a substituted chromenone to obtain a chromanone; reducing alkyne and ketone in the chromanone to obtain a chroman; and converting ester to methyl group thereby obtaining chromane.